GenomeNet

Database: UniProt
Entry: G3N0E5_BOVIN
LinkDB: G3N0E5_BOVIN
Original site: G3N0E5_BOVIN 
ID   G3N0E5_BOVIN            Unreviewed;      4469 AA.
AC   G3N0E5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   16-JAN-2019, entry version 54.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSBTAP00000055305};
GN   Name=RYR3 {ECO:0000313|VGNC:VGNC:34235};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000055305, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000055305, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055305,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000055305}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055305};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; DAAA02028389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02028390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PRIDE; G3N0E5; -.
DR   Ensembl; ENSBTAT00000064357; ENSBTAP00000055305; ENSBTAG00000025642.
DR   VGNC; VGNC:34235; RYR3.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000155507; -.
DR   OrthoDB; 5161at2759; -.
DR   Reactome; R-BTA-2672351; Stimuli-sensing channels.
DR   Reactome; R-BTA-5578775; Ion homeostasis.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000025642; Expressed in 10 organ(s), highest expression level in testis.
DR   ExpressionAtlas; G3N0E5; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4215   4243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4447   4467       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        8     63       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       70    115       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      123    177       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      183    241       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      251    308       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      500    711       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      927   1123       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1260   1482       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3949   3984       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     2981   3001       {ECO:0000256|SAM:Coils}.
FT   COILED     3248   3268       {ECO:0000256|SAM:Coils}.
FT   COILED     3428   3448       {ECO:0000256|SAM:Coils}.
FT   COILED     4369   4389       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4469 AA;  505082 MW;  FBFEE5AC100DDB2D CRC64;
     QAAQGGGHRT LLYGHAILLR HSFSGMYLTC LTTSRSQTDK LAFDVGLREH ATGEACWWTI
     HPASKQRSEG EKVRIGDDLI LVSVSSERYL HLSISNGNIQ VDASFMQTLW NVHPTCSGSS
     IEEGYLLGGH VVRLFHGHDE CLTIPSTDQN DSQHRRIYYE AGGAGTRARS LWRVEPLRIS
     WSGSNIRWGQ AFRLRHLTTG HYLALTEDQG LILQDRGKSD TKSTAFSFRA SKEIKEKLDS
     SHKRDIEGMG VPEIKYGDSV CFVQHIASGL WVTYKAQDAK TSRLGPLKRK VILHQEGHMD
     DGLTLQRCQR EESQAARIIR NTTALFSQFV RYGVDSFIGN SRTAAPVTLP IEEVLQTLHD
     LIAYFQPPEE GMQHEGKQNK LRSLKNRQNL FKEEGMLALV LNCIDRLNIY NSIAHFAGIA
     REESGMAWKE ILNLLYKLLA ALIRGNRNNC AQFSNNLDWL ISKLDRLESS SGILEVLHCI
     LIESPEALNL IAEGHIKSII SLLDKHGRNH KVLDVLCSLC LCDGVAVRAN QNLICDNLLP
     RRNLLLQTRL INDVTSIRPN IFLGVAEGSA QYKKWYFELI IDQVDPFLTA EPTHLRVGWA
     SSSGYAPYPG GGEGWGGNGV GDDLYSYGFD GLHLWSGRIP RAVASINQHL LKSDDVVSCC
     LDLGAPSISF RINGQPVQGM FENFNTDGLF FPVVSFSAGV KVRFLLGGRH GEFKFLPPSG
     YAPCYEALLP KEKMRLEPVK EYKRDAEGIR DLLGTTQFLS QASFIPCPID TSQVVLPPHL
     EKIRDRLAEN IHELWGMNKI ELGWTFGKIR DDNKRQHPCL VEFSKLPETE KNYNLQMSTE
     TLKTLLALGC HIAHVNPAAE DDLKKVKLPK NYMMSNGYKP APLDLSDVKL LPPQEVLVDK
     LAENAHNVWA KDRIKQGWTY GIQQDLKNKR NPRLVPYSLL DERTKKSNRD SLREAVRTFV
     GYGYNIEPSD QELADPAVEK VSIDKIRFFR VERSYAVRSG KWYFEFEVVT GGDMRVGWAR
     PGCRPDIELG ADDQAFVFEG SRGQRWHQGS GYFGRTWQPG DVVGCMINLD DASMIFTLNG
     ELLITNKGSE LAFADYEIDN GFVPICSLGL SQIGRMNLGM DASTFKFYTM CGLQEGFEPF
     AVNMNRDVAM WFSKRLPTFV NVPKDHPQIE VVRIDGTMDT PPCLKVTHKT FGTQNSSATM
     IYCRLSMPVE CHSSFSHSPC MDSDAFQKRA EELKHGLSSP QETDNISMAS LKWGKEKQLK
     GTPVEGERGA EMHVTPSIKL PCNPVIIANQ KIGDNNKCAK AQQKAGKQGS QVLASALPLV
     QRAGHTPVQS LGSLTPSVVS PQQCYYAIRI FAGQDPSCVW VGWVTPDYHL YSEKFDLNKN
     CTVTVTLGDE RGRVHESVKR SNCYMVWGGD IVATSQRASR SNVDLEIGCL VDLAMGMLSF
     SANGRELGTC YQVEPNTKVF PAVFLQPTST SLFQFELGKL KNAMPLSAAI FKSEEKNPVP
     QCPPRLDVQT IQPVLWSRMP SSFLKVETER VSERHGWVVQ CLEPLQMMAL HIPEENRCVD
     ILELCEQEDL MRFHYHTLRL YSALCALGNS RVAYALCSHV DLSQLFYAID NKYLPGLLRS
     GFYDLLISIH LASAKERKLM MKNEYIIPIT STTRKIRLYP DESKRHGLPG VGPRTCLKPG
     FRFSTPCFIT TNEEHQKQSP EIPLELLKTK ALGMLTEAVQ CSGAHIRDPV GGSVEFQFVP
     VLKLIGTLLI MGVFDDDDVR QILLLIDPSV FGEHSGETEE GAEKEEVTQV EEKAVEAGEK
     ASREAPIKGL LQTRLPESVK LQMCELLSYL CDCELQHRVE AIVAFGDIYV SKLQENQKFR
     YNELMQALNM SAALTARKTR EFRSPPQEQI NMLLNFQLGE NCPCPEEIRE ELYDFHEDLL
     LHCGVPLEEE EEEEEDSSWT GKFCALVQRI KGPPKPEKEQ PTEEEERCPT TLKELISQTM
     IRWAQEDQIQ DAELVRMMFN LLRRQYDSIG ELLQALRKTY TISQASVSDT ISLLAALGQI
     RCLLSVRMGK EEELLMINGL GDIMNNKVFY QHPNLMRVLG MHETVMEVMV NVLGAEKLQI
     AFPKMVASCC RFLCYFCRIS RQNQKAMFEH LSYLLENSSV GLASPSMRGS TPLDVAASSV
     MDNNELALGL EEPDLEKVVT YLAGCGLQSC PMLLAKGYPD VGWNPIEGER YLSFLRFAVF
     VNSESVEENA SVVVKLLIRR PECFGPALRG EGGNGLLAAM QGAIKISENP ALDLPSQGYK
     REVHHFCSTE DDDDEEEIVH MGNAIMSFYS ALIDLLGRCA PEMHLIQTGK GEAIRIRSIL
     RSLVPTEDLV GIISIPLKLP SLNKDGSVSE PDMAANFCPD HKAPMVLFLD RVYGIKDQTF
     LLHLLEVGFL PDLRASASLD TVSLSTTEAA LALNRYICSA VLPLLTRCAP LFAGTEHYTS
     LIDSTLQTIY RLSKGRSLTK AQRDTIEECL LAICNHLRPS MLQQLLRRLV FDVPQLNEYC
     KMPLKLLTNH YEQCWKYYCL PSGWGSYGLA VEEELHLTEK LFWGIFDSLS HKRYDPDLFR
     MALPCLSAIA GALPPDYLDT RISATLEKQV SVDADGNFDP KPINTVNFSL PEKLEYIVTK
     YAEHSHDRWA CDKSQNGWKY GISLDENVKT HPLIRPFKTL TEKEKDIYRW PARESLKTML
     AVGWTVERTK EGEALVQQRE NEKLRSVSQA SQVRPSRPKG NSYSPAPLDL SNVVLSRELQ
     GMVEVVAENY HNIWAKKKKL ELESKGGGSH PLLVPYDTLT AKEKFRDREK AQDLFKFLQV
     NGIVVSRGMK DMELDASSME KRFAYKFLKK VLKYVDSAQE FIAHLEAIVS SGKNEKSPHD
     QEIKFFAKVL LPLVDQYFIN HRLYFLSSPL KPLSSSGYAS HKEKEMVASL FCKLAALVRH
     RISLFGSDST TMVSCLHILA QTLDTRTVMK SGSELVKAGL RAFFENAAED LEKTLENLKL
     GKFTHSRTQI KGVSQNINYT TVALLPILTS IFEHVAQHQF GVDLLLGDVQ LSCYHILCSL
     YSLGTGKNIY VERQRPALGE CLASLAAAIP VAFLEPTLNR YNPLSVFNTK TPRERSILGM
     PDTVEEMCPD IPQLEGLMKE INDLAESGAR YTEMPHVIEV ILPMLCNYLS YWWERGPEHL
     PPSAGPWCTK VTSEHLSVIL GNILKIINNN LGIDEASWMK RIADTVYAQP IISKARPDLL
     RSHFIPTLEK LKKKAIKTVQ EEEQLRADSK GDTQEAELLI LDEFAVLCRD LYAFYPMLIR
     YVDNNRSNWL KSPDADSDQL FRMVAEIFIL WCKSHNFKRE EQNFVIQNEI NNLAFLTGDS
     KSKMSKAMQV KSGGQDQERK KTKRRGDFYS IQTSLIVAAL KKMLPIGLNM CTPGDQELIS
     LAKSRYSYKD TDEEVKEHLR NNLHLQEKSD DPAVKWQLNL YKDVLKSEEP SNPEKTVERV
     QRISAAVFHL EQVEQPLRSK KAVWHKLLSK QRKRAVVACF RMAPLYNLPR HRSINLFLHG
     YQRFWIETEE YSFEEKLVQD LAKSPKVEEE EEEEVEKQPD PLHQIILHFS RNALTERSKL
     EDDPLYTSYA SMMAKSCQSG EDEDEDEDKE KTFEEKEMEK QKTLYQQARL HERGAAEMVL
     QMISASKGEM SPMVVETLKL GIAILNGGNA GVQQKMLDYL KEKKDAGFFQ SLSGLMQSCR
     SVLDLNAFER QNKAEGLGMV TEEGTLIVRE RGEKVLQNDE FTRDLFRFLQ LLCEGHNSDF
     QNFLRTQMGN TTTVNVIIST VDYLLRLQES ISDFYWYYSG KDIIDESGQH NFSKALAVTK
     QIFNSLTEYI QGPCIGNQQS LAHSRLWDAV VGFLHVFANM QMKLSQDSSQ IELLKELLDL
     LQDMVVMLLS LLEGNVVNGT IGKQMVDTLV ESSTNVEMIL KFFDMFLKLK DLTSSDTFKE
     YDPDGKGIIS KKEFQKAMEG QKQYTQSEID FLLSCAEADE NDMFNYIDFV DRFHEPAKDI
     GFNVAVLLTN LSEHMPNDSR LKCLLDPAES VLNYFEPYLG RIEIMGGAKK IERVYFEISE
     SSRTQWEKPQ VKESKRQFIF DVVNEGGEQE KMELFVNFCE DTIFEMQLAS QISESDSADR
     PDEEEEEGGD SSYVLEVEGE EEEEEKSFEC ASAFAMACGS VKRNVANFLK RATLKNLRKQ
     YRKVKKMTFK ELVKVFFSFF WTLFMGLFHL LFTIVGGIIQ VLWSTVFGGG LIEGAKNIRV
     TKILGDMPDP TQFGIHDDAM EAERAEVPEP GIATELVHFV KGQKGDADIM SDLFGLHPKK
     EGGLKHGPEV GLGDLSEIIG KDETPTLEST VRKKRKAQVS TQAAEMKAAH EAERKIESEK
     ADMEDGEKED TAKEEEQAEA LWADVTKRKK RRCGQKVEKP EAFMANFFKG LEIYQTKLLH
     YLARNFYNLR FLALFVAFAI NFILLFYKV
//
DBGET integrated database retrieval system