ID G3N116_BOVIN Unreviewed; 299 AA.
AC G3N116; F1MIZ4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=GRAM domain containing 2A {ECO:0000313|Ensembl:ENSBTAP00000055538.2};
GN Name=GRAMD2A {ECO:0000313|Ensembl:ENSBTAP00000055538.2,
GN ECO:0000313|VGNC:VGNC:29625};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000055538.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000055538.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055538.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000055538.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055538.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_010807328.1; XM_010809026.2.
DR RefSeq; XP_010808319.1; XM_010810017.2.
DR RefSeq; XP_015320465.1; XM_015464979.1.
DR RefSeq; XP_015328548.1; XM_015473062.1.
DR STRING; 9913.ENSBTAP00000044611; -.
DR PaxDb; 9913-ENSBTAP00000044611; -.
DR Ensembl; ENSBTAT00000047402.4; ENSBTAP00000044611.4; ENSBTAG00000046391.2.
DR Ensembl; ENSBTAT00000064241.2; ENSBTAP00000055538.2; ENSBTAG00000046391.2.
DR GeneID; 100300494; -.
DR CTD; 196996; -.
DR VEuPathDB; HostDB:ENSBTAG00000046391; -.
DR VGNC; VGNC:29625; GRAMD2A.
DR eggNOG; KOG1032; Eukaryota.
DR GeneTree; ENSGT00940000159572; -.
DR HOGENOM; CLU_050698_0_1_1; -.
DR OMA; GRWAWPM; -.
DR OrthoDB; 45896at2759; -.
DR TreeFam; TF327695; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000046391; Expressed in caput epididymis and 83 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central.
DR GO; GO:0044232; C:organelle membrane contact site; IBA:GO_Central.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IBA:GO_Central.
DR GO; GO:0061817; P:endoplasmic reticulum-plasma membrane tethering; IBA:GO_Central.
DR GO; GO:2001256; P:regulation of store-operated calcium entry; IBA:GO_Central.
DR CDD; cd13220; PH-GRAM_GRAMDC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR042624; RAMD2A.
DR PANTHER; PTHR46973; GRAM DOMAIN-CONTAINING PROTEIN 2A; 1.
DR PANTHER; PTHR46973:SF1; GRAM DOMAIN-CONTAINING PROTEIN 2A; 1.
DR Pfam; PF02893; GRAM; 1.
DR SMART; SM00568; GRAM; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..119
FT /note="GRAM"
FT /evidence="ECO:0000259|SMART:SM00568"
SQ SEQUENCE 299 AA; 34148 MW; 59595A9FD8F61391 CRC64;
MHGKTASLKK STEKLGGVQR AQDTSLYWPE GLKGEDVKKC RQEGMLLSKY NQQYHKLFKD
IPLEEVVLKV CSCALQRDLL LQGRLYISSN WLCFHASLFG KDIKVVIPVV SVQMIKKHKM
ARLLPNGLAI TTNTSQKYVF VSLLSRDSVY DMLRRVCTHL QPSSKKSLCV REFPEEPECE
SLEALIPEMK WRKVCPASRS VSLPDSIPCI SRASMESTDS FFPSREPLGS EISDCEEEKL
EEGPMSNREL KLWDYPLLKV FFVLICFLVM SSSYLAFRIS QLEQQLCSLN WGGSVPRHR
//
