ID   G3NA03_GASAC            Unreviewed;      1094 AA.
AC   G3NA03;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=Nonsense-mediated mRNA decay factor {ECO:0000256|RuleBase:RU369098};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002145.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000002145.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000002145.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Plays a role in nonsense-mediated mRNA decay.
CC       {ECO:0000256|RuleBase:RU369098}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369098}.
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DR   AlphaFoldDB; G3NA03; -.
DR   Ensembl; ENSGACT00000002151.1; ENSGACP00000002145.1; ENSGACG00000001634.1.
DR   GeneTree; ENSGT00940000158333; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000001634; Expressed in telencephalon and 13 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR   InterPro; IPR019458; Est1-like_N.
DR   InterPro; IPR045153; Est1/Ebs1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR15696:SF5; NONSENSE-MEDIATED MRNA DECAY FACTOR SMG7; 1.
DR   PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1.
DR   Pfam; PF10374; EST1; 1.
DR   Pfam; PF10373; EST1_DNA_bind; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161,
KW   ECO:0000256|RuleBase:RU369098}; Nucleus {ECO:0000256|RuleBase:RU369098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT   DOMAIN          55..167
FT                   /note="Telomerase activating protein Est1-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10374"
FT   DOMAIN          170..429
FT                   /note="DNA/RNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF10373"
FT   REGION          496..635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          702..781
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          967..1017
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1046..1078
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          261..292
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        504..541
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        546..626
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        703..768
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        967..1001
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1047..1078
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1094 AA;  121058 MW;  DA0F73EE55ADA682 CRC64;
     RMNVCAQYLR QAEALKADMT DSKLGAAEVW TSRQALQDLY QKMLVTDLEY ALDKKVEQDL
     WNHAFKNQIT TLQSQAKNRA NPNRSEVQAN LSLFLEAASG FYTQLLQELC TVFNVDLPCR
     VKSSQLGIIS NKQGGGAIVT PQPSSCSYIC QHCLVHLGDI ARYRNQTSQA ESYYRHAAQL
     VPSNGQPYNQ LAILASSKGD HLSTIFYYCR SIAVKFPFPA ASTNLQKALS KALESRDEVK
     TKWSVSDFVR AFIKFHGHVY LSKSLEKLDL LREKLEEQFQ RLTLQKAFSS QQLVHITVIN
     LFELHHLRDL TAEGSEQIFN GEQQVGWFQL LGLFMSFLGV MCSRVILNNS RGEEIMGECP
     LPAIKVSLDW LKLRPSIFPE AAMDQRQHVW PWLVSILNSF QPREDTVSFS SVTPLPEEFE
     LQGFLALRPA LRSLDFTKGH QGVLVDRDGL PVHTRHQRLI SLGRWVADNQ PGLIQCKVSE
     DGLLVFITDI PEQAVEEPLE KETPVLQESS NAEQTANDGG NCGLKSVLSA GKTQSSWPDG
     SERPVVTFKE NIKPREQSRE PTRSLPLKDS GKERRDFTKG NAAAGKGEPK RDGKRKSELK
     KAGHEKAADA VKQVKAQTEM RKTPVPEAKK TPVTQMQTTC SSQFIPTIHH PGAFPPLPSR
     PGSFPPSAYV IPPPVAFPGL QVNPGFTFPA GVTVPGAFLQ PGVHTQTAGQ SGKPSHIPYS
     QQRPSGPGPG QGPGSSCPPQ GQQPQNQAMQ SVQLQAMSQQ SPTKPVQQVG MGKSPPHHPG
     LQQFMQVQDQ PAQMWNQAQA ALQKIPPVPM SMKQPQQQQQ QAAFYMAAQD PLKLYEHQMD
     KKMKFPNVKI QDFYWEPTYR VGDGLAVMAD QSSNNQILET QIAEKYVSRR RAATRQLPNQ
     TRMESGAEVV SSSLLPMSGF PMQEYNQNSI FSQAYGKSLP PCSKPDAPMM HQEPSLYSLF
     EGTPWSPSLP ASSDHSTPAS QSPHSSNPSS LPSSPPTHNH GAVPFSNFGP IGTPDSRDRR
     MVDRWKADKT GWAVSGFGLD YLPAPPSSAA SDTSWHQAGP TGNSWTNQES PMEESSSTVL
     LDSLKSIWSS SMMH
//