ID G3N0P4_BOVIN Unreviewed; 287 AA.
AC G3N0P4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Parkin RBR E3 ubiquitin protein ligase {ECO:0000313|Ensembl:ENSBTAP00000055410.1};
GN Name=PRKN {ECO:0000313|Ensembl:ENSBTAP00000055410.1,
GN ECO:0000313|VGNC:VGNC:33342};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000055410.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000055410.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055410.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000055410.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055410.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3N0P4; -.
DR SMR; G3N0P4; -.
DR Ensembl; ENSBTAT00000062978.2; ENSBTAP00000055410.1; ENSBTAG00000018996.6.
DR VEuPathDB; HostDB:ENSBTAG00000018996; -.
DR VGNC; VGNC:33342; PRKN.
DR GeneTree; ENSGT00390000011034; -.
DR HOGENOM; CLU_050804_1_0_1; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000009136; Chromosome 9.
DR Bgee; ENSBTAG00000018996; Expressed in oocyte and 107 other cell types or tissues.
DR ExpressionAtlas; G3N0P4; baseline.
DR GO; GO:0005829; C:cytosol; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd16627; RING-HC_RBR_parkin; 1.
DR CDD; cd21382; RING0_parkin; 1.
DR CDD; cd01798; Ubl_parkin; 1.
DR InterPro; IPR003977; Parkin.
DR InterPro; IPR041565; Parkin_Znf-RING.
DR InterPro; IPR047535; RING-HC_RBR_parkin.
DR InterPro; IPR015496; Ubiquilin.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR041170; Znf-RING_14.
DR PANTHER; PTHR10677; UBIQUILIN; 1.
DR PANTHER; PTHR10677:SF40; UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR Pfam; PF17976; zf-RING_12; 1.
DR Pfam; PF17978; zf-RING_14; 1.
DR PRINTS; PR01475; PARKIN.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 1..76
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT REGION 72..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 287 AA; 31864 MW; 6DED0E84A7FBDFD4 CRC64;
MKVFVRFNSN HGFPVEVDSD TSIFQLKEVV ARRQGVPADQ LCVIFAGKEL RNDWTVQSCD
LDQQSIVHIV LRPRRKGPEG HSPRPAWGRS DREPESLTRV DLSSSMLPAD SVGLAVILQD
GEESGASSAR RPAGRPTYNS FYVYCKGPCQ GVQPGKLRVR CSTCQQATLT LAQGPSCWED
VLIPNRMSGE CQSPNCPGTR AEFFFKCGAH PTSDKETSVA LNLITTNSRD ISCITCTDIR
SPVLVFQCTH RHVICLDCFH LYCVTRLNDR QFVHDPQLGY SLPCVDS
//
