ID   G3NZK6_GASAC            Unreviewed;       964 AA.
AC   G3NZK6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=SH3-domain binding protein 4 {ECO:0000313|Ensembl:ENSGACP00000010779.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000010779.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000010779.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000010779.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC       {ECO:0000256|ARBA:ARBA00004132}. Membrane, clathrin-coated pit
CC       {ECO:0000256|ARBA:ARBA00004600}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}. Vesicle
CC       {ECO:0000256|ARBA:ARBA00004373}.
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DR   AlphaFoldDB; G3NZK6; -.
DR   STRING; 69293.ENSGACP00000010779; -.
DR   Ensembl; ENSGACT00000010801.1; ENSGACP00000010779.1; ENSGACG00000008147.1.
DR   eggNOG; ENOG502QTUW; Eukaryota.
DR   GeneTree; ENSGT00390000013151; -.
DR   InParanoid; G3NZK6; -.
DR   OMA; HRIRANN; -.
DR   TreeFam; TF105572; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000008147; Expressed in testis and 7 other cell types or tissues.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.220.30; -; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR15603:SF3; SH3 DOMAIN-BINDING PROTEIN 4; 1.
DR   PANTHER; PTHR15603; SH3 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 2.
DR   PROSITE; PS51145; ZU5; 1.
PE   4: Predicted;
KW   Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW   Membrane {ECO:0000256|ARBA:ARBA00023176};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          57..116
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          319..454
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
FT   DOMAIN          654..724
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
SQ   SEQUENCE   964 AA;  107077 MW;  9448E89D463290B7 CRC64;
     MAAHRIRAAT SNNAPLPRCK SEGTLIDLSE GVSEASLNDV KVPSPSTLRL DATATFGAAR
     EVVAIKDYCP SSFTTLKFCK GDRLYVLDST GGEWWYAHNN TEMGYIPAAY VEPINFRDSS
     FSDSGMIDTV GDCPEDAAQE TDLLGEWAGV ILKPTIFQNG NPFATTHTST NPFLNKGPQS
     SLDQNSNEKS VDLLLFDTLA TSVHNSTSST AANGLGNGVF NPLSPTVGVG QVLRRDNPFF
     RSKRSYSLSE LSILQAQSDA PPASSSFFGG LKAPAPEQFQ SREDFRTAWL SHRKLARSCH
     DLDSLGQNPG WGQTQPVETN IVCRLDSSGG AVQLPDSNIS VHVPEGHVAP GDTQQISIKA
     LLDPPLELNN DRCTTVSPVV EIKLSNMETK TNVTLDMKVS VVVKMESRET TEVLCVRSDC
     KEGPYTPIPQ AYMYGDTVQV CLDNLEPCMY VCVVAQSRSL SPDSTVWEHV VKKITLGVYG
     PKHIHPSFKT VVAMFGHDCA PKTLLVSEVG KQAQSAPSVL LQLWGKHQFV LSKPQDLRVG
     VYSNMANYEV KVSEQARVVR GFQVKLGKVS RIVYIIASRN TDDVSDFTLR IQVKDDQDCI
     LAQFCVQTPP PPPKAGPKTS VQRRFLKKKE VGKIVLSPLA IATKYPVFQD QRINNLKFGK
     LIKTVIRQTK NQYLLEYKKG DFVALLSEER IRLKGQLWTK EWYIGYYQGK MGFVHAKNVL
     VVGKVKPIYF SGPDLSTSLL LEQILKPCKF LTYIYASVRT ILMENIGNWR AFADSLGYGN
     LPLTHFCRAE LDSEPERVAS VLERLKEDCN NTESKERKSF QKELLTALLK MDCQGLVARL
     VMDFVLLTTA VEVAGRWREL AERLVKVSRQ QMDAYEAPHR DKNGVVDSEA MWKPAYDFLV
     TWAAQIGDSY RDVIQELHMG LDKMKNPITR RWKHLTGTLI LVNCLDALRS SAFSPAAQDD
     DYAI
//