ID G3N264_BOVIN Unreviewed; 285 AA.
AC G3N264;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Troponin T, cardiac muscle {ECO:0000256|ARBA:ARBA00041088};
DE AltName: Full=Cardiac muscle troponin T {ECO:0000256|ARBA:ARBA00042892};
GN Name=TNNT2 {ECO:0000313|Ensembl:ENSBTAP00000055971.2,
GN ECO:0000313|VGNC:VGNC:36195};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000055971.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000055971.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055971.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000055971.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055971.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin,
CC the thin filament regulatory complex which confers calcium-sensitivity
CC to striated muscle actomyosin ATPase activity.
CC {ECO:0000256|ARBA:ARBA00003363}.
CC -!- SIMILARITY: Belongs to the troponin T family.
CC {ECO:0000256|ARBA:ARBA00008330}.
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DR AlphaFoldDB; G3N264; -.
DR SMR; G3N264; -.
DR Ensembl; ENSBTAT00000065361.2; ENSBTAP00000055971.2; ENSBTAG00000045789.2.
DR VEuPathDB; HostDB:ENSBTAG00000045789; -.
DR VGNC; VGNC:36195; TNNT2.
DR GeneTree; ENSGT00940000154709; -.
DR HOGENOM; CLU_144507_0_0_1; -.
DR InParanoid; G3N264; -.
DR OMA; RIXEERA; -.
DR OrthoDB; 5362548at2759; -.
DR Reactome; R-BTA-390522; Striated Muscle Contraction.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000045789; Expressed in cardiac ventricle and 90 other cell types or tissues.
DR ExpressionAtlas; G3N264; baseline.
DR GO; GO:0097512; C:cardiac myofibril; IEA:Ensembl.
DR GO; GO:1990584; C:cardiac Troponin complex; IEA:Ensembl.
DR GO; GO:0005861; C:troponin complex; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR GO; GO:0005523; F:tropomyosin binding; IBA:GO_Central.
DR GO; GO:0030172; F:troponin C binding; IBA:GO_Central.
DR GO; GO:0031013; F:troponin I binding; IBA:GO_Central.
DR GO; GO:0060048; P:cardiac muscle contraction; IBA:GO_Central.
DR GO; GO:0030049; P:muscle filament sliding; IEA:Ensembl.
DR GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR GO; GO:0006937; P:regulation of muscle contraction; IEA:InterPro.
DR GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR GO; GO:0045214; P:sarcomere organization; IBA:GO_Central.
DR GO; GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR Gene3D; 1.20.5.350; -; 1.
DR InterPro; IPR027707; TNNT.
DR InterPro; IPR001978; Troponin.
DR InterPro; IPR038077; Troponin_sf.
DR PANTHER; PTHR11521; TROPONIN T; 1.
DR PANTHER; PTHR11521:SF5; TROPONIN T, CARDIAC MUSCLE; 1.
DR Pfam; PF00992; Troponin; 2.
DR SUPFAM; SSF90250; Troponin coil-coiled subunits; 1.
PE 3: Inferred from homology;
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..54
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 285 AA; 33897 MW; 312B446D02982499 CRC64;
MSDVEEAVEE YEEQEEAAEE EHEEAVEEEA GGEAEAGEPC TAEDGEEEEG REAEDGPVEE
FKPKPRPFMP NLVPPKIPDG ERVDFDDIHR KRMEKDLNEL QTLIEAHFEN RKKEEEELVS
LKDRIEKRRA ERAEQQRIRA EREKERQTRL AEERARREEE ESRRKAEDEA RKKKALSNMM
HFGGYIQKAQ TERKSGKRQT EREKKKKILA ERRKVLAIDH LNEDQLREKA KELWQNIYDL
EAEKFDLQEK FKQQKYEINV LRNRINDNQK VSKTRGKAKV TGRWK
//
