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Database: UniProt
Entry: G3NRS0_GASAC
LinkDB: G3NRS0_GASAC
Original site: G3NRS0_GASAC 
ID   G3NRS0_GASAC            Unreviewed;      4836 AA.
AC   G3NRS0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-DEC-2018, entry version 49.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSGACP00000008037};
GN   Name=RYR3 (1 of many) {ECO:0000313|Ensembl:ENSGACP00000008037};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000008037, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000008037}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000008037}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   STRING; 69293.ENSGACP00000008037; -.
DR   Ensembl; ENSGACT00000008056; ENSGACP00000008037; ENSGACG00000006040.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000155507; -.
DR   InParanoid; G3NRS0; -.
DR   OMA; PLLNEYC; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007635};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4151   4170       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4377   4397       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4447   4471       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4637   4658       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4713   4736       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      213    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    330       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      338    395       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      597    796       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1012   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1254   1460       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     3586   3606       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4836 AA;  546309 MW;  C47E58B12A908F67 CRC64;
     QSQGALAEDT LRFTIQDDEV VLQCVACIQK ENRKFCLAAE GLGNRLCYLE PTSEAKYVPP
     DLCICTFVLE QSLSVRALQE MLAKSGQNSE GAAQSGGHKT LLYGHAILLR HSFSSMFLAC
     LKTSRSQTDK LSFDVGLQED STGEACWWTI HPASKQRSEG EKVRIGDDLI LVSVSSERYL
     HLSISSGNIQ VDASFMQTLW NVHPICSGSN IEEGYLLGGH VMRLFHGHDE VVAIPGSDQT
     EEQQRIVNYE TGKAGAKARS LWRLEPLRIS WSGSHIRWGQ AFRLRHLTTG HYLALSDDRG
     LVLQDRERSD TVATAFCFRA SKEKLEQSPK RDIDGMGAAE IKYGDSLCFI THVATGLWLS
     YQAPDVKSAR LGPLKRRACL HSEGHMDDGL TLQRCQHEES RAARIIRNTT LLFKRFIRDL
     DCLGMKNWAL VTLPVEEVLQ TLNDLITYFQ LPDAELEHEE RQIKLRSLKN RQNLFKQEGM
     LTLVSNCIDR LNVYNSAAHF GECAGSEAGI AWKDILNLLY ELLAALIRGN RNNCTQFSNN
     LDWLVSKLER LESSSGILEV LHCILTESPE ALNIIQRGHI KSIISLLYKH GRNHKILDVL
     CSLCVCNGVA VRTNQNLICD HLLPRRDLLL QTQLVNDVQS MRPNIFLGVS EGSAQYKKWY
     YELMIDQVDH FVTSEPSHLR VGWANAKGYA PYPGGGEGWG GNGVGDDLYS YGFDGLHLWS
     AGRIPRAVAS VNQHVLTSED VVSCCLDLGA PSISFRINGQ PVQGMFENFN TDGLFFPVVS
     FSAGVKVRFL LGGRHGDFKF LPPSSYAPCY EALLPKEKMK VEPVKEYKRD VDGVRDLLGT
     TRLTSQASYI PTPVETSQIG MLPHLEKVRD KLAENIHELW GMNKIELGWM YGKIRDDNKR
     QHPCLVDFSK LPETEKNYNL QMSTETLKTL LALGCRVGQV NPNAESSLKK IKLPKNYMMS
     NGYKPFPLDL SDIKLTPGQE LLVDKLAENA HNVWAKDRIK QGWTYGIQQD VKSKRNPRLV
     PYALLDERTK KSNRDSLREA IRTLIGYGYN IEPSDQEGVG QVAERLSIDK IRFFRVERTY
     AVKSGKWYFE FEAVTGGDMR VGWARPGCKP DLELGTDGLA FVFDGYRGHC LNMGSRLFGR
     CWRAGDVVGC MINMEDKSMI FTLNGEILIT TKGSELCFTD FETEDGFIPV CSLGLAQVGR
     MNLGKDASTF KYYTMCGLQE GFEPFAVNMN REVTMWFSKR LPTFVNVPKD HNHIAVTRID
     GTVDSPPCLK VTHKTFGSQN SNADMVFCRL SMPVEFHSVF KAGPVVDMNG VHEEDSLKTS
     KYYHSVRVFA GQDPAGVWVG WVTPDYHYYS SNFNLSKTRS VTVTLGDERG RVHESVRRSN
     CYIVWGADVT NAAHASSRSN VDLEIGCLID VATGLLTFTA HGKEIATSYQ VEPNTKLFPA
     VFVRPTSPNL FQFELPKIKN AMPLSSAIFK SEHKNPVPQC PPRLDVQTIS AVLWSRMPNT
     FLKVETARVN ERHGWVVQCA EPLQMLAVHI PEENRCVDIM ELSEQEDMKT FHYHTLKLYC
     ALCALGNTRV AHALCSHLDQ SQLLYTIDNQ YLSGMLREGF YNVLISTHLE TAKEARLTMK
     DEFIIPVTAE TRSIRLFSDA SKKHLPPGVG LSTSLKPRLN FAPPCFINTK REQHLYSPQI
     PLDALKEKSI LMLTEAVQGG GHHIRDPVGG GVEYQFVPIL KLISTLLTMG VLCSEDVHKV
     LLLVDPNVFR ETRGEGAAGA THKEGLTGAE EKAVEAGEEE AAKDGKQPMK GLLEKRLPEP
     VKRQMCELLH YFCDCELKHR IEAIASFSDT FVSKLQYNQK FRYNELMLAL NMSAAVTAKK
     TKEFRSPPQE QINMLLTFSV GEDCPCPADI QEELYDFHNQ LQLHCGIPME EDEYEQDTSI
     KGRLLMLVNK IKGQSHKAEE PAEKEQAAPS NLKELISQTM VSWAQECHVL DSELVRKMFS
     LLRRQYDSIG ELLRAMRKTY TISAASVQDT INLLAALGQI RSLLSVRMGK EEEKLMIDGL
     GDIMNNKVFY QHPNLMRILG MHETVMEVMV NVLGGHKSQE IAFPKMVASC CRFLCYFCRI
     SRQNQKAMFD HLSYLLENSS VGLASPAMRG STPLDVAASS VMDNNGLALA LEEPDLDKVV
     TYLAGCGLQS CPILLAKGYP DIGWNPIEGE RYLSFLRFAV FVNGESVEEN SSVVVKLLIR
     RPECFGPALR GEGGNGLLSA MKEAIKISET PALDLAGSVH GVSSDASADA DEEEEVVHMG
     NAIMSFYSAL IDLLGRCAPE MHLINKGKGE ALRIRAILRS LVPTEDLVGI ISIPLKMPIT
     NKDGSVTEPD MSACFCPDHK APMVLFLDRV YGIEDQSFLL HLLEVGFLPD LRAATSLDTE
     GLCTTETALA MNRFIGSAML PLLTRCAPLF AGTEHYAALV DSTLHTIYRL SKGRSLTKAQ
     RDAIEECLLA VCKHLRPSML QQLLRRLVFD VPLLTEYCKM PLRLLTNHYE QNWKYYCLPS
     GWGSYGTASE DELLLTKKIF WGVFDSLSQR KYDAELFKMA MPCLSAIAGA LPPDYVDASA
     ATTAEKPVSV DAQGNFDPRP NSTANFALPE KLEHFANKYG EHAHDKWSAE KVLLGWKYGD
     SVDEKAKIHP QLRVYKALTE KEKEIYRWPI RESLKSMLAM GWSIDRTKDG ESMSLQRENE
     KTRKISQASQ ANGFNPSPID TSHVVLSREL QGMVEALAEN YHNIWAKKKK SDLGSRGGGT
     HPLLVPYDTL TGKEKARDRE KAADLFRFLQ INGYSITRGL KDLEQDSSSM EKRFAYKFLK
     KLLKYVDSAQ EFIAHLEAMA ASGKTDRSPH EQEIKFFAKV LLPLIDQYFK NHSLYFLSSP
     SKNLSSSGYA SNKEKEMVTG LFCKLAALVR HRISLFGSDS TTIVSCLHIL AHTLDTRTVM
     KSGSEPVRLG LRTFFENAAE DLEKTFENLK LGKFTHSRSQ MKGVSQNINY TTVALLPILT
     ALFEHITQHH FGVDLLLDDV QVSCYRILTS LYALGTGKNI YVERQLPALG QCLATLAGAI
     PVAFLEPRLN PYNPCSVFST KNARERAVLG IPDSVEEMCP GMPRLDGLMK DINDMAESGA
     RYTEMPHVIE VVLPMLCNYL SYWWERGPEN VCCTTVTSEN LSLILGNILK ILNSNLGIDE
     ASWMKRIAVY VQPIISKALA DLLKSHFLPT LEKLKKKTVK VVSEEELLKA DSKGDTQEAE
     LLILDEFAVL CRDLYAFYPM LIRYVDNNRA RWLKEPDADS NELFRMVAEI FILWCKSHNF
     KREEQNFVVQ NEINNLSFLT GDNKTKMSKS FKEKSGGQDQ ERKHKKRRGE FYSIQTSLIV
     AALKKMLPIG LNMCTPGDQE LISLAKTRYL LRDTDEEVKD HIRQNLHLRV KSEDPAVRWQ
     LNLYKDIATI SEGPPDPERV VDRIQRISAA VFNLEQVEQP LRSKKCVWQK LLSKQRKRAV
     VACFRMAPLY NLPRHRSINL FLLAYQRIWI ETEEYSFEEK LVQDLAKTQP KVEEEEEEEV
     RKQPDPLHQL ILHFSHNALT ECSSLEEDPL YIAYADMMAK SCDEGEEEEE EEKDKTFEEK
     EMEKQKMLYQ QARLHDRGAA EMVLQMISAS KGRLGAMVTF TLKLGISVLN GGNILVQQKM
     LDYLKEKRDV GFFKSLSGLM MSCSVLDLNA FERQNKAEGL GMVTEEGSIN VSERGSKVLQ
     NDEFTKDLFR FLQLLCEGHN NDFQNFLRTQ TGNTTTVNII ISTVDYLLRL QESISDFYWY
     YSGKDIIDEA GQRNFSKALA VAKQVFNSLT EYIQGPCIGN QQSLAHSRLW DAVVGFLHVF
     ANMQMKLSQD SSQIELLKEL LDLQKDMIVM MLSLLEGNVV NGTIGKQMVD TLVESSSNVE
     MILKFFDMFL KLKDLTTSDS FKEYDPESKG VISKKDFQKS MENQKQYSQS EIEFLLSCAE
     ADENDMFNYE QFVERFHEPA KDIGFNVAVL LTNLSEHMPH DARLATFLDL AESVLSYFEP
     YLGRIEIMGG AKRIERVYFE ISESSRTQWE KPQVKESKRQ FIFDVVNEGG ESEKMELFVN
     FCEDTIFEMQ LASQISEPDP VERRMFESSS AFTVACISLK KSLCHFRQLL TLKSMRRQYR
     RLRKMSVREM VRGFFSFFWV IITGLLHFVY SLVWGFFHIL WTTMFGGGLV EGAKNMKVTD
     ILGNMPDPTQ FGIHGDALEM EKMEASEASA LAEMAQMAQG EAVEADLMAE LLNIQPKKEG
     KHGAEPGLGD VSEVVVGDAP SIASAVKQKK AQLAAKNTAG NGDHKSDSEK GDSEDGEKKD
     HDKAKDEAPP PPPVEKKVPK KRLGQKKELP EVFMASFFAG LEIYQTKMLN YLARNFYNLR
     FLALFVAFAI NFILLFYKVT GDYSDDEDPW NGPGRAGGEE EEDEGALEYF VLQESTGYMA
     PTLRCLAILH TIISFLCVVG YYCLKVPLVV FKREKEIARK LEFAGLYITE QPSDDDIKGQ
     WDRLVINTPS FPNNYWDKFV KRKVIKKYGD LYGAERIAEL LGMDKSALDF NPTEETVVKE
     ASLVSWLSSI DTKYHVWKLG VVFTDNSFLY LVWYTTMSIL GHYNNFFFAA HLLDIAMGFK
     TLRTILSSVT HNGKQLVLTV GLLAVVVYLY TVVAFNFFRK FYNKSEDEDE PDMKCDDMMT
     CYLFHMYVGV RAGGGIGDEI EDPAGDPYEL YRILFDITFF FFVIVILLAI IQGLIIDAFG
     ELRDQQEQVK EDMETKCFIC GIGNDYFDTT PHGFETHTLQ EHNLANYLFF LMYLINKDET
     EHTGQESYVW KMYQERCWDF FPAGDCFRKQ YEDQLG
//
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