ID G3NE68_GASAC Unreviewed; 910 AA.
AC G3NE68;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR005813};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000003619.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000003619.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000003619.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR005813, ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR005813}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|PIRNR:PIRNR005813,
CC ECO:0000256|RuleBase:RU003756}.
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DR AlphaFoldDB; G3NE68; -.
DR STRING; 69293.ENSGACP00000003619; -.
DR Ensembl; ENSGACT00000003631.1; ENSGACP00000003619.1; ENSGACG00000002745.1.
DR eggNOG; KOG0219; Eukaryota.
DR GeneTree; ENSGT00550000074867; -.
DR InParanoid; G3NE68; -.
DR OMA; LVRFPQK; -.
DR TreeFam; TF351780; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000002745; Expressed in embryo and 5 other cell types or tissues.
DR GO; GO:0032301; C:MutSalpha complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03285; ABC_MSH2_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR032642; Msh2_ATP-bd.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR005813};
KW DNA repair {ECO:0000256|PIRNR:PIRNR005813, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR005813};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR005813};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 717..733
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 826..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 527..554
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 838..852
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 910 AA; 101131 MW; C13B958C7A801506 CRC64;
MPEKPDTTFR IFDRNDYYTV HGKDAVFAAK EVFKTNGVIK YLGSGSRRLE SVVLSKLNFE
AFVKDLLLVR QYRVEVYKNH SKSSKEHDWK VDYKASPGNL TQFEEILFGG GTGAVGCTGV
VAVRFATGAD GQRVVGVGYV DAAQRTMGVC EFPDNEIFSN LESLLVQISP KECLLAQGEN
NTDSGKLREV VQRGGILISD RKRAEFSSKN MIQDLNRLLR AKRGETVASN TLPELDKQVA
MSCLAAVVRF LDLLSDESNF NSFSLTALDL GQYMRLDNAA VRALNLFQGS PDDTSGAHSL
AGLLNKCRTP QGQRLVNQWI KQPLMDKTKI EERLDLVESF VCDSELRQTC QEDLLRRFPD
LHRLAKKFHR YSASLQDCFR VYQAVSHVPA LVSALERYSG SYQVLLDAAF ISPLRDLQTD
FVKYQEMIET TLDMNQIDHH EFLVKASFDP ALSELRENMD ALEKSMQAVL SGAARELGLD
AGKTVKLESN AMLGFYLRVT CKEEKSLRNN KKFTTLDVQK NGVRFTNSKL SSLNEEYTKN
RAEYEEAQNA IVKEIINIAS GYVDPLQTLS DVTAQMDAVA SFAVASVSAP VPYVRPRLVA
DGRRRVELRQ ARHPCMETDA DTAFIPNDVS FAQGEKDFYI ITGPNMGGKS TFIRQVGVIA
LMAQIGCFVP CEKAELSVID SILARVGAGD SQVKGVSTFM SEMLETAAIL RSATENSLII
IDELGRGTST YDGFGLAWAI SEHIASEIGC FCLFATHFHE LTALAAQRPA VHNLHVTALT
SHDTLTMLYR VKSGVCDQSF GIHVAELACF PPSVIAVAKE KAEELEEFQE PAGEKSEQEE
EPEAKRRRTD RQVGENLIQD FLEKAKSLPA ATMSEEEVKD ALRKMKQELV AKNNTYIKEI
LSRCVPAKTA
//
