ID G3NGE1_GASAC Unreviewed; 408 AA.
AC G3NGE1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Synaptotagmin {ECO:0000256|RuleBase:RU367154};
GN Name=SYT2 {ECO:0000313|Ensembl:ENSGACP00000004397.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000004397.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000004397.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000004397.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May have a regulatory role in the membrane interactions
CC during trafficking of synaptic vesicles at the active zone of the
CC synapse. It binds acidic phospholipids with a specificity that requires
CC the presence of both an acidic head group and a diacyl backbone.
CC {ECO:0000256|RuleBase:RU367154}.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|RuleBase:RU367154};
CC Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2
CC domains. {ECO:0000256|RuleBase:RU367154};
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle membrane {ECO:0000256|RuleBase:RU367154}; Single-pass membrane
CC protein {ECO:0000256|RuleBase:RU367154}.
CC -!- SIMILARITY: Belongs to the synaptotagmin family.
CC {ECO:0000256|ARBA:ARBA00006996, ECO:0000256|RuleBase:RU367154}.
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DR AlphaFoldDB; G3NGE1; -.
DR STRING; 69293.ENSGACP00000004397; -.
DR Ensembl; ENSGACT00000004411.1; ENSGACP00000004397.1; ENSGACG00000003359.1.
DR eggNOG; KOG1028; Eukaryota.
DR GeneTree; ENSGT00940000157586; -.
DR InParanoid; G3NGE1; -.
DR OMA; SPYVKIN; -.
DR TreeFam; TF315600; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000003359; Expressed in diencephalon and 2 other cell types or tissues.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR CDD; cd08402; C2B_Synaptotagmin-1; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001565; Synaptotagmin.
DR PANTHER; PTHR10024; SYNAPTOTAGMIN; 1.
DR PANTHER; PTHR10024:SF223; SYNAPTOTAGMIN-2; 1.
DR Pfam; PF00168; C2; 2.
DR PRINTS; PR00360; C2DOMAIN.
DR PRINTS; PR00399; SYNAPTOTAGMN.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU367154};
KW Cytoplasmic vesicle {ECO:0000256|RuleBase:RU367154};
KW Membrane {ECO:0000256|RuleBase:RU367154};
KW Metal-binding {ECO:0000256|RuleBase:RU367154};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|RuleBase:RU367154};
KW Transmembrane {ECO:0000256|RuleBase:RU367154};
KW Transmembrane helix {ECO:0000256|RuleBase:RU367154}.
FT TRANSMEM 67..88
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367154"
FT DOMAIN 123..247
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 259..392
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 408 AA; 45462 MW; 3CF68CBDFFD14179 CRC64;
KWNLFKHQTT PMVVANPTGA SALTVTPAPV ALVSTDNSTE PVEKNDGFDE IKNKFLNEID
KIPLPPWAII AIAVVAALLI LTCCFCIIKK CCCEMGMKNL KGGEEDSHRK VGHDEMLSMG
NRRKTEESLG VRCSCDSFQV CKFTVLMSGK GELPEVFAWL LLGCSIMHLM LPPQKKQKTT
TQRVHKKTLY LTFNGAISLQ IPFQEMGGKT LVMSVYDFDR FSKHDVIGEI KIPMNTLDLA
KPIEEWKDLD SADQEEPEKL GDICISLRYV PTAGKLTICI LEAKNLKKMD VGGLSDPYVK
INLLQNGKRL KKKKTTVKKN TLNPYYNESF SFEIPIDQMQ KILAVITVLD YDKIGKNDAI
GKILVGSKST GAGLKHWSDM LANPRRPIAQ WHPLQPEEEV DAALAALN
//