ID G3MWQ9_BOVIN Unreviewed; 693 AA.
AC G3MWQ9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN Name=LOC785907 {ECO:0000313|Ensembl:ENSBTAP00000053962.2};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000053962.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000053962.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053962.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000053962.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053962.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|RuleBase:RU003732}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3MWQ9; -.
DR PaxDb; 9913-ENSBTAP00000053962; -.
DR Ensembl; ENSBTAT00000063664.2; ENSBTAP00000053962.2; ENSBTAG00000030505.3.
DR VEuPathDB; HostDB:ENSBTAG00000030505; -.
DR eggNOG; KOG3659; Eukaryota.
DR GeneTree; ENSGT00940000163157; -.
DR HOGENOM; CLU_006855_7_2_1; -.
DR InParanoid; G3MWQ9; -.
DR OMA; PLMYMEM; -.
DR TreeFam; TF352709; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000030505; Expressed in spermatocyte and 16 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR PANTHER; PTHR11616:SF233; TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Symport {ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 50..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..693
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 693 AA; 78510 MW; 8597A259837937CE CRC64;
VMESLEEISE EESPKERHTS STPSWKLTAK EILATKTQNY FAQTKRAENI LIQIAFSIGL
SSIWRFPYLC HLNGGGSFIL VYFFMLLFFG VPLMYMEMIM GKCLRVDNIR VWKQLVPWLG
GIGYASILVC ILVSLYNSII ITWSLSYLSN SFRYPLPWDK CPLVRNINVT DLSCLQTVTH
QYFWYHTTLN ASNHIEEEVE TLVLNLTLGI FTVWFLLFLI MMVGLKISMQ TLIFSVFLPY
IILLCFLIRC LFLEGATTSL RRMVTTEFSA WASLDLWRQA GGHVLYSLGL GMGTIILFSY
KSGGYQQQKN SYCHPFLKKC IYCISFMTLM QLIDEGVLPQ NAKPPKDILL LPTLDYIKWI
NSLPGHLRQK VIHLSPSCSI KVQKEMFMEG PGLALAAFSQ VVSLFPGSSF WAILFFMALL
IIGLSNLMRL LEGIVFPLQN SISIFRNYPR ILSAIVCLGG FLGSLVFTSR AGSYIMYLFD
DLLVPLTLII TVVFQNMALA WIYGAGRFRE EMFSEMGRPL WPFSSFLWCY VTLPGLLALL
TICLMQLYQG THLYYTAWNT SGWWSLQDYV APDPFGKLMS KKTPMLSSMS SQRPKHHSVK
SPERTSNAST RGLSMSLLRS LKPESGCLSQ DSEKYEGSSW FSLPLVTSLS SSLTIRSASL
RVSRQVSPAS INTDSSYKGG ETKEESPKET SVH
//
