ID G3NS27_GASAC Unreviewed; 919 AA.
AC G3NS27;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Potassium voltage-gated channel, subfamily H (eag-related), member 4b {ECO:0000313|Ensembl:ENSGACP00000008144.1};
GN Name=KCNH4 {ECO:0000313|Ensembl:ENSGACP00000008144.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000008144.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000008144.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000008144.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: The potassium channel is probably composed of a homo- or
CC heterotetrameric complex of pore-forming alpha subunits that can
CC associate with modulating beta subunits.
CC {ECO:0000256|ARBA:ARBA00011552}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3NS27; -.
DR STRING; 69293.ENSGACP00000008144; -.
DR Ensembl; ENSGACT00000008163.1; ENSGACP00000008144.1; ENSGACG00000006152.1.
DR eggNOG; KOG0498; Eukaryota.
DR GeneTree; ENSGT00940000156363; -.
DR InParanoid; G3NS27; -.
DR OMA; KSQPTLC; -.
DR TreeFam; TF313130; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR003950; K_chnl_volt-dep_ELK.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR10217:SF630; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 4; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01465; ELKCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00086; PAC; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..90
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 93..145
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 555..655
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 139..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..731
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..790
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 919 AA; 103280 MW; AD6B9B3363E41195 CRC64;
MPVMKGLLAP QNTFLDTIAT RFDGTHSNFL LGNAQGHRGY PIVYCSDAFC ELTGFTRTEV
MQKNCSCRFL YGADTSEHVA HQMEKALEGR EEYQAEVHFY KKNGVAFWCF LDIVPIKNEK
GEMVLFLFSF KDITDTYGRG HHNSKKEAGP EDKRRRRKSS PHFVEARRRG RTMLYQLTSQ
FSRGGKRGLK AIQNVSKSMI AKPSIPEYKV AAVQKSRFIL LHYSISKALW DWLILLATFY
VAVTVPYNVS FTPYDDTVTA ARSTIVSDIV VEMLFITDII LNFRTTYVSQ SGQVVYEARS
ICIHYATTWF FVDLVAALPF DLLYAFNITV TSLVHLLKTV RLLRLLRLLQ KLDRYSQYSA
MVLTLLMSVF ALLAHWMACI WYMIGRKEIA TNDTWDIGWL HELGKRLETP YTNSTAGGPT
VRSAYIAALY FTLSSLTSVG FGNVCANTDA EKIFSICTML IGALMHALVF GNVTAIIQRM
YSRRSLYHTR MTDLKDFIRV HRLPEQIKQR MLEYFQTTWS VNNGIDANEL LHDFPDELRA
DIAMHLNKDI LQLPVFKGAS RGCLRSLSLH IKTSFCVPGE YLIRQGDALH ANYFVCSGSL
EVLKDSMVLA ILGKGDLIGS DLPGTDQVIK TNADVKALTY CDLQYINVRG LREVLELYPE
YASVFTSDIH NNLTYNLREG SQDESPQGLS RFSRSPRLPH PEAISKSVET RLPSIVETKG
DDPDDSFHLS PAARSRRNLL LPNFSSPVRR TSLGNLLGDE LRQFNALRRC RSPNLSRGVH
GQSSSPQPPS KKEHGPLKAA AASTLAQGGS EAEKKPSKLL IPTVTCFGPP DLSPRVVDGI
EDNGHAFHFN VEHSRPDASA GGSTQDSTQA NANATMLHET QEVKQIISQL NQKMSTLNQA
VSNLTKDLHH MMHLLQAHM
//
