ID G3NV15_GASAC Unreviewed; 1667 AA.
AC G3NV15;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Alsin Rho guanine nucleotide exchange factor ALS2 a {ECO:0000313|Ensembl:ENSGACP00000009184.1};
GN Name=ALS2 {ECO:0000313|Ensembl:ENSGACP00000009184.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000009184.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000009184.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000009184.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 69293.ENSGACP00000009184; -.
DR Ensembl; ENSGACT00000009204.1; ENSGACP00000009184.1; ENSGACG00000006911.1.
DR eggNOG; KOG0231; Eukaryota.
DR eggNOG; KOG1426; Eukaryota.
DR GeneTree; ENSGT00940000155861; -.
DR InParanoid; G3NV15; -.
DR OMA; CIAVYMS; -.
DR TreeFam; TF331793; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000006911; Expressed in zone of skin and 6 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd13269; PH_alsin; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR46089:SF3; ALSIN; 1.
DR PANTHER; PTHR46089; ALSIN HOMOLOG; 1.
DR Pfam; PF02493; MORN; 6.
DR Pfam; PF00415; RCC1; 4.
DR Pfam; PF02204; VPS9; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00698; MORN; 5.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00626; RCC1_2; 2.
DR PROSITE; PS50012; RCC1_3; 5.
DR PROSITE; PS51205; VPS9; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT REPEAT 58..105
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 106..169
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 170..220
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 522..574
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 575..625
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 702..866
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 984..1017
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1521..1667
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 459..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1447..1467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1453..1467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1667 AA; 183689 MW; 727352684A65F8B6 CRC64;
AYSHADERAP TPPERGLLHI WQSAGPSAQL CPDRVLLSRP VLQASLGEHH GLLLTQGGQV
YSFGELLWRD LSVPVSAPLL EISLLGRTVV RVAAGGFHCG ALSEQGNVFM WGENTAGQCG
LSERGTDTSI TVSEPCPVSV VDSDVVPPAA VQVVDLALGR EHSLALSARN ELWAWGSGCQ
LGLVTNTFPV WRPQKVEHLA GRHVVQVACG AYHSLALVRS LHQQNQNASE KTQRGQSPHC
AVTEGEEPFA ADAGHYCPLG VELTEVMTHE VTTSKIQKTV LAKTRCCSNV LGSVSMSVDS
YLRIGNTPPL QETEGRPRAH PMTGWRTNKK PAFPDEAELQ NLLQKLSSHS LEMRHSAGPG
DTDSMSSYTS VTKKIHQLRV KATSDSVGQC LNNLMRQSCP CKGVFVWLFI LLKRLLFLTQ
STSTLTCGVA APYSSSVPVC LEEVRLCLAA EKRALRGPKS TSLTNINQKG KAAANRRRSL
PGTPTQGSPR QRRCSAGRPS SSCRSRSAAP EEAGGGLPSL ETEVWSWGRG SEGQLGHGDQ
LASRLQPLCI KCLTGEEVIK VAAGSHHSLA LTAHCQVYSW GSNMCGQLGH VNSPVTVPRQ
TELSDGLRVW DVSAGQSHSL LLADGDCVQP VLLYCGPRKE PSCTQTERSR NTQRSPNRAE
SYAVRPDLLP FCVEMGYISG VCSGGQSCAA LADVNVMGFI GAIHELASRE RRFYCWLSSV
KRLVLTPLRS RESASPSLGE PCTHLFFSLC ESFVRLSLLI GQHSTALSYF LHDVQGCDIA
SLPLLTHSEH FLDVYNEYCS SVGDFQVMGG FRPLHKLSLE CLGSQQAVLA QLCEPDQSAG
GKADLVSLLY WPLQQLHQYS RMLLKLAACY NVLTTEYQSL DQGGSRYDSQ SSSLLRRKKE
AETTSLFWSS HSGKTTEVLR LPQRRVVCES GNRSLTLQNA GRFSNHWFIL FNDTLVHTQF
STHHIYPLAS LWVKPVTEDG SGLYAIKITC PEESFTLVAS TPQEKNKWLR SLNQAVDHVL
GGAGQGSSPG LAAMSRTASH TFCGEGRFKD AHYTGAWVAG RIHGRGTMKW PDGRTYSGNF
KSGQEDGYGE CLIPDKVLNK PDGYQGHWRD GKIHGFGKYK YASGEVYEGC FCDGHRHGYG
MLSSGRMAKR SSSVFIGQWV HDKKTGYGVH DDITRGEKYM GLWLDEQRHG NATVVTQCGL
YYEGNFRDNK MCGPGLLVSD DDTALHGEFS EDWMVNGKGV LSLANGDSLE GMFSGEWTTG
LKVVGTYFKP SAGEPEHKER SGLLVCACSR LGQYAVPAAQ RWLCVFDECW SRLGCDSAGR
GERTAAWDSI AVTIATARRQ RCISPNLSRS QSKVLECLEC IPQHGEPVTT ANYDNIRRYL
IKACETPHHP LGWLVETLVT AYRMTYVGVG SNRRLLRLAV QEVLAYLTHF YRIVRFLFPG
LPDDGGIIPD PPTSTPESKQ KPDMSDQSLL SPCSGVVVLS FSSLLLPQLL PRLYPPLFTL
YCLQEEQEDA RYWERMLRLN KQPDRPLLRF LGVQEKFWPV WTSILGEKKQ IVSSSKDACF
VSAVETLQQI RRSTAFTPSD KLLVIQKTFE ELTQEVKLML DDSFLWCMDD LLPLFIYVVL
RARIRNLGAE VSLIEDLMDP NIQHGEMGLM FTTLQACYMQ ILQESAT
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