ID G3NRD3_GASAC Unreviewed; 640 AA.
AC G3NRD3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Choline dehydrogenase {ECO:0000256|RuleBase:RU003969};
DE EC=1.1.99.1 {ECO:0000256|RuleBase:RU003969};
GN Name=CHDH {ECO:0000313|Ensembl:ENSGACP00000007900.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000007900.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000007900.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000007900.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=A + choline = AH2 + betaine aldehyde; Xref=Rhea:RHEA:17433,
CC ChEBI:CHEBI:13193, ChEBI:CHEBI:15354, ChEBI:CHEBI:15710,
CC ChEBI:CHEBI:17499; EC=1.1.99.1;
CC Evidence={ECO:0000256|RuleBase:RU003969};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC choline pathway; betaine aldehyde from choline (cytochrome c reductase
CC route): step 1/1. {ECO:0000256|RuleBase:RU003969}.
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|RuleBase:RU003968}.
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DR AlphaFoldDB; G3NRD3; -.
DR STRING; 69293.ENSGACP00000007900; -.
DR Ensembl; ENSGACT00000007919.1; ENSGACP00000007900.1; ENSGACG00000005956.1.
DR eggNOG; KOG1238; Eukaryota.
DR GeneTree; ENSGT00530000063260; -.
DR InParanoid; G3NRD3; -.
DR OMA; NHFESCA; -.
DR TreeFam; TF313911; -.
DR UniPathway; UPA00529; UER00385.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000005956; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0008812; F:choline dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR011533; BetA.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR NCBIfam; TIGR01810; betA; 1.
DR PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00623; GMC_OXRED_1; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU003968};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 164..187
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00623"
FT DOMAIN 336..350
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT BINDING 166
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 174..177
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 640 AA; 71000 MW; 84C624BAE59D64BF CRC64;
MLSLVTSGQT AARRIVTATR GTLVRGGGCL LTHLPESALR TKNTGRSFSQ SVFNHYRCFS
ATAANWRASS PAANHNTPSY SYVIVGAGSA GCVLANRLSE DSHESVLLLE AGPKDMLLGN
PQLSWKIHMP AALIYNLCDD KYNWYYHTLP QAHMGERVMY WPRGRVWGGS SSLNAMVYIR
GHAEDYNRWQ REGAEGWDYE HCLPYFRKAQ CHEQGENRYR GGSGPLHVSR GKTNHPLHRA
FIEAGQQAGY PFTDDMNGLQ QEGLGWMDMT IYKGKRWSTA SAYLRPVLGR PNLKAEVRCL
TTKILFDGKR AVGVEYTQKG QTKRVFADKE VIISGGAINS PQLLMLSGVG NADDLKPLGV
SVVQHLPGVG SNLQDHLELY IQHQCTQPIT LYKAQKPFHM VKIGLEWLTR FTGYGASSHL
ESGGFIRSRP HVPHPDIQFH FLPSQVIDHG RVASKIEAYQ VHVGPMRSTS KGWLKLKSAN
PLDHPILQPN YLSTDVDVWE FRESVKLSRE IFTQKAFDPF RGPEVLPGPH VQSDAEIDAF
VREKADSAYH PSCTCKMGSP SDPLAVVDSS ARVLGLENLR VVDASIMPSI VSGNLNAPTI
MMAEKAADII RSRPALVDPG VPVYRPPTLD TQRPRGKIMK
//