ID G3NBR4_GASAC Unreviewed; 920 AA.
AC G3NBR4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Neutral sphingomyelinase (N-SMase) activation associated factor {ECO:0000313|Ensembl:ENSGACP00000002761.1};
GN Name=NSMAF {ECO:0000313|Ensembl:ENSGACP00000002761.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002761.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000002761.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000002761.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3NBR4; -.
DR STRING; 69293.ENSGACP00000002761; -.
DR Ensembl; ENSGACT00000002771.1; ENSGACP00000002761.1; ENSGACG00000002116.1.
DR eggNOG; KOG1786; Eukaryota.
DR GeneTree; ENSGT00940000155059; -.
DR InParanoid; G3NBR4; -.
DR OMA; LLKFPGC; -.
DR TreeFam; TF324912; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000002116; Expressed in spleen and 13 other cell types or tissues.
DR GO; GO:0002233; P:leukocyte chemotaxis involved in immune response; IEA:Ensembl.
DR GO; GO:0002232; P:leukocyte chemotaxis involved in inflammatory response; IEA:Ensembl.
DR GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR CDD; cd06071; Beach; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF162; PROTEIN FAN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 186..283
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 287..572
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 712..742
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 761..802
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 803..844
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 884..920
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 566..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 920 AA; 104356 MW; 49E56B47DAFA833F CRC64;
TRFTLVVHEH DLTLLLFSSR FSLLLLDLEE YYFEQHTAYY ATTSSNKEKK VRGSLKVCSR
SIIFDPEDLT EPILKITLRD CKKIEFLDRE NNPFHEPRPS AISILCVQVI YIKESNVIAP
YRNERGAKKV SFQLEGWSKT EDVVQTLLQL HRASCLEKLG DQTAMIAANL QSRLARSFFD
KNCFQSVAEK PHMECAVEMV MPLVSNPGHV CITDESLYFQ PLNGYPEQVI QIQLHRVRRI
YKRRHGLRPL GLEVFCTEND FCSDIYLKFY KTADRDEIYY YIATFLENHV TEHTAESYML
QWQRGHLSNY QYLLHLNNLA DRSCNNLSQY PVFPWVISDY ASERLDLTNA ATFRDLSKPV
GALNRERLDQ LLARYRGMPE PRFMYGSHYS SPGYVLFYLV RVAPEHMLCL QNGRYDHADR
MFNSIGDTWK NCLEGATDFK ELIPEFYGTD CGFLENKLRL DLGRRQNGSL VGDVVLPPWA
SDTGDFLQKH RTALESQYVS EHLHEWIDLV FGFKQRGGEA LAAHNVFHPL TYEGGIDCDS
IEDPDQRIGM LTQILEFGQT PKQLFTTPHP QRITPRFHNI TRSPSSNSPV GDLSPASQSE
DSSFEDLTEE SRKLAWANMG NLKPISSHKI HKEAVTGIAV SHDGSAIFST SQDTTLKMFS
KELKDFQRSM SFSNMALSSC LMLADGKTVV CSSWDNHVYF YSVPFGRRQD TLMGHDDAVS
KMCWFDDRLY TASWDSTVKV WQCASDGSSS HKRSQFQLLA ELEHDAGVNT IGLNPAGTLL
VSGCKDGAVT IWDTSSHATL QQIHCHTGTI HHVAFSPDSR HVLSVGADSC MKVTDVQTGM
VISTVKAVEE QRCFCWDGNL VLCGGQSGDL LLWDLLSNTV IQRIPAHSGA VTAMWMSELC
STVITGGDDR QIILWKLLSP
//
