ID   G3N9T1_GASAC            Unreviewed;       586 AA.
AC   G3N9T1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=Inter-alpha-trypsin inhibitor heavy chain 3 {ECO:0008006|Google:ProtNLM};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002072.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000002072.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000002072.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; G3N9T1; -.
DR   STRING; 69293.ENSGACP00000002072; -.
DR   Ensembl; ENSGACT00000002077.1; ENSGACP00000002072.1; ENSGACG00000001585.1.
DR   eggNOG; ENOG502QPS2; Eukaryota.
DR   GeneTree; ENSGT00940000154554; -.
DR   InParanoid; G3N9T1; -.
DR   OMA; KNAFVPR; -.
DR   TreeFam; TF328982; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000001585; Expressed in liver and 2 other cell types or tissues.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10338:SF156; INTER-ALPHA (GLOBULIN) INHIBITOR H3-RELATED; 1.
DR   PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT   DOMAIN          1..127
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          253..431
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          565..586
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        567..586
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   586 AA;  65633 MW;  242F2EC0087ED581 CRC64;
     NVTPPVFAQA DWDIYSFHIN STVSSRYATT VITSRVANRM NDSKEIEFHV RIPKNAFISK
     FRMLIDGQFY DGVVKGKEKA QQQYTEAVSR GQSAGLVSSV GRTMEKFKTS VTLAAHKKVT
     FELTYEELLK RRLGKYELQI HARPMQPVKD FKVDVYINEK AGINFMEVKG GLNTKALANA
     ITRTHLDKQA WVYFYPTEDQ QKTCDSCGEQ GMNGDLVIVY DVNRNPSLGD IKKSGRYFVH
     HFAPSNLASI PKNVVFVIDQ SGSMHGRKML QTRIALIHIL SDLAEEDHFG LITFDSQVFH
     WKRELVQATK GNLESAKTFA RQIVERGSTD ISRAVLEGTR MLNAHPREGS ASLLILLTDG
     DPTSGETNPE VIQSNVRRAI AGKFPLYCLG FGFDVNFEFL EKMSLQNNGV ARRIYEDSDA
     DLQLTGFYNE VATPLLTDVT MIYNGGANLT ETNFSRYYNG SEIVVAGQIT DNDIETFTPQ
     VVAISSNRRV TFSDINATVE SVEDASDSSI QRVWAYLTVK QLLEKELVLS GPEKENAKKE
     ALDLSLKYSF VTPLTSMVVT KPQGEITDVL HKPREGKNKE GKSLHS
//