ID G3NHF4_GASAC Unreviewed; 1689 AA.
AC G3NHF4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Kinesin family member 1Aa {ECO:0000313|Ensembl:ENSGACP00000004762.1};
GN Name=KIF1A {ECO:0000313|Ensembl:ENSGACP00000004762.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000004762.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000004762.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000004762.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR STRING; 69293.ENSGACP00000004762; -.
DR Ensembl; ENSGACT00000004776.1; ENSGACP00000004762.1; ENSGACG00000003623.1.
DR eggNOG; KOG0245; Eukaryota.
DR GeneTree; ENSGT00940000156474; -.
DR InParanoid; G3NHF4; -.
DR OMA; YEASLCH; -.
DR TreeFam; TF105221; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000003623; Expressed in telencephalon and 2 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF2; KINESIN-LIKE PROTEIN KIF1A ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 5..355
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 517..573
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 1574..1672
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 945..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1524..1555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 431..458
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 629..678
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 954..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 96..103
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1689 AA; 190905 MW; 73F3BFA5C1FDE3ED CRC64;
MAGASVKVAV RVRPFNSREI GKDSKCIIQM SGNTTTIVNP KQAKDNKSFN FDYSYWSHTS
PEDINYASQV QVYKDIGEEM LLHAFEGYNV CIFAYGQTGA GKSYTMMGKQ DVKDQQGIIP
LLCEDLFTKF NDNGDNSMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLMGPYVED
LSKLAVTSYN DIQDLMDSGN KARTVAATNM NETSSRSHAV FNIIFTQKRH DAETDNTSEK
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVDS GSNKNKKKKK
VESFIPYRDS VLTWLLRENL GGNSRTAMIA ALSPADINYD ETLSTLRYAD RAKQIRCNAV
INEDPNNRLV RELKEEVSRL KDLLFSQGLG DIIDMTNAMT GMSPSPSLSA LSSRAGSIAS
LHDRIMFSPG SEEAIERLKE TEKIIAELNE TWEEKLRRTE AIRMEREALL AEMGVAMRED
GGTVGVFSPK KTPHLVNLNE DPLMSECLLY YIKDGVTRVG RVDAASRQDI VLSGHFIKDE
HCTFTSSTDK AREIVVVLEP CEGAETYVNG KRVTEPTVLK SGNRIILGKS HVFRFNHPVQ
ARAERERTPC AETPAEPVDW AFAQRELLDK QGIDMKQEME QRLQELEDQY RKEREETNNL
LEQQRLDYES KLEALQKQVD SYYPETLEEE EEPEEEVQWT ERERELAVWS FRKWRCYQFT
SLRDLLWGNA IFLKEANAIS VELKKKVQFQ FVLLTDTLYS PLPPDLLPPE AAKDREKRHF
PRTIVAVEVQ DQKNGATHYW TLEKLRQRLD LMREMYDRAA DVPNNTAEDG ENVMTGGDPF
YDRFPWFRLV GRAFVYLSNL LYPVPLVHRV AIVSERGEVK GFLRVAVQAI SADEEAPDYG
SGVRQSGTAK ISFEDQQYEK FQSETCSVGL PRSGASQEEL RFVEGEGQNA EPGPSADEVN
NNTCAAGTDE AESPLKSQGG PLDTTLEHLR VGNVFTFRVT VLQASSIPAE YADIFCQFNF
IHRHDEAFST EPLKNTGRGP PLGFYHVQNI AVEVTKSFVD YIKSQPIVFE VFGHYQKQPF
LPLCKDVISP LRPCRRQFPR VMPLSKPDTV PATKLTAMTR PQAGPCHSKH DLMVFFEICE
LEATGDYIPA VVDHRGGMPC HGTFLLHQQP QGLQRRVTVT IVHESGGDME WKDIRELVVG
RLRNTPEADE TIIDPNILSL NILSAGYVRP MRDDRQFLDS DMPRTFYRFE AAWDSSMHNS
LLLNRVTPYG EKIYMTLSAY LEMENCTQPA IITKDVCMVF YSRDTKLSAS RSIRNLFGTG
SLRAADGNRV TGVYEVSLCN LADAGSPGMQ RRRRRVLDTS VAYVRGEENL AGWRPRSDSL
ILDHQWELEK LSLLQDVEKT KHYLLLREKL ESTMLMGQES LQSCITEELS ECPQPPEVDQ
EVPSRSEITT ERQRELAAKC LRLLTHSFNR EYSHVCVSAS ESKISEMSVT MLRDSASISA
LNTITPSSTC PSLVEGCYGD AELRPPMPRS RAASPAPAPQ QDTEAKKSAG GASETKPRIR
RFFPDITEIR VSPIVSKKGY LHFLEPNTNG WVKRYVVVRR PYVYIYNAER DSVERAILNL
SSAQVEYSED QQAMLKTPYT FAVCTEHRGI LLQATNDKEM HDWLYAFNPL LAGTIRSKLS
RRRAGPMRM
//
