ID G3NMG2_GASAC Unreviewed; 464 AA.
AC G3NMG2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Tubulointerstitial nephritis antigen like 1 {ECO:0000313|Ensembl:ENSGACP00000006525.1};
GN Name=TINAGL1 {ECO:0000313|Ensembl:ENSGACP00000006525.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000006525.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000006525.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000006525.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR AlphaFoldDB; G3NMG2; -.
DR STRING; 69293.ENSGACP00000006525; -.
DR Ensembl; ENSGACT00000006542.1; ENSGACP00000006525.1; ENSGACG00000004892.1.
DR eggNOG; KOG1544; Eukaryota.
DR GeneTree; ENSGT00940000160023; -.
DR InParanoid; G3NMG2; -.
DR OMA; AEIYHSG; -.
DR TreeFam; TF313765; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000004892; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02620; Peptidase_C1A_CathepsinB; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR036201; Pacifastin_dom_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF834; SI:DKEY-158B13.1; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF57283; PMP inhibitors; 1.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..464
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018675355"
FT DOMAIN 49..97
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
SQ SEQUENCE 464 AA; 52696 MW; 4EA25D609992AA8F CRC64;
LFLLSVAALL LVMGETNAER ILSRRTKRDL ANPLHVRGIR DPFGSYCERR GGCCPGRDDL
CTVPYLDTIC YCDLFCNRTI ADCCPDFWGH CLGVEPPFID TCERNGNKFF TGQTYKENCN
LCTCGITGRW ECEQNACLME PGLIDGVNRG NYGWTAANYT QLYGMTLDEG IRFRLGTQRP
SRTVMNMNEM QMNMDPESDS LPLYFNSAEK WPGKIHEPLD QGNCAASWAF STAAVASDRI
SIQSMGHMTP QLSPQNLISC DTRNQGGCEG GRVDGAWWYL RRRGVVTEGC YPYRPPQETP
AEVGRCMMQS RSVGRGKRQA TQRCPNAHNY QNDIYQSTPP YRLSSNEKEI MKEIMDNGPV
QAIMEVHEDF FVYKNGIYKH TDVSFTKPPQ YRKHGTHSIR ITGWGEERSF DGTSKKYWIA
ANSWGKNWGE NGYFRIARGE NECEVETFVI GAWGRITMED MHSH
//
