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Database: UniProt
Entry: G3N2S3_BOVIN
LinkDB: G3N2S3_BOVIN
Original site: G3N2S3_BOVIN 
ID   G3N2S3_BOVIN            Unreviewed;      1022 AA.
AC   G3N2S3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   24-JAN-2024, entry version 80.
DE   RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN   Name=NPR2 {ECO:0000313|Ensembl:ENSBTAP00000056191.2,
GN   ECO:0000313|VGNC:VGNC:106847};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000056191.2, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000056191.2, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056191.2,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000056191.2}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056191.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|RuleBase:RU003431};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
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DR   AlphaFoldDB; G3N2S3; -.
DR   Ensembl; ENSBTAT00000065432.2; ENSBTAP00000056191.2; ENSBTAG00000011434.6.
DR   VEuPathDB; HostDB:ENSBTAG00000011434; -.
DR   VGNC; VGNC:106847; NPR2.
DR   eggNOG; KOG1023; Eukaryota.
DR   GeneTree; ENSGT00940000156985; -.
DR   HOGENOM; CLU_001072_11_0_1; -.
DR   TreeFam; TF106338; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000011434; Expressed in uterine horn and 104 other cell types or tissues.
DR   ExpressionAtlas; G3N2S3; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd14042; PK_GC-A_B; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR001170; ANPR/GUC.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920:SF494; ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2; 1.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   PRINTS; PR00255; NATPEPTIDER.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00458; ANF_RECEPTORS; 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW   ECO:0000256|RuleBase:RU003431}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..1022
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018722820"
FT   DOMAIN          501..761
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          836..966
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   COILED          773..800
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1022 AA;  114405 MW;  BDC0680D285698F0 CRC64;
     MALPSLLLVV AALAGGVRPP GARNLTLAVV LPEHNLSYAW AWPRVGPAVA LAMEALGRAL
     PVDLRFVSSE LDGACSEYLA PLRAVDLKLY HDPDLLLGPG CVYPAASVAR FASHWRLPLL
     TAGAVASGFS AKSEHYRTLV RTGPSAPKLG EFVVMLHGHF NWTARAALLY LDARTDDRPH
     YFTIEGVFEA LQGSNLSVQH QVYAREPGGP EQATHFIRAN GRIVYICGPL EMLHEILLQA
     QRENLTNGDY VFFYLDVFGE SLRAGPTRSM GRPWQDNRTR EQAQALREAF QTVLVITYRE
     PPNPEYQEFQ NRLLIRARED FGVELAPSLM NLIAGCFYDG ILLYAEVLNE TIQEGGTRED
     GLRIVEKMQG RRYRGVTGLV VMDKNNDRET DFVLWAMGDL VSGDFQPAAH YSGAEKQIWW
     TGRPIPWVKG VPPLDNPPCA FDMDDPSCDK TPLSTLAIVA LGTGITFIMF GVSSFLIFRK
     LMLEKELASM LWRIRWEELQ FGNSERCHKG AGSRLTLSLG NVVAIKHVNK KRIELTRQVL
     FELKHMRDVQ FNHLTRFIGA CIDPPNICIV TEYCPRGSLQ DILENDSINL DWMFRYSLIN
     DLVKGMAFLH NSIIASHGSL KSSNCVVDSR FVLKITDYGL ASFRSTAEPD DSHALYAKKL
     WTAPELLSGN PLPTTGMQKA DVYSFGIILQ EIALRSGPFY LEGLDLSPKE IVQKVRNGQR
     PYFRPSIDRT QLNEELVLLM ERCWAQDPAE RPDFGQIKGF IRRFNKEGGT SILDNLLLRM
     EQYANNLEKL VEERTQAYLE EKRKAEALLY QILPHSVAEQ LKRGETVQAE AFDSVTIYFS
     DIVGFTALSA ESTPMQVVTL LNDLYTCFDA IIDNFDVYKV ETIGDAYMVV SGLPGRNGQR
     HAPEIARMAL ALLDAVSSFR IRHRPHDQLR LRIGVHTGPV CAGVVGLKMP RYCLFGDTVN
     TASRMESNGQ ALKIHVSSTT KDALDELGCF QLELRGDVEM KGKGKMRTYW LLGERKGPAG
     LL
//
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