ID G3NE50_GASAC Unreviewed; 740 AA.
AC G3NE50;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Exostosin-1c {ECO:0000313|Ensembl:ENSGACP00000003601.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000003601.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000003601.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000003601.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC {ECO:0000256|ARBA:ARBA00010271}.
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DR AlphaFoldDB; G3NE50; -.
DR STRING; 69293.ENSGACP00000003601; -.
DR Ensembl; ENSGACT00000003613.1; ENSGACP00000003601.1; ENSGACG00000002741.1.
DR eggNOG; KOG1021; Eukaryota.
DR GeneTree; ENSGT00940000163960; -.
DR InParanoid; G3NE50; -.
DR OMA; RNRYMWN; -.
DR TreeFam; TF314231; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000002741; Expressed in testis and 3 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050508; F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0050509; F:N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR InterPro; IPR004263; Exostosin.
DR InterPro; IPR040911; Exostosin_GT47.
DR InterPro; IPR015338; GT64.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR Pfam; PF03016; Exostosin; 1.
DR Pfam; PF09258; Glyco_transf_64; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 107..390
FT /note="Exostosin GT47"
FT /evidence="ECO:0000259|Pfam:PF03016"
FT DOMAIN 475..723
FT /note="Glycosyl transferase 64"
FT /evidence="ECO:0000259|Pfam:PF09258"
SQ SEQUENCE 740 AA; 86026 MW; E47D0F5B30349B59 CRC64;
MQARKKYGLL GLCACCWLVL FYWGGGVQLR LLRLLTRQPG EVVRPWPNWT DRAFLPRYAH
LDEIQMDPGT GELPHQRRHA WSAVYKDSRC RMETCFDFSR CRRRGREGFR VYMYPSEKSD
RVSESYRKIL ASIAESRYYT SDPREACLFV LGIDTLDRDQ LSGQFVPNMD ERIRGFPLWN
DGRNHLIFNL YSGTWPNYTE DLGFNIGQAI LAKASLNTEH FRPGFDVSIP LFSKDHPQKG
GDRGWLVRNT IPPRRKYLLM FKGKRYLTGI GSDTRNALHH IHNGKDIVSL TTCRHGKDWE
KHKDARCDHD NLEYERFDYQ ELLHNSTFCL VPRGRRLGSF RFLESLQAAC IPVLLSNGWE
LPFSDVIQWN QAVIEGDERL LLQVPSTVRA VGNERVLALR QRTQMLWEAY FSSVDKIVLT
TLEIIKDRVF SHISRNKYMW NSLPGGLLVL PEYSTHLTHF PFYYLGLGVS PGQEFTAVIH
AVSPLVSQSQ PIMKLLQVVS KSKYCSQIII LWNSEKPPPS RSKWPPMPVP LTVTDGRRKT
TSRFLPHVAI ETEAVLSLDE DTVLLTNEVN FAFLVWRSFP ERIVGYPPRS HFWDPLKGAW
GYTSKWTNDY SIVLTGAAFY HRYYHYLFSH YLPQSLRTLV DRTSNCEDIL MNFLVSAVTH
LPPIKVAQRK QYKELPSPQS TKSVPWANPE HFNQRQECVN TFANWFGYMP LVHSQFRLDP
VLFKDQVSVL RKKYKDLERA
//
