ID G3NSH0_GASAC Unreviewed; 742 AA.
AC G3NSH0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Exostosin glycosyltransferase 1a {ECO:0000313|Ensembl:ENSGACP00000008288.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000008288.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000008288.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000008288.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC {ECO:0000256|ARBA:ARBA00010271}.
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DR AlphaFoldDB; G3NSH0; -.
DR Ensembl; ENSGACT00000008307.1; ENSGACP00000008288.1; ENSGACG00000006234.1.
DR GeneTree; ENSGT00940000155321; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000006234; Expressed in intestinal epithelial cell and 10 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050508; F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0050509; F:N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR InterPro; IPR004263; Exostosin.
DR InterPro; IPR040911; Exostosin_GT47.
DR InterPro; IPR015338; GT64.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR Pfam; PF03016; Exostosin; 1.
DR Pfam; PF09258; Glyco_transf_64; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 107..392
FT /note="Exostosin GT47"
FT /evidence="ECO:0000259|Pfam:PF03016"
FT DOMAIN 476..725
FT /note="Glycosyl transferase 64"
FT /evidence="ECO:0000259|Pfam:PF09258"
FT REGION 34..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 742 AA; 85238 MW; 6DA2EC58F74D93E8 CRC64;
MQAKKRYLTL FSAGACLILV FCFGGIQVPL ARGPGRRDDR GVAGHRPGAR WRHFPGSLQP
FRRWEQDWSD DPDEHASPRG NRDANSGLYG GKRCRMDSCF NFTLCEKNGF KVYVYPQQKG
EKMSESYQNI LSSIEGSMFY TPDPGQACLF VLSLDTLDRD QLSPQYVHNL KAKVQSLHQW
NGGRNHIIFN LYSGTWPDYT EDLGLDIGLA MLAKASISTE NFRPGFDVSI PLFSKEHPRT
GGERGYLKHN TIPPYRKYVL VFKGKRYLTG IGSDTRNALY HVHNSEDVVL LTTCKHGKDW
QKHKDARCDR DNAEYDKYDY REMLYNSTFC LVPRGRRLGS FRFLEALQAA CVPVMLSNGW
ELPFSEIIDW NTAAVIGDER LLLQIPSTVR SIHQDKILSL RHQTQFLWEA YFNSVEKIVL
TTLEIIQDRV LRHTSRSNLM WNSLPGGLFT LPQYSTYLGD FPFYYAKLGV KPYTKFTAIV
HVVSPLVSQS QPVMKLLVAV AKSQYCAQVI VVWNCDKPLP AKHRWPVTSV PVIVIEGENK
VISSRFLPYD TIPTDAVLSL DEDTVLSTTE VDFAFTVWLS FPDRIVGYPA RSHFWDGSKE
RWGYTSKWTN DYSMVLTGAA IYHKYYHYLY TTYLPASLKS MVDQMSNCED ILMNFLVSSV
SKLPPIKVTQ KKQYKETMMG QSSRASRWAD PDHFAQRQTC MNKFASWFGT MPLVHSQMRL
DPVLFKDQVS ILRKKYRDIE RL
//
