ID   G3NCJ6_GASAC            Unreviewed;       114 AA.
AC   G3NCJ6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Transmembrane protein 14C {ECO:0000256|ARBA:ARBA00039421};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000003046.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000003046.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000003046.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Required for normal heme biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00037428}.
CC   -!- SIMILARITY: Belongs to the TMEM14 family.
CC       {ECO:0000256|ARBA:ARBA00007590}.
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DR   AlphaFoldDB; G3NCJ6; -.
DR   Ensembl; ENSGACT00000003057.1; ENSGACP00000003046.1; ENSGACG00000002339.1.
DR   GeneTree; ENSGT00940000154772; -.
DR   OMA; MGSRWAR; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000002339; Expressed in muscle tissue and 13 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.1740; Transmembrane protein 14-like; 1.
DR   InterPro; IPR005349; TMEM14.
DR   InterPro; IPR044890; TMEM14_sf.
DR   PANTHER; PTHR12668; TRANSMEMBRANE PROTEIN 14, 15; 1.
DR   PANTHER; PTHR12668:SF4; TRANSMEMBRANE PROTEIN 14C-RELATED; 1.
DR   Pfam; PF03647; Tmemb_14; 1.
PE   3: Inferred from homology;
KW   Heme biosynthesis {ECO:0000256|ARBA:ARBA00023133};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        13..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        38..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        90..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   114 AA;  11602 MW;  D4B740829DAB764C CRC64;
     FSPSPVSSMS TDYVGYGYAA LIASGGAIGY FKAGSTPSLA AGLLFGGLAG FGAYQISNDP
     KNIWVSLATS GALTAVMGKR FYGSRKLMPA GLMAGASLLM VGKLALTLLQ KPQE
//