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Database: UniProt
Entry: G3N6J0_GASAC
LinkDB: G3N6J0_GASAC
Original site: G3N6J0_GASAC 
ID   G3N6J0_GASAC            Unreviewed;       617 AA.
AC   G3N6J0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   10-APR-2019, entry version 41.
DE   RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000915, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000000915}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000000915}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU046415}.
CC       Nucleus {ECO:0000256|RuleBase:RU046415}.
CC   -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC       {ECO:0000256|RuleBase:RU046415}.
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DR   Ensembl; ENSGACT00000000915; ENSGACP00000000915; ENSGACG00000000707.
DR   eggNOG; KOG3667; Eukaryota.
DR   eggNOG; ENOG410XPN8; LUCA.
DR   GeneTree; ENSGT00950000182688; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.532.10; -; 1.
DR   Gene3D; 2.60.40.630; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001217; STAT.
DR   InterPro; IPR036535; STAT_N_sf.
DR   InterPro; IPR013800; STAT_TF_alpha.
DR   InterPro; IPR015988; STAT_TF_coiled-coil.
DR   InterPro; IPR013801; STAT_TF_DNA-bd.
DR   InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR   InterPro; IPR013799; STAT_TF_prot_interaction.
DR   PANTHER; PTHR11801; PTHR11801; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF01017; STAT_alpha; 1.
DR   Pfam; PF02864; STAT_bind; 1.
DR   Pfam; PF02865; STAT_int; 1.
DR   SMART; SM00964; STAT_int; 1.
DR   SUPFAM; SSF47655; SSF47655; 1.
DR   SUPFAM; SSF48092; SSF48092; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU046415};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007635};
KW   Cytoplasm {ECO:0000256|RuleBase:RU046415};
KW   DNA-binding {ECO:0000256|RuleBase:RU046415};
KW   Nucleus {ECO:0000256|RuleBase:RU046415};
KW   Phosphoprotein {ECO:0000256|RuleBase:RU046415};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191,
KW   ECO:0000256|RuleBase:RU046415};
KW   Transcription {ECO:0000256|RuleBase:RU046415};
KW   Transcription regulation {ECO:0000256|RuleBase:RU046415}.
FT   DOMAIN      505    617       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   COILED       86    113       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   617 AA;  71290 MW;  164BE641997EDD3D CRC64;
     MALFQVLLEN LDIQHSRFVQ EESFLLQHNI RRRKQNFQGY LDDPCALANT ILWFLKKEKE
     ILQSADLAEQ VQLLHVAEEA METSSQLDIE RKIAGLRNEV ECMERTMSCL EEQQDEFDFK
     FQTYKMEAVV DEAAKRKQMQ VFQQLINRLD ECRKSTLSEL NKLLDRTDTL IDILVKKELV
     EWHRMQQKAC IGAPENVCLD QLEKWFTYVA VCLFRVREFL DKLEELVGKV SYQNDPVKSQ
     KPKMQKRAET LLKDLLQSSF VVETQPCMPQ GKGPLVLRTN VQFAVKTRLL VKFPELNHSM
     KVNVCMDRYR RFNVFGTKSK ALNMAESQSG GMVADFRHLT LKEQKSGGGG KGINDISLSV
     TEELHIIHFD TLFEMKGLSI ELQASSIPVV IISNSSQQQS ACASVLWFNM LSVDTKDVMF
     FANSPAATWP QFGDMLSWQF LSATKRGLNE AQLEMIAQRL FGKQQTYDTC KVTWSKFSKE
     NTPDTFWAWF DGILVMVKTY LEDLWRDGLI MGFVSKSKEK YLLKKKQRGT FLLRFSESVI
     GAITFSWVEI DMNGEPDVKT VQPFNKVDLC QIPFQEIIRN FQILEAENIP ESPLLYLYPN
     TPKDEAFGKY YCEKTGS
//
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