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Database: UniProt
Entry: G3NYZ7_GASAC
LinkDB: G3NYZ7_GASAC
Original site: G3NYZ7_GASAC 
ID   G3NYZ7_GASAC            Unreviewed;      4831 AA.
AC   G3NYZ7;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   28-MAR-2018, entry version 42.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSGACP00000010568};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000010568, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000010568}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000010568}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   STRING; 69293.ENSGACP00000010568; -.
DR   Ensembl; ENSGACT00000010590; ENSGACP00000010568; ENSGACG00000007942.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; REQWEKP; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 3.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007635};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4374   4392       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4438   4457       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4582   4610       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4631   4653       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4708   4731       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       82    137       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      144    189       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      197    251       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      257    320       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      322    379       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN     1014   1209       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1240   1449       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3908   3934       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4831 AA;  545632 MW;  3E10172DF036CC4F CRC64;
     DDEVVLQCVA TIQKEHRKFC LAVEGLGNRV CYLEPTSEAK YVPPDLCVCN FVLEQALSVR
     ALQEMLAKTG QNTEGAGHGG GHRTLLYGHA ILLRHSFSDM YLTCLKTSRS QTDKLSFDVG
     LQEDSIGEAC WWTIHPASKQ RSEGEKVRIG DDLILVSVST ERYLHLSISS GNIQVDASFM
     QTLWNVQPTC SAGSMAVGFL TGGHVMRLCH GHDESLTIPE AGKSEEENRI VNYEAGKGAS
     KARSLWRLEP LRISWSGSHI RWGQAFRLRH LATGHYLALT EDRGLVLQDR LKSDTKSTAF
     CFRTSKEKGD SSPKRDIDGM GVPEIKYGDS VCFVMHVATG LWLSYLAPDA KSSRLGPLKR
     RACLHSEGHM DDGLILQRCQ HEESRAARII RNSTILFTNF IKALDSIAER ESMAVSAYVE
     EVLQTLNDLI EYFKQPDLEL EHEEKQCLLR SLIKRQDLFK DEGMLALLSK CIDRMNLYNN
     AAHFGEMAGE EAGAAWKDIL NLLYELLAAL IRGNRINCTQ FSRNLDWLVS KLERLESSSG
     ILEVLHCILL ESPEALNIIQ RSHIKSIISL LYKHGRNHKI LDVLCSLCVC NGVAVRANQN
     LICDNLLPKR DLLLQTRLVN DVQSMRPNIF LGMAEGSAQY KKWYFEMVID QVDHFLTGQP
     THLRVGWANT KGYAPYPGGG EGWGGNGVGD DLYSYSFDGL HLWSGCCSNS HPSSLSVSAF
     CCPGRIPRAV ASINQHLLNS DDVVSCCLDL GAPSMSFRIN GQPVQGMFED FNTDGFFFPV
     VSFSAGVKAR FLLGGRHGDF KFLPPAGYSP CYEALLPKEK MHVEPVKDYK RDHDGVRDLL
     GTTQFLSQAS FVPTPVDTSQ IVLPPHLDNV RDKLAENIHE LWGMNKIELG WTFGKVRDDN
     KRQHPCLVDF GKLPETERNY NVQMSSETLK TLLALGCHVA QVYVNAADDL KKIKLPKDYM
     MSNGYKPAPL DLSDVKLNAG QEVLVDKLAE NAHNVWAKDR IKQGWTYGIQ QDLKSRRNPR
     LVPYAFLDER TKKSNRDSLR EAIRTMVGYG YDIDPADQEA IHVVNDQSID TIRFFRVEQT
     YAVKTGKWYF EFEALSGGDM RVGWARPGCR PDVELGTDDQ AFVFDGYMGR RMHAGSRYFG
     QPWKKGDVVG CMINMEDKSM IFTLNGELMI TSKGSELAFA DFETEDGFIP VCSMGMSQIG
     HMNLGKDAST FKYYTMCGLQ EGFEPFGVNM NRDITMWFSK RLPTFVNIPQ DHMHIEVTHK
     TFGTQNSNSD MTYCRMSMPV EFYSADKILD ESRKLSYPPK DGTVDYGSIT TYFHSVRVFA
     GQDPASVWVG WVTPDYHYYS KNFSLSKTRT VTVTLGDERG RVHESVQRSN CYMVCGADAV
     GPSSSSRSNS DLEIGCLVDL ATGLVSFTAN GKELPTTYQV EPNTKLFPAV FVRPTSANLF
     QFEFVKIKDA MPLSSAIFKS EQRNPVPQCP PRLDVQTIVA VLWSRMPNTF LSVETARVSE
     RHGWVVQCLE PLEMLAVHIP EENRCLDILE LSEHEDLRKF HYHTLKLYCA LCALGNTRVA
     HALCSHLDQS QLLNTIDNQY ISGMLREGFY NVLISIHLET AKEARLMMNN EFIIPVTDET
     RSIKLFPDES KRHSLPGVGL STSLKPRVNF SAVGVINTKR PLYLYSPQIP LGILKEKAIS
     MLTEAVQGGG THIRDPVGGS VEYQFVPILK LIGTLLTMGV LTSEEVRTIL LLIDPNVFGE
     AKDGEEAKGG EAAALSKPQV RGLLEKSLPE SVKRQMCELL HYFCDCELKQ RIEAIVSFSD
     SFVSKLQFNQ KFRYNELMLA FNMSAAVTAK KTKEFRSPPH EQINILLNFS AGEDCPCPEE
     IQDELNSFHE ELRLHCANLK ELISQTITSW AQESHIQDPE LVRVMFSLLR RQYDGIGELL
     RAMKKSYTIS AASVQDAINL LVSLGQIRSL LSVRMGKEEE KLMIDGLGDI MNNKVFYQHP
     NLMRVLGMHE TVMEVMVNVL GGDKSQEIAF PKMVASCCRF LCYFCRISRQ NQKAMFDHLS
     YLLENSSVGL VVNTYLCVCA CVASEAMRGS TPLDVAASSV MDNNSLALAL EEPDLEKVVT
     YLAACGLQSC AMLVAKGYPD LGWNPIEGER YLSFLRFVVF CNGESVEENA NVVVKLLIRR
     PECFGPALRG EGGQGLLAAM KEATKISEDP ALDLPKTPSV VTTGSGEGGG EVIHMGNAIM
     SFYSALIDLL GRCAPEMHLI NAGKGEALRI RAILRSLVPT TDLVGIISIP LKMPVLNKDG
     TVTEPDMAAS FCPDHKASMV LFLERVYGIE DQSFLLQLLE VGFLPDLRAS ASLDTEVLST
     TETALAMNRY IGSALLPLLT RCAALFSNTE HNAQLIDSTL QTIYRLSKGR SLTKAQRDAI
     EECLLAICKH LRPSMMQQLL RRLVFDVPML TEYCKIPIGL LTNHYDQNWK YYCLPSGMGS
     FGTASEEELL LTKKLFWGIF DSLSQKKYDA DLFKVAMSCL CAIAGALPPD FVDASLGTTL
     EKQASVDAQG NFDPKPINTA NISLPEKLEY VANKYAEHSH DKWSSEKASA GWKHGDGLDE
     RAKTHPLLKP YKALSEKERE TYRWPVRESL KSMLAMGWNI ERTKEGDAMF QQRESEKQRK
     TPESQGMVEI VAENYHNIWA KKKKPELVSK AKEKYRDREK AQELFKFLQI SGYIIIRGMK
     DMEQDSSSME KRFTYKFLKR LLKYIDSAQE FIAHLEAMAT SGKTDKSPHD QEIKFFAKVL
     LPLMDQTFKN HCLYFLSTPS KNMSSCGCAS SKEKEMVTSL FCKLAALVRH RISLFGSDSA
     MMNGDEVRLG AGQKRRRGPG EAAGDAETGQ VHAVPCPDEE RHAEHQLRDC GAAAHPHRPL
     WIANNAQLKD IFVFLVNILF VSVNDVQLSC FRILTCIYSL GIGKNVFVER HLPALGESLA
     TLVGAMPVAF LEPHLNGHNP LSVFNTKTPR ERAILSMPDT VEEMCPELPL LDKLLQDVSD
     VSESGARYND MPEVIEVILP MLCNYLSYWW EKGSENSPTG AQCCTMVTSE HLSLILGNIL
     KILNNNLGIE DAPWMKRIAV YSQPIICKAG ADLLRTHFLP TLNKLRLKTV KVVAEEELLK
     ADSKGDNQEA ELLILDEFAV LCRDLYAFYP MLIRYVDNNR CRWLKEPDED STELFRMVAE
     IFILWCKSHN FKREEQNFVV QNEINNLGFL TGEGKAKMSK NRMINKSGGD QERKHKRRRG
     EYYSVQTSLI VASLKKLLPI GLNMCSPGDQ ELIYLAKIRY SLKDTDDEVK EHLRQNFHLQ
     DKSEDPAVQW QLNLYQDVVV KSEEPINQEQ TVERVQSISA AVFHLEQVEQ PLRNKKCVRH
     KLLSKQRKRA VVACFRMAPL YNLPSRHRSI NFFIPAYQRL WIEAEEYSFE EKLVQDLAVS
     TGLALPLPRV PCVGAPLPVL SAECFFSAAP VEPWERTRVG TSPKAPRGGP RSKRAKPFKQ
     RSVRGQRLHD QLRRHRATSG TRVSKKAGYS FLTAVKTPMK IVEEEEEEVT EIQPDPLHQL
     ILHFSHNALT ERSYLEEDPL YIAYADMMAK VHFDVGIIPE KLDFNKMTFE EKEMEKQKIL
     YQQARLHARG AAEMVLQMSS ASKGCLGPMV TCTLKLGISI LNGGNVQVQQ KMLDYLKEKR
     DVGFFKSLSG LMQSCSVLDL NAFERQNKAE GLGMVTEEGS SSKVLQNDEF TKDLFRFLQL
     LCEGHNGADF QNFLRTQTGN TTTVNIIIST VDYLLRLQES ISDFYWYYSG KDIIDETGRV
     NFSKALSVAK QIFNSLTEYI QGPCIGNQQS LAHSRLWDAV VGFLHVFANM QMKLSQDSSQ
     IELLKELMDL QKDMIVMLLS LLEGNVVNGT IGKQMVDTLV ESSSNVEMIL KFFDMFLKLK
     DLTSSDNFRE YDPECKGMIS KKEFQKSMES QMQYSQSEIG FLLSCAEADE NDMFNYKEFV
     ERFHEPAQDI GFNMAVLLTN LSEHMPHDSR LATFLDLAGS VLSYFEPYLG RIEIMGSAKR
     IERVYFEISE SSREQWEKPQ VKESKRQFIF DVVNEGTESE KMEMFVNFCE DTIFEMQLAS
     QISEPDVVDQ PEEEDEEEAH SFLDELAAEE EAALESVSAF TSACRSVKKK IGHLRQTCSV
     KNVRKQFKRF KKLSIKEIIT GFFSFFWMLF TGFFKGIYGL IFGFFHIVWS SMFGGGLVEG
     AKNIKVTDIL GNMPDPTQFG IHGDAIEREK VEAVESSGRS DAAMAPAGDV EVDAMLEILS
     NPKKEGGKHV EPGLGDVSEL SAETSPTDQK KKAAAQPAKA PENEAEKADT ENQEKEDKPK
     KEEEAKEPVV EEKPKTRSSQ PKEASPAFML TVFAFLKVYL TKLLNFLARN FYNLRFLALF
     VCFAINFILL FYKVTADPDE EIDEEKTWDG EEDDGLNTFF DMDEFVLQES SGYMLPTLRF
     LAVFHTVISL VCLFGYYCLK VPLVVFKREK EIARKLEFDG LYITEQPSDE DIKGQWDRLV
     INTPSFPSNY WDKFIKRKVI NKYGDLYGAE RIAELLGLDK SALDFDPTVE TVEKEASLLS
     WLSSIDTKYH IWKMGVVLTD NYFLYLIWYS TVSIFGHFNN FFFAAHLLDI AMGIKTLRTI
     LSSVTHNGKQ LMLTVGLLAV VVYLYTVVAF NFFRKFYNKS EDEDEPDMKC DDMMTCYLFH
     MYVGVRAGGG IGDELEDPAG DVYELYRILF DITFFFFVIV ILLAIIQGLI IDAFGELRDQ
     QEQVKEDMET KCFICGIGND YFDRTPHGFE THTLQEHNLA NYLFFLMYII NKDETEHTGQ
     ESYVWKLYQE RCWDFFPTGD CFRKQYEDQL G
//
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