ID   G3NKQ6_GASAC            Unreviewed;       459 AA.
AC   G3NKQ6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=allantoinase {ECO:0000256|ARBA:ARBA00012863};
DE            EC=3.5.2.5 {ECO:0000256|ARBA:ARBA00012863};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000005919.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000005919.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000005919.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation; allantoate
CC       from (S)-allantoin: step 1/1. {ECO:0000256|ARBA:ARBA00004968}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Allantoinase family. {ECO:0000256|ARBA:ARBA00010368}.
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DR   AlphaFoldDB; G3NKQ6; -.
DR   Ensembl; ENSGACT00000005936.1; ENSGACP00000005919.1; ENSGACG00000004463.1.
DR   GeneTree; ENSGT01030000234527; -.
DR   UniPathway; UPA00395; UER00653.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000004463; Expressed in liver and 6 other cell types or tissues.
DR   GO; GO:0004038; F:allantoinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050897; F:cobalt ion binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000256; P:allantoin catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR017593; Allantoinase.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR03178; allantoinase; 1.
DR   PANTHER; PTHR43668; ALLANTOINASE; 1.
DR   PANTHER; PTHR43668:SF2; ALLANTOINASE; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; Composite domain of metallo-dependent hydrolases; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT   DOMAIN          54..433
FT                   /note="Amidohydrolase-related"
FT                   /evidence="ECO:0000259|Pfam:PF01979"
SQ   SEQUENCE   459 AA;  49980 MW;  24E9F017C002C50F CRC64;
     MEPGSSVGAV RSKRVLLGDQ VRPAVIVIKD GTIHQILSDS DFPGGEVLDV GDSVVMPGIV
     DCHVHVNEPG RVSWEGFWTA TRAAAAGGVT TIVDMPLNSI PPTTTVGNFH EKQLEATGKC
     FVDTAFWGGV IPGNQLELRP MIQAGVAGFK CFLIHSGVEE FPHVTEQDLH AAMAQLQGTG
     SVLLFHAEVD VQQTTQENGA LDPRQYSTFL QSRPDIMEME AIRTITALCL QYQVRCHIVH
     LSSAKPLELI REARQAGAPL TVETTHHYLS LCAEDIPAGA TQFKCCPPIR GSVNQEQLWS
     ALKAGQIDMV VSDHSPCTPD LKKLDNGDFT EAWGGISSLQ FGLPLFWSSA SKRGFQLSDV
     ARLLSQQTAR LGSLDNRKGS LAPGYDADLV VWDPEKEFEI KEASIHHKNK LTPYLGLTLR
     GVVCATIVRG QLVYREGSFC PEPLGKHLLV PPRENQVQL
//