ID G3NYF0_GASAC Unreviewed; 1053 AA.
AC G3NYF0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Retinoblastoma-like 2 (p130) {ECO:0000313|Ensembl:ENSGACP00000010370.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000010370.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000010370.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000010370.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR AlphaFoldDB; G3NYF0; -.
DR STRING; 69293.ENSGACP00000010370; -.
DR Ensembl; ENSGACT00000010392.1; ENSGACP00000010370.1; ENSGACG00000007787.1.
DR eggNOG; KOG1010; Eukaryota.
DR GeneTree; ENSGT00950000183202; -.
DR InParanoid; G3NYF0; -.
DR OMA; MHWLACA; -.
DR TreeFam; TF105568; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000007787; Expressed in intestinal epithelial cell and 11 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 3.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR PANTHER; PTHR13742:SF8; RETINOBLASTOMA-LIKE PROTEIN 2; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Cyclin {ECO:0000256|ARBA:ARBA00023127};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 60..202
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 371..562
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 776..859
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 935..1053
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
FT REGION 598..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1008..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1026
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1053 AA; 116917 MW; 79A20855F4AE2A55 CRC64;
EDESVRKARS GFEDLCRALN MDEEARDDAW RSYEIASRNF TLEGSDLHWL ACSLYVACRS
SVPTGGKGTS GGNYVSLTRI LHCSEMSLIV FFNKMKKWQD MADLPQDFRQ STNKLERNFT
VSAVIFKKYV PIFKTIFRAP SEDPPRVHRS RKQRRHPCSV TEVFNFCWVL FVHAKGNFPM
ISDDLVNSYH LLLCALDLVF TNALLCNARK DLLNPNFRGL PEDFSSKDFR PSSGPYCFME
QLCELHDGLV LEAKGVKEHF WKPFIKKLFH KRIVRGKEDA LTGFLDPMNF GDSFLSLTRV
YEEHVLATGG LDERIFTGEG ASEDIGTPGP SVCGGLENQD KAAYRLHAAS ALKVSTPLTG
RRYVQENIRS SPVSSAMRSV GRLHTLLSGT RQGPSAKLAK TLRSCARDPS DVISKRLKDM
FELLCRHYEA GRAEEPPVDM AVKYFHLAEA LYYRMLESII EREKMILGDA DLSCILEQDV
FHRSLLVCCL EIVIFSNRPP GDFPNLMTIF QLPAYHFYKV IEVLVRSEQG LYREVVKHLN
QVEEQVLESL AWTSDSPLWE ILHGAKDQVP ACKQVCEPQH MSLFDLAVVQ VMPPQYLEQS
DESSGVPQTT VNLGPEPSAV SPSPPTLLDR YSSPPTGPFR RRLFIDSVDR EPRTATGTAP
TAMTKAGLVA AIAAGQTVVS MATATVTANN GQTVTIPVQG IANETGGITF FPVHVSVTGG
GGATLQPLSA QTLSGTRAVQ SAANKLAKPA KPAAGGTLRK GSVSLFFRKV YHLASVRLRD
LCSKLDISSG LRRKIWTCFE HSVVHCSNLM MDRHLDQLLM CAVYVMAKVT KEDKSFQTIM
KCYRTQHQAN SNVYRSVLIS GSLLPAGDIS PLPFHSSSHL APSQPSSAPS TPSTSSPTTP
STVGAGEEER GDLIHFYNHV YIKQMRLFAL RYSAGSPSAA LETPPLCPYP SLRTGSPRRM
LLSSKHSIYI SPHKTSPAPT ELTPQDKISY YISSSPTNRL QEINSMIRTG ETPTRKRSRP
LEEQTSPKRV CQENQSALLR RLQAVANDRG ASH
//
