ID G3NYN0_GASAC Unreviewed; 1463 AA.
AC G3NYN0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Protein 4.1 {ECO:0000256|ARBA:ARBA00023658};
DE AltName: Full=Band 4.1 {ECO:0000256|ARBA:ARBA00030419};
DE AltName: Full=Erythrocyte membrane protein band 4.1 {ECO:0000256|ARBA:ARBA00032586};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000010451.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000010451.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000010451.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 69293.ENSGACP00000010451; -.
DR Ensembl; ENSGACT00000010473.1; ENSGACP00000010451.1; ENSGACG00000007879.1.
DR eggNOG; KOG3527; Eukaryota.
DR GeneTree; ENSGT00940000157833; -.
DR InParanoid; G3NYN0; -.
DR OMA; ESIYVRH; -.
DR TreeFam; TF351626; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000007879; Expressed in heart and 13 other cell types or tissues.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13184; FERM_C_4_1_family; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR007477; SAB_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF12; PROTEIN 4.1; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF04382; SAB; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..283
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1246..1265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 375..470
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1463 AA; 166139 MW; D45155CB276C1A09 CRC64;
TMQCKVTLLD DTQFECELDK HAKVQELLTK VCDHVNLLER DYFGLVTLET PESKTWLEST
KEIRKQVSGG LYEFAFGVKF YPPDPAQLTE DLTRYFLCLQ LRKDIIHGVL PCSFVTLSLL
GSYTAQSELG EYDPELHGTD YVKDLSLAPG QNKELEEKVM ELHRTYRSMN PAQADLLFLE
NAKKLSMYGV DLHQAKDLDG IDITLGVCSG GLMVYKDKLR INRFPWPKVL KISYKRSSFF
IKIRPSEQEQ YESTIGFKLP NYKASKKLWK VCVEHHTFFR VPTVEPPSSR RFLVLGSKFR
YSGRTQAQTR QASSLIDRPA PRFTRSASKR LSRNLELLRQ LSASTRSEQD DWFLYFDQTF
SLSSLERVDR PLSRLTQLQL RLEDEQAMQK QTSEESFERL QESLILVDKL REMDDLKRRL
REVKDLEDRL TDMDEMAEHL QGAIEEELGR EEAEKLIREE NDVEQEEQIQ VRGITVSKKS
FSTTETKEEE VDELEEEEGA EIKREMEIEV ASESLSDDTL RGKLHQIKKE WQEKVEEKLK
SGFSDVTSTT SVVAYQVVEG RTGKRVPIVD EGALTQAEVE DVQRGVALEE TVEEEATWIK
TETPQAITEG EVTERLQAED RSPAADKDIW FILFELPPYK AVFKPPGTVS EISTFEERTE
TVEETTVRGG VWRVPEIPPP QTIMERDDDW FVWLDVVARE TSYVPPGTAQ TLPLLLVGVQ
EEMPKRPPPD RDDDWFVLLD VTPRESSYKP PVSVALKRSD QMGAESFVAV AATATQEDIE
EVVSEEKMMM DAEPRRPLAL RQPVLDRDDD WFVLLDAVPR ETPYVPPVAA ADRVEVSPEG
LVSVIPLTVG QEGEDGVGIE AADAELEGAL IEARVVALPV GVRERDDVWF VLLDVPERTP
TYVPPVTVAE YVEVAPEESI STAAETMTVE SRKEVIVEEL VVYKEDGGLQ EVSQPVRERD
DDDWFLLLDV VPREAPCVPP GTHRLQGPFI GFHTHYHTKE DYLTNSRDVT QTISVEPQPM
EAITTEQKLQ RVDAEQIRLE PSRPEREDDW FVLFDTIRQK AVAIPSGARS PLAAVDERLR
AHTEVRTAEE FSANKQRARQ AVAVVEETWR REAAVQQRPQ AAVREVEDDW FILMNVATKK
SEHCVFVLVV PERIQFLAEV SVPTAQAAST IARPERRAHF EKRILEERRP LAQTHVNDDW
FVLLDVAPKE SGTVRPSGFC RFADEQLAHM AALSSPRGTL RYVCRPSAGS ADSSSKNKNK
KKRIHKAHEG TVFPRSVRTY LISSRLDTDA FGPVVSTQRG ARPVSAPVFS QAALAEAGIP
MAPLDQPQTS TPIKTSRKEE RKLEVTVEAV EPSKTEAVAE KRAKRIEGDS IYIRHSLLML
EEFDKPQEDL LRHHASISEL KRNFMEAATE TRPSEWDKRL STHSPFRTLG INGQPLPSAD
GPWSHFHEAF QITSAAFAQL SLL
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