ID G3NCE5_GASAC Unreviewed; 867 AA.
AC G3NCE5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Cadherin-1 {ECO:0000256|ARBA:ARBA00023893};
DE AltName: Full=Epithelial cadherin {ECO:0000256|ARBA:ARBA00032684};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000002994.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000002994.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000002994.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
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DR AlphaFoldDB; G3NCE5; -.
DR Ensembl; ENSGACT00000003005.1; ENSGACP00000002994.1; ENSGACG00000002297.1.
DR GeneTree; ENSGT00940000154848; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000002297; Expressed in intestinal epithelial cell and 9 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 3.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR014868; Cadherin_pro_dom.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF319; CADHERIN-1; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08758; Cadherin_pro; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 4.
DR SMART; SM01055; Cadherin_pro; 1.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..867
FT /note="Cadherin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003448306"
FT TRANSMEM 690..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 141..248
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 249..360
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 361..473
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 474..581
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 867 AA; 94805 MW; 802E81B03CB80774 CRC64;
MGTARVALWG ILIVAFQASA LVPTEKPTCV PGFQSDMLVY QVVRKHLRLG TRLGKEIPVG
FSDCTERRAF PFHSDDGHFT VQRDGVLKVK RPIDIHRHRE FTIHSWDSEG HRHLLRSTTD
QQVPILQFAK SVEGLRRRKR DWVIPPLSVP ENSRGPYPLK VAQIRSSEDK VKKIYYSITG
PGATEAPKGI FTIDRDSGNL YVTQPLDREA KESYMFEAHA VADGAGTAEQ PMEIIVNVID
QNDNKPVFAQ STFLGEVAES SPGGSTVIKI EAKDLDEPNN DNSDIRYSIQ SQDPTLPSDP
LFAINPITGV IRVNAGGLDR EKYPKYTLVV RAADLRGEGL SGEAKVILTV TDSNDNAPAF
TQPAYEASVE ENKIDAHVIT MSVTDGDEPL SAAWNAVFTI VAGDPGGLFT VKTTESNKHE
GIISTAKALD FERSTQHTLL VAVVNEVPFA IPLLTATTTV VVTVVDVNEA PIFNPIEKQV
SKREDLAVGS EVVQYTASDP DTARKQIVTY RIIRDPAGWL SVAKDTGLIK VKSLMDREGS
FVKDNKYTAL IGASDNDDVP ATGTGTLIIQ LEDVNDNAPT IEERSIRLCH KDSAPQLLSV
TDKDGPGFAA PYSVSLHGPS KTNWTARMND SKTGIVLNLA TVLDSGEYTV VLRVADNQGM
AQDSTVLATV CDCTGEEVTC KGRAVAGSEL PVILGILGGI LLLLMLVLLL LFFARRRRGE
QKVPLLQEDD IRDNVYYYDE EGGGEDDQDY DLGVLHRGLD NRPEVFRNDV VPNFMPAPQY
RPRPANPEEI GNFIDDNLKA ADNDPTAPPY DSLLVFDYEG GGSDAGSIST LNSSSSGDQD
YNCLNEWGPR FKKLADMYGG GEDDDML
//
