ID G3N2I0_BOVIN Unreviewed; 478 AA.
AC G3N2I0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=ETS transcription factor ELK4 {ECO:0000313|Ensembl:ENSBTAP00000056094.2};
GN Name=ELK4 {ECO:0000313|Ensembl:ENSBTAP00000056094.2,
GN ECO:0000313|VGNC:VGNC:28434};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000056094.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000056094.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056094.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000056094.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056094.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3N2I0; -.
DR SMR; G3N2I0; -.
DR STRING; 9913.ENSBTAP00000056094; -.
DR Ensembl; ENSBTAT00000063964.2; ENSBTAP00000056094.2; ENSBTAG00000004953.6.
DR VEuPathDB; HostDB:ENSBTAG00000004953; -.
DR VGNC; VGNC:28434; ELK4.
DR eggNOG; KOG3806; Eukaryota.
DR GeneTree; ENSGT00940000158900; -.
DR InParanoid; G3N2I0; -.
DR OMA; GDPEMPG; -.
DR TreeFam; TF317732; -.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000004953; Expressed in thymus and 111 other cell types or tissues.
DR ExpressionAtlas; G3N2I0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF21; ETS DOMAIN-CONTAINING PROTEIN ELK-4; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 25..105
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 132..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..293
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 478 AA; 52265 MW; DBD770A56AF38C10 CRC64;
MHLKCLKQYV IQCCLFQLIA MDSAITLWQF LLQLLKEPQN DHMICWTSNN GEFKLLQAEE
VARLWGIRKN KPNMNYDKLS RALRYYYVKN IIKKVNGQKF VYKFVSYPEI LNMDPMTVGR
VEGECEALSL SELSSSSSKD VENGGREKPP QPGAKTSSRN DYIHSGLYSS FTLNSLNSSN
RKLFKSIKVE NPAEKLAEKK SPQEPTPSVI KFVTTPSKKP PVESPAASIS AGPGISPSSE
ETIQALETLA SPRLPSLEAP TSASGVTAPF TTTPPVSSVS PLQEPPRTPS PPLSSNPDMD
TDMESVASQP MQLPENLSLE PKDQDLALLE KDKTNNSSRS KKPKGLELAP TLVITGSDPS
PLGILSPSLP TASLTPALFS QTPILLTPSP LLSSIHFWST LSPVAPLSPA RLQGANTLFQ
GPCWFLSPPR IMSPAKTRPG IFWTSLGGGG ALWLGLTSSW WNRSSLPRVQ GWECHVLV
//
