ID G3NPD2_GASAC Unreviewed; 942 AA.
AC G3NPD2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Toll-like receptor 22 {ECO:0000313|Ensembl:ENSGACP00000007196.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000007196.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000007196.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000007196.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; G3NPD2; -.
DR Ensembl; ENSGACT00000007214.1; ENSGACP00000007196.1; ENSGACG00000005449.1.
DR GeneTree; ENSGT00940000163999; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000005449; Expressed in spleen and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF551; LOW QUALITY PROTEIN: TOLL-LIKE RECEPTOR 13-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 17.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 759..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 782..923
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 942 AA; 107400 MW; C0E2499F81F2788E CRC64;
RECLCFCTLN VSSSALPVRG FYLKSGRITD FNASCSRLHL QAVPRDIPST VRGFDLSENR
ITMIQAPDFK NFSALITLDL KRNMISQIDA GAFADLISLK TLNLNNNRLT AVGDDLFHGL
SNLTELRINN NRIKNLSSTS FESLTSLTFL DMSYNRLHLL TKVHTMLQQL PNLLELSVKS
NLITSFHSWD LTNRSLKLTS LDLSLNDITV FKVTADVFPN LTSLSIGRIH SKRTAMQWDI
RGGTFFSRVS TLDISGLKMD EAAMRPLGEN FNPSLTSLRM NAMRGTRLTK LVNVSCSVPT
VSRLQMQQNN LHYINAKFFQ LCANITEMDL GKNSIANISY EAFRSLPGLK ILNLSQNKLA
FITPATGNLP TLEELDLSQN YITTLGCNSF ANLTKLKILS LHQNSIPALR KCVFEGLIKL
QVVKLQNNSI SKLDGAFSIH LPNLKRLRLN INKLTAIKRG DFAGLQSLES LALDNNMITT
LEHGSFKGLS NLTELQLSTN RIDETTLPER FRDLVNLESL DLSENRVQFK NAFLTPPPFS
GLSRLRTLVF LGNGRRGKFS LPYNLLEGLT NLSFFSARKN QLSFLHRDTF NYTPRLQTLD
IGANDLRNLS SELFHPIGGL ESLYISKISL DSLDFLIDAN LTKLEFIQGK LNQYSVLSEE
VIKSMPSLVY LNLQGNSFTC DCDNAYFRSW IVNDKQTQVY EADKFLCNYP SELKGKKLLE
LDVKSCTVNT EFIYFISTTS TILLFMLTSL TYHFMRWQLV YAYYLFLALL FDTKLKNKQQ
PKRYDAFVSY NTSDEPWVMR QLLPKLEGEQ GWRLCLHHRD FEPGKPIIDN ITDAIYGSRK
TICVISRRYL ESEWCSTEIQ VASFRLFDER KDVLVLVFLE DIPGAELSPY YRMRKLLKRR
TYLSWPRAGQ HPNLFWEKLR QALGTKDDPG REELVPTLLD RQ
//
