ID G3MY82_BOVIN Unreviewed; 580 AA.
AC G3MY82;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Mucolipin TRP cation channel 1 {ECO:0000313|Ensembl:ENSBTAP00000054510.1};
GN Name=MCOLN1 {ECO:0000313|Ensembl:ENSBTAP00000054510.1,
GN ECO:0000313|VGNC:VGNC:31318};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000054510.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000054510.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000054510.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000054510.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000054510.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3MY82; -.
DR SMR; G3MY82; -.
DR STRING; 9913.ENSBTAP00000054510; -.
DR PaxDb; 9913-ENSBTAP00000054510; -.
DR Ensembl; ENSBTAT00000065500.2; ENSBTAP00000054510.1; ENSBTAG00000005592.6.
DR VEuPathDB; HostDB:ENSBTAG00000005592; -.
DR VGNC; VGNC:31318; MCOLN1.
DR eggNOG; KOG3733; Eukaryota.
DR GeneTree; ENSGT00950000183036; -.
DR HOGENOM; CLU_020945_1_1_1; -.
DR InParanoid; G3MY82; -.
DR OMA; CQQYYRR; -.
DR TreeFam; TF317783; -.
DR Reactome; R-BTA-3295583; TRP channels.
DR Reactome; R-BTA-917977; Transferrin endocytosis and recycling.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000005592; Expressed in cortex of kidney and 109 other cell types or tissues.
DR ExpressionAtlas; G3MY82; baseline and differential.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0097682; F:intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity; IEA:Ensembl.
DR GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IBA:GO_Central.
DR GO; GO:0097352; P:autophagosome maturation; IEA:Ensembl.
DR GO; GO:1901660; P:calcium ion export; IEA:Ensembl.
DR GO; GO:0071277; P:cellular response to calcium ion; IEA:Ensembl.
DR GO; GO:0071467; P:cellular response to pH; IEA:Ensembl.
DR GO; GO:0090382; P:phagosome maturation; IEA:Ensembl.
DR GO; GO:1905673; P:positive regulation of lysosome organization; IEA:Ensembl.
DR GO; GO:0051289; P:protein homotetramerization; IEA:Ensembl.
DR CDD; cd21070; ELD_TRPML1; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR047316; ML1_ELD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF6; MUCOLIPIN-1; 1.
DR Pfam; PF21381; MCLN_ECD; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 299..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 91..285
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 385..524
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 65074 MW; 378CC4EC17966C5E CRC64;
MAVPVGPRGS ETERLLTPSP GYGTQTGASP APSTPPEEED LRRRLKYFFM SPCDKFRAKG
RKPFKLMLQV VKILVVTVQL ILFGLSNQLA VTFREENTIA FRHLFLLGYT DGADDTFAAY
TRQQLYQAIF YAVDQYLTLP DVSLGRYAYV RGGGGPWANG SALALCQCYY HRGHVDPAND
TFDIDPMVVT DCIRVDPPER PPVPPSDDFS LSDGSASYRN LTLKFHKLIN VTIHFQLKTI
NLQSLINNEI PDCYTFSILI TFDNKAHSGR VPISLETQAH IQECKHPSVF GHGDNSFRLL
FDVVVILTCA FSFLLCARSL LRGFLLQNEF VRFMWRRRGR VISLWERLEF VNGWYILLVT
SDMLTISGTI MKIGIEAKNL ASYDVCSILL GTSTLLVWVG VIRYLTFFHK YNILIATLRV
ALPSVMRFCC CVAVIYLGYC FCGWIVLGPY HVKFRSLSMV SECLFSLING DDMFVTFAAM
QAQQSRSSLV WLFSQLYLYS FISLFIYMVL SLFIALITGA YDTIKHPGGA GAEVSELQAY
IAQCQDSPTS GKFRRGSGSA CSLLCCCGRD ASEEHSLLVN
//
