ID G3MYP3_BOVIN Unreviewed; 284 AA.
AC G3MYP3; A0A024FBV6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Programmed cell death 1 ligand 2 {ECO:0000313|Ensembl:ENSBTAP00000054680.2};
DE SubName: Full=Programmed death ligand 2 {ECO:0000313|EMBL:BAO74173.1};
GN Name=PDCD1LG2 {ECO:0000313|Ensembl:ENSBTAP00000054680.2,
GN ECO:0000313|VGNC:VGNC:56980};
GN Synonyms=PD-L2 {ECO:0000313|EMBL:BAO74173.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000054680.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|EMBL:BAO74173.1}
RP NUCLEOTIDE SEQUENCE.
RA Nishimri A., Konnai S., Murata S., Ohashi K.;
RT "Bovine PD-L2-Ig enhances cell proliferation and IFN-gamma production.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000054680.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000054680.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000054680.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000054680.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AB898679; BAO74173.1; -; mRNA.
DR RefSeq; NP_001278965.1; NM_001292036.1.
DR Ensembl; ENSBTAT00000065523.2; ENSBTAP00000054680.2; ENSBTAG00000033316.4.
DR GeneID; 539392; -.
DR KEGG; bta:539392; -.
DR CTD; 80380; -.
DR VEuPathDB; HostDB:ENSBTAG00000033316; -.
DR VGNC; VGNC:56980; PDCD1LG2.
DR GeneTree; ENSGT00940000157590; -.
DR HOGENOM; CLU_147071_0_0_1; -.
DR Proteomes; UP000009136; Chromosome 8.
DR Bgee; ENSBTAG00000033316; Expressed in mesenteric lymph node and 80 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd20983; IgV_PD-L2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR25466:SF1; PROGRAMMED CELL DEATH 1 LIGAND 2; 1.
DR PANTHER; PTHR25466; T-LYMPHOCYTE ACTIVATION ANTIGEN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..284
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041117360"
FT TRANSMEM 233..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 146..219
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 284 AA; 31770 MW; C6B8FB8FC3158691 CRC64;
MMRLPQSDPV QSMFLLLILS LGLQLQQTVA LFTVTIPKEM YMVDYGSNVT LECDFDTGGP
VELGILKASL QKVENDTVLL SERATLLEEQ LPLGKALFLI PRIQLKDAGQ YRCLIIYGIA
WDYKYLTLKV KASYKKINTR HLKVPGTDEV ELTCQAEGYP LAEVSWPNIS IPTNTSHTKT
SEGLYQVTSV LRLKPHPGRN FSCVFWNANV KELTSATIVQ GPLEDPKIPS SSLLHVFILS
LIVAPIFIAT VVALRKRLCQ KLYSGEDSTK RSATMVRREV DRAI
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