ID G3NHY9_GASAC Unreviewed; 2123 AA.
AC G3NHY9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Plexin b1a {ECO:0000313|Ensembl:ENSGACP00000004949.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000004949.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000004949.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000004949.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR STRING; 69293.ENSGACP00000004949; -.
DR Ensembl; ENSGACT00000004963.1; ENSGACP00000004949.1; ENSGACG00000003767.1.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT01020000230394; -.
DR InParanoid; G3NHY9; -.
DR OMA; TPYFYET; -.
DR TreeFam; TF312962; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000003767; Expressed in embryo and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd12793; RasGAP_plexin_B1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF59; PLEXIN-B1 ISOFORM X1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 2.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1477..1497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..448
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 48..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1257..1286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..821
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2123 AA; 234261 MW; 70A2A52C3E9A0AC8 CRC64;
FSRNDTEFQH LVLHPDPSLG TVYVGARDHL FQLDGADGLR LELEEKTGPV SDSKDCLPPV
TESNCPQARR TSNHNKLLLV DPKALELITC GSIHQGTCQK RSLASIQAVR FSTERPVDTQ
YVAANDPLVS TVGLVVGLRG ERTVMYVGRG YTASHPPIST RHLSVEPIFS YEETAKLAVA
GRLSEYDHHF VKAFTRRSYV YFLFYRRDIK SPSREYRTYA ARVCLDDTSY YSYVEVPLVC
RSASSPSRTY NLLQAAQVGQ GVDREGEDLL GVFSSRVGPT NNAALDASAL CVYPLDELDG
HIDSTRNLCY TQDGRVEGRG EVAYIEYDVK SSCANLPMNT LKAYPCGSDH TPSPMASRAP
LEARAAWHTS AARLTAVAVS VRDGHSIAFL GDSRGTLHKV YLGQDGQAEV YANTTIQLNS
PINGDLLLDR TGAHIYVMTR TTVKKLPVAE CGDHLDCQSC LSANDPYCGW CVLEGRCGQR
RECQRGSVQG QWLWSFNRTQ QCLSIQRLSL YNISRGEKTD ITVSVEGLPG LGEGEAYSCF
FQDTEATASL TNAGVICSTP DAGSLPPIRH GDEFVMVALS LRFTNVTVAE TEFTFYNCSS
VQQLSGRRPC QGCVSSRWGC SWCIHQHVCT HKRTCSRGVT VYNRNFKPPT PTVPPPARNL
NPLPTVRAAA TTTTQPSPTE PLPPTTAAVP LTSTAVAPPT SPLTLASTSP SVVIFTQAPT
THTDVPTTSE GATDGNGGIA SFSEDEEAES LNITAKYSAT ALPSSTTQKV DHDVGFLDPS
AEAFGSSFDV SPTDSRGESR LIDLSVSGTK DPEEKDSPRW FSEWEGTAGD SATGPSVVGA
SEKPPISQAP ETVINPLFES AADYQLDSST HSFFPVSAGA LRASECPCVE KVRDSALLPV
NVERKVTLLG QHLNLFQDEI LDYECVLDVE NESVVMEALV EADATYPSAF FITCQAHQYS
YAASLEEYLA AINVRRKNSF LIDSAEDLHV TLFNCSVGRS DCSRCRTADP KYGCVWCAGV
SGSRCVYRDS CAEEVKHTCP APVIHYLDPV SGPVEGGTVV TISGSNLGQR AVDIQQSVLV
AGVPCSVIHS RYEVSSRIVC ETTSSGREKS GQASVRVSGG GLGLSAQIFS FQDPVLSGVF
PQRGPKAGGS SLTIRGRRLR TGHPSEVGVL IGGVPCVVLN IQEDQINCLT RGSNRTGEHG
ITVRFGSTER HLQGLVYHYT PNPNISKAAP SKSFLSGGRI IRVSGQNLDV VQEPKMRVTF
SPPDTLPPRR KRSKRRSEGR DRPGPVKRWR RIVPEAECPE GTLCHVKQFE SRCTVNGSTL
ILCPTPAVGP QARRARVKVH FLLDSLHFDF RSVGSEDFSY EPNPQLYLLN QNDPSKPYHH
KPGSIISVEG ENLDLAIYKQ EVEARIGAGL CSVKTLTHNH LYCEPPAQQP SVTAGKRQEG
LDSLPEFTVR MGNLNFSLGR VQYDRQAQST FPLEAQVGVG VGASIVALIV LMIVLIYRRK
SKQAMRDYKK VQIQLENLET SVRDRCKKEF TDLMTEMMDM SSDLVGSGIP ILDYRAYAER
IFFPGHQESP LRRDLDVPES RRQTVEQGLV QLSNLLNSKL FLTKFIHTLE VQRTFSPRDR
AYVASLLTVA LHGKLEYFTD ILKTLLNDLV EQYVAKNPKL MLRRTESVVE KLLTNWMSIC
LFTFLRESAG ESFYMLFRAI KHQVDKGPVD AVTGKAKYTL NDNRLLREDV EYRTLTLNVA
TAAAATSGGT TTQTVPAKVL DCDTITQVKE KLLEQTWKGT SFSLRPHVDS LHLEWRAGVA
GHLILSDEDL TSVVQGSWKR LNTLQHYKVP DGATVALVPR NTKNHLHDSH DYMPGEKTPM
LDDGEEGGVR LWHLVKAGEE SELPNHRRGS VRERGGERAK AIPEIYLTRL LSMKGTLQKF
VDDLFTAILS TSRPVPLAVK YFFDLLDEQA LQHNITDPET IHIWKTNSLP LRFWINILKN
PQFIFDVQTS DHVDAVLSVI AQTFMDSCTI ADHKLGRDSP INKLLYARDI PRYKQMVERY
YADIRQTISA SDQEMNSALA ELSRNYAAEV NSLVALHELY KYINKYYDQI ITALEEDATA
QKMQLGYRLQ QIAAAVENKV TDL
//
