ID   G3NPE0_GASAC            Unreviewed;       443 AA.
AC   G3NPE0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=Battenin {ECO:0000256|RuleBase:RU361113};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000007204.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000007204.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000007204.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane
CC       {ECO:0000256|RuleBase:RU361113}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361113}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the battenin family.
CC       {ECO:0000256|ARBA:ARBA00007467, ECO:0000256|RuleBase:RU361113}.
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DR   AlphaFoldDB; G3NPE0; -.
DR   STRING; 69293.ENSGACP00000007204; -.
DR   Ensembl; ENSGACT00000007222.1; ENSGACP00000007204.1; ENSGACG00000005447.1.
DR   eggNOG; KOG3880; Eukaryota.
DR   GeneTree; ENSGT00390000003249; -.
DR   InParanoid; G3NPE0; -.
DR   TreeFam; TF314055; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000005447; Expressed in spleen and 13 other cell types or tissues.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR   GO; GO:0007040; P:lysosome organization; IEA:Ensembl.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR003492; Battenin_disease_Cln3.
DR   InterPro; IPR018460; Battenin_disease_Cln3_subgr.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR10981; BATTENIN; 1.
DR   PANTHER; PTHR10981:SF0; BATTENIN; 1.
DR   Pfam; PF02487; CLN3; 1.
DR   PIRSF; PIRSF015974; CLN3_BTN1; 1.
DR   PRINTS; PR01315; BATTENIN.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Lysosome {ECO:0000256|RuleBase:RU361113};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361113};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361113};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361113}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        31..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361113"
FT   TRANSMEM        107..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361113"
FT   TRANSMEM        131..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361113"
FT   TRANSMEM        164..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361113"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361113"
FT   TRANSMEM        283..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361113"
FT   TRANSMEM        350..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361113"
FT   TRANSMEM        377..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361113"
FT   TRANSMEM        413..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361113"
SQ   SEQUENCE   443 AA;  48730 MW;  23F7DF0997450D9F CRC64;
     MEREEPPREE PAPRADSSGA AAAQWRNWSG FWLLGLCNNF AYVVMLSAAH DILNQQESRN
     TPDPPNQTRY FTFQCHVFAD EAVLLADILP TLAIKLSAPF VIHKLPYGFR VLFCAFMAAG
     SFLLVSFSSA VWMSILGVIF ASVGAGLGEL TFLSLTVYFS RDVLGGWGSG TGGAGVGGAL
     LYSGLTQAGL SPQVTLLSML VVPVVMCLSY FFLLDLPPSL PQWRCAETEY RAVGSEDRRA
     LMDGSEEEEQ EKSTPAILGE LCHKLAAGAP VSQHRRPLNH ISLSLGLLWF VLPLGLVYFA
     EYFINQGLME LLYFPKLFLS HAQQYRWYQT LYQVGVLVSR SSLCCVKIRN LWTLSLLQVV
     NAVLLLLAVR FQFLPSAWVV FAIVLYEGLL GGAAYVNTFY FISKETGDRH REFAMAAASV
     GDSLGIAAAG LAAFPVHRYF CSL
//