ID   G3NHR2_GASAC            Unreviewed;       443 AA.
AC   G3NHR2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=Solute carrier family 41 member {ECO:0000256|RuleBase:RU369007};
GN   Name=SLC41A3 {ECO:0000313|Ensembl:ENSGACP00000004872.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000004872.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000004872.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000004872.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Acts as a magnesium transporter.
CC       {ECO:0000256|RuleBase:RU369007}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU369007}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369007}.
CC   -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC       {ECO:0000256|ARBA:ARBA00009749, ECO:0000256|RuleBase:RU369007}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU369007}.
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DR   AlphaFoldDB; G3NHR2; -.
DR   Ensembl; ENSGACT00000004886.1; ENSGACP00000004872.1; ENSGACG00000003711.1.
DR   eggNOG; KOG3788; Eukaryota.
DR   GeneTree; ENSGT00950000183042; -.
DR   InParanoid; G3NHR2; -.
DR   OMA; NLEFCFQ; -.
DR   TreeFam; TF313647; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000003711; Expressed in liver and 9 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030001; P:metal ion transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 2.
DR   InterPro; IPR006667; SLC41_membr_dom.
DR   InterPro; IPR036739; SLC41_membr_dom_sf.
DR   InterPro; IPR045349; SLC41A1-3.
DR   PANTHER; PTHR16228; DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41; 1.
DR   PANTHER; PTHR16228:SF22; SOLUTE CARRIER FAMILY 41 MEMBER 3; 1.
DR   Pfam; PF01769; MgtE; 2.
DR   SUPFAM; SSF161093; MgtE membrane domain-like; 2.
PE   3: Inferred from homology;
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU369007};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU369007};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369007};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU369007};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU369007};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU369007}.
FT   TRANSMEM        37..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   TRANSMEM        122..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   TRANSMEM        157..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   TRANSMEM        194..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   TRANSMEM        224..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   TRANSMEM        377..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   TRANSMEM        413..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369007"
FT   DOMAIN          80..214
FT                   /note="SLC41A/MgtE integral membrane"
FT                   /evidence="ECO:0000259|Pfam:PF01769"
FT   DOMAIN          293..430
FT                   /note="SLC41A/MgtE integral membrane"
FT                   /evidence="ECO:0000259|Pfam:PF01769"
SQ   SEQUENCE   443 AA;  47879 MW;  025EA4AFC77C47F5 CRC64;
     MVVTRLELEL RYQGKKLRGV TWKLTRSEHG FIPESSWLIA AQVIVPYLVS GLGLVSAGIV
     MDLIQHWKVF KVITEVFILV PALVGLKGNL EMTLAARLST AANTGQMDDP DKQWTMVCSN
     LALIQVQATV VGFLAAVAAV CLGSFSRGGV ELDQAAVLCA SSITTAFVAA LSLGLVMIGV
     IIGSRKVGIN PDNVATPIAA SLGDLITLSL LAGVSSTLYE YIDVWYLSPL VCLVFLALIP
     IWVVVARRSP QIREVLRSGW QPVIVAMSIS SFGGLILDRT VSDPNFKGMA VFTPVINGVG
     GNLVAIQASR ISTYLHFWSI PGVLPYKMRQ HWPNPCISFF SSGNLGSLKS DLCSCEIITL
     NLISIYASKD LSTKFTVCYL CAALLQVAIL LYFADLIIRA MWRRSLDPDN FSIPYLTALG
     DLLGTGFLAL CFRSVSLVQS LGL
//