ID G3NL90_GASAC Unreviewed; 369 AA.
AC G3NL90;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Actin-related protein 2/3 complex subunit {ECO:0000256|PIRNR:PIRNR038093};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000006103.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000006103.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000006103.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions as component of the Arp2/3 complex which is
CC involved in regulation of actin polymerization and together with an
CC activating nucleation-promoting factor (NPF) mediates the formation of
CC branched actin networks. {ECO:0000256|PIRNR:PIRNR038093}.
CC -!- SIMILARITY: Belongs to the WD repeat ARPC1 family.
CC {ECO:0000256|ARBA:ARBA00006260, ECO:0000256|PIRNR:PIRNR038093}.
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DR AlphaFoldDB; G3NL90; -.
DR Ensembl; ENSGACT00000006120.1; ENSGACP00000006103.1; ENSGACG00000004610.1.
DR GeneTree; ENSGT00950000183183; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000004610; Expressed in zone of skin and 7 other cell types or tissues.
DR GO; GO:0005885; C:Arp2/3 protein complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR017383; ARPC1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10709; ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1; 1.
DR PANTHER; PTHR10709:SF17; ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT; 1.
DR Pfam; PF00400; WD40; 3.
DR PIRSF; PIRSF038093; ARP2/3_su1; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR038093}; Cytoplasm {ECO:0000256|PIRNR:PIRNR038093};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR038093};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 51..87
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 369 AA; 40916 MW; C6FE4776EB0FACD7 CRC64;
CSDMSLYSFG LEPLSCHTWN KDRTQIAVSH NNNVVNIYEK KGKEWVKTHE LTEHSGRVTG
IDWAPESNRI VTCASDRNAY VWTLKDGVWK PTLVLVRINR AATCVKWSPL ENKFALGSGA
RLISVCYFEK ENDWWLSKHI KKAIRSTVMS LDWHPNNVLL AAGSADFHCR VFSAYIKDIE
DKPGPTAWGA KMPFGEVLLE HKDCGGWVHS VAFSPSGDQL ACVAHNSSIT VVDAAQGKEV
TQLTTDRLPL LSVLYVNATE LVAAGHDCCP YQFTYKGPGA VEFVKKLDIP KQTSKGGISA
MQHFQNLDKR ATDEDSNELG TLHQNSITQL CVVSGERAKV QKYSSVGLDG AMVIWDFKAN
GKKELTLEA
//
