ID G3NMY4_GASAC Unreviewed; 635 AA.
AC G3NMY4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=RAD17 checkpoint clamp loader component {ECO:0000313|Ensembl:ENSGACP00000006697.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000006697.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000006697.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000006697.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the rad17/RAD24 family.
CC {ECO:0000256|ARBA:ARBA00006168}.
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DR AlphaFoldDB; G3NMY4; -.
DR STRING; 69293.ENSGACP00000006697; -.
DR Ensembl; ENSGACT00000006714.1; ENSGACP00000006697.1; ENSGACG00000005069.1.
DR eggNOG; KOG1970; Eukaryota.
DR GeneTree; ENSGT00440000039046; -.
DR InParanoid; G3NMY4; -.
DR OMA; YNCLKMA; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000005069; Expressed in diencephalon and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031389; C:Rad17 RFC-like complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0000077; P:DNA damage checkpoint signaling; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR004582; Checkpoint_prot_Rad17_Rad24.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR018324; Rad17/Rad24_fun/met.
DR NCBIfam; TIGR00602; rad24; 1.
DR PANTHER; PTHR12172; CELL CYCLE CHECKPOINT PROTEIN RAD17; 1.
DR PANTHER; PTHR12172:SF0; CELL CYCLE CHECKPOINT PROTEIN RAD17; 1.
DR Pfam; PF03215; Rad17; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 116..266
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 25..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 635 AA; 71021 MW; 7FFBF1C455E1F548 CRC64;
MENLSEGERA APSRLNRWVD QSFADLPGES FAPPRQKKGC RALPSKAESK KPRKRTGESR
SSDAPASQLL KESAPGEQDE PWVDRYTPRS QVELAVHKKK IEEVENWLRV HLNAHKGGVL
LLTGPSGCGK TATVRVLSLE LGLRVQEWTN PSNLEPYGSG QHADWRTNGS SCSSQLVQFQ
DFLLRANKYN CLQMVGDGEA TERKLILVED FPNLFYRQPG GLHDILRRFV KTGRCPLVCV
VSDSLSGDSS SRFLFPREIQ EELNISNISF NPVAPTTMIK VLSRISAAEA GKSCGRMCVT
DPAVLETLCS GSSGDIRSAI NSLQFSSLPD TSLEAGMWRL KKDRHGTSLS KAVSRTNQRR
KKSKLTKEHK EEQPIGGKDA SLFLFRALGK ILHCKRESYR RVSRAGLPAH LAHHHREALL
VEPESVVERS HMSGEFFNLY LHQNYLDFFS EVEDVDRASE YLSDADLLTS DWASRSTMGQ
YGSSVATRGL LHSNSQQVSV GFRPLHKPNW LLVNKKHREN CLAAQSLFRS FCLTPVSLQT
ELLPYLAKLT NPMRNQAQIA FIQDVGQMSL RRFPGRLKLE ALTDKEPALL DKDSEDEEDS
KCGVEEGLSA SQPQPTTTQV LLEEEEVMIE DYNSD
//
