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Database: UniProt
Entry: G3NQL0_GASAC
LinkDB: G3NQL0_GASAC
Original site: G3NQL0_GASAC 
ID   G3NQL0_GASAC            Unreviewed;      1176 AA.
AC   G3NQL0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-DEC-2019, entry version 54.
DE   SubName: Full=Thrombospondin 2a {ECO:0000313|Ensembl:ENSGACP00000007626};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000007626, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000007626}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000007626}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   STRING; 69293.ENSGACP00000007626; -.
DR   Ensembl; ENSGACT00000007645; ENSGACP00000007626; ENSGACG00000005771.
DR   eggNOG; ENOG410IFQQ; Eukaryota.
DR   eggNOG; ENOG410XQKE; LUCA.
DR   GeneTree; ENSGT00940000157846; -.
DR   InParanoid; G3NQL0; -.
DR   OMA; IQTRMCS; -.
DR   TreeFam; TF324917; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR   Gene3D; 2.20.100.10; -; 3.
DR   Gene3D; 4.10.1080.10; -; 2.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR024731; EGF_dom.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR003367; Thrombospondin_3-like_rpt.
DR   InterPro; IPR017897; Thrombospondin_3_rpt.
DR   InterPro; IPR008859; Thrombospondin_C.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR015455; TSP2.
DR   InterPro; IPR028974; TSP_type-3_rpt.
DR   InterPro; IPR001007; VWF_dom.
DR   PANTHER; PTHR10199:SF10; PTHR10199:SF10; 1.
DR   Pfam; PF12947; EGF_3; 1.
DR   Pfam; PF00090; TSP_1; 3.
DR   Pfam; PF02412; TSP_3; 7.
DR   Pfam; PF05735; TSP_C; 1.
DR   Pfam; PF00093; VWC; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00209; TSP1; 3.
DR   SMART; SM00210; TSPN; 1.
DR   SMART; SM00214; VWC; 1.
DR   SUPFAM; SSF103647; SSF103647; 3.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82895; SSF82895; 3.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS50092; TSP1; 3.
DR   PROSITE; PS51234; TSP3; 8.
DR   PROSITE; PS51236; TSP_CTER; 1.
DR   PROSITE; PS01208; VWFC_1; 1.
DR   PROSITE; PS50184; VWFC_2; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00634};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Repeat {ECO:0000256|SAAS:SAAS00814929}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..1176
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003448652"
FT   DOMAIN          323..380
FT                   /note="VWFC"
FT                   /evidence="ECO:0000259|PROSITE:PS50184"
FT   DOMAIN          553..593
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          652..696
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   REPEAT          697..732
FT                   /note="TSP type-3"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT   REPEAT          733..768
FT                   /note="TSP type-3"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT   REPEAT          769..791
FT                   /note="TSP type-3"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT   REPEAT          792..827
FT                   /note="TSP type-3"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT   REPEAT          828..850
FT                   /note="TSP type-3"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT   REPEAT          851..888
FT                   /note="TSP type-3"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT   REPEAT          889..924
FT                   /note="TSP type-3"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT   REPEAT          925..960
FT                   /note="TSP type-3"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT   DOMAIN          964..1176
FT                   /note="TSP C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51236"
FT   REGION          850..933
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1176 AA;  130862 MW;  D4ED28CFAE6A9690 CRC64;
     MILRRSLFLL LLSSTFLHAL PQDDEQEDET SFDLFEISHI TRKTLGAKQF RGQNSDAPAY
     RFIRFDHLPP VSPPILKQIL RQIQNNEGFV FVASMRQDRT SRGTLIGLEA PDGRRQFEIV
     SNGRANTLDL VYWVDGSQNV VSFEEVDLSD SQWKNITLHV HGENANLFVG CSLIDSFILD
     EPFYEHLKAE GNRMYVAKGS TRENHFRGLL QNVRFVFDTP VEDVLLSRDC EVPKQEYVNI
     VSESTEIMDV SPSITTNIIG QQTDNPAADM CERSCEELST MFQELKGLRV VVSNLIDGLQ
     KVTEENTLMK EALGRMKNTK EKNMCWQDGR LFDDKEDWVV DSCTKCTCQE SKIVCHQITC
     PPVACAIPSF IDGECCPVCM PTDSEDGWSP WSEWTECTVT CGTGTQQRGR SCDATSNPCT
     GPSIQTRKCS LGKCDSRVRQ DGGWSLWSPW SSCSVTCGEG QITRIRHCNA PVPQLGGKDC
     EGSGRETQRC TAKPCPVDGS WGPWSPWATC SATCGGGVKS RARVCNSPQP QYGGKNCNGE
     AKDSDVCNIK DCPLDGCLSN PCFGGVECNS SPDGSWECGP CPTGFRGNGT NCEDINECDM
     VSDVCYKVSG MQRCINTDPG FHCLPCPKRY KGTQPFAVGV EAAKKNKQVC EPENPCKDNT
     HNCHKYAECI YISHFSDPMY KCECRTGYAG DGFFCGEDSD LDGWPNQNLV CGANATYHCK
     KDNCPSLPNS GQEDFDKDGQ GDACDKDDDS DGILDERDNC PLLYNPRQFD FDKDEVGDRC
     DNCPYEHNPA QIDTDHNGEG DACAVDIDGD DIMNESDNCP YVYNTDQKDT DMDGVGDHCD
     NCPLLHNPDQ TDVDNDLVGD QCDNNQDIDE DGHQNNQDNC PYVANANQAD HDKDGKGDAC
     DYDDDDDGIP DDKDNCRLTP NADQIDSDAD GRGDACKDDF DNDNIPDILD VCPENDAISV
     TDFRKFQMVH LDPKGTTQID PNWVVRHQGK ELVQTANSDP GIAVGFDEFS AVDFSGTMYV
     NTDRDDDYAG FVFGYQSSGR FYVVMWKQIT QTYWEDKPSK AFGISGVSLK VVNSTTGSGE
     NLRNALWHTG NTPGQVRTLW HDPKNIGWKD YTAYRWHLIH RPKTGFIRVV VYEGKLIMAD
     SGPIYDKTFA GGRLGLFVFS QELVFFSDLK YECRAK
//
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