ID G3NXZ3_GASAC Unreviewed; 755 AA.
AC G3NXZ3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Kirre like nephrin family adhesion molecule 3, like {ECO:0000313|Ensembl:ENSGACP00000010213.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000010213.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000010213.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000010213.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; G3NXZ3; -.
DR STRING; 69293.ENSGACP00000010213; -.
DR Ensembl; ENSGACT00000010235.1; ENSGACP00000010213.1; ENSGACG00000007687.1.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00940000160603; -.
DR InParanoid; G3NXZ3; -.
DR OMA; TRIYDFS; -.
DR TreeFam; TF327139; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000007687; Expressed in diencephalon and 4 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0032836; P:glomerular basement membrane development; IEA:Ensembl.
DR GO; GO:0007520; P:myoblast fusion; IEA:Ensembl.
DR GO; GO:0072015; P:podocyte development; IEA:Ensembl.
DR GO; GO:0039022; P:pronephric duct development; IEA:Ensembl.
DR GO; GO:0039021; P:pronephric glomerulus development; IEA:Ensembl.
DR CDD; cd05759; IgI_2_KIRREL3-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11640:SF51; KIN OF IRRE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..755
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003448939"
FT TRANSMEM 493..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..102
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 110..214
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 221..297
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 306..386
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 390..486
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 542..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 755 AA; 81399 MW; 2FC35FE337A7F3FB CRC64;
MTALHLIFCC MVTAATQAAH FSQQPQDQVV VSGLSVTLPC VIVGYRGMVQ WTKDGLALGG
ERDLPGWKRY SLMGDPLSGE HSLLIDSAEL EDDAVYECQA TQAGLRSHRA KLTVLVPPSD
PVVEGGPVVR LKAHTPHNLT CRASGARPAA EITWYRDGEV METAIYSKTL LGDGKKEAAV
SMLPIVPEDS DSGRTYTCRV LNQAAPAGRQ ISVTINVQHP PSVTLSVQPQ TVAEGAKVLF
ICSASANPEI TGYRWSKGGV PISEANGDSL EVTVDYSYFT DPVSCEVSNS VGSTNVSTLV
DVQFGPRLLS EPKPMTVDMG MDAAFTCAWT GNPPLTLAWT KQGSSVVLSN SNTLQLKAVT
QEDAGTYTCK AIVPRIGVAE RDVTLTVNGP PILTVDATQH AVKHSKGKLE CRVGSSPPPE
KIVWTFGDTS LSSGSSGRFS VQTVTSDHGV SSALVLSETL AQDFQLRYNC TAWNRFGTGT
ALVTLKEQEA LPMLIIVGGA VGGGCVLLIC VITLVSLCCR HTGKGKRCTR LSKSDIRVQI
VHSDHNATRG NDDEEDVKEP MAPNSSESPG TSRTEHSDLL EEEEDERSES KDPTNGYYNV
RGNEDRHIRS SGFSEYVPNS RPVYTPSQLP SPSPVYGQHG TQPRVYDFSH RYATTTAGRT
AYEQQQAAQQ QQPAQPASIY PTDPVYSGSA YLPATYGRAF TSYVKPASYE KVDAYDQSDQ
ASKVSSSSRF SYASSQVSSQ QSDYGRPSQR MQTHV
//
