ID   G3P0H1_GASAC            Unreviewed;       812 AA.
AC   G3P0H1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN   Name=OSBPL3 {ECO:0000313|Ensembl:ENSGACP00000011094.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000011094.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000011094.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000011094.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
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DR   AlphaFoldDB; G3P0H1; -.
DR   Ensembl; ENSGACT00000011117.1; ENSGACP00000011094.1; ENSGACG00000008359.1.
DR   GeneTree; ENSGT00940000155957; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000008359; Expressed in testis and 4 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041680; PH_8.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF15; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 3; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF15409; PH_8; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          49..144
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   812 AA;  91905 MW;  C17783C2EBCA0E04 CRC64;
     SEERSSAMSQ KISSASRSNS SASSKLDSRQ DSWEIVEGLR GGFSSVLEPQ KQEGFMLKRR
     KWPMKGWHKR YFFLDKGILK YGKCSADIER NKLHGCIDVG LSVMAIKKKA KCIDFDAEEN
     IYHLKIKSQE LFDEWVSKLR HHRLYRQNEI ALYPTEKSFY YPHYPSPISS SMAESASIRK
     RQSMGNSAGD FPPSCHSQAK VAAWLQSSDD MDKCSKDLSV CEAGLLELSH LLQSMEVLHR
     TYSAPSIQAL QVPSCISSGS IRLHASNPNL STAALANDKA DTESVDSTFD VAKLHEDFFR
     VATNLHLTMK TALSSLTSER ERLKQCVNHE TIPPTSPRVV GLKNTLATKQ DSVDDSRPLV
     HQISNESGAS ITESMTEFFD AQEVLLSASS SENEVSEDDS YISDISDNIS IDNLSNETEG
     ERPNSDTVAE GSVLYQRRSC LPSPSPNNST ISLWNILRNN IGKDLSKVAM PVQLNEPLNT
     LQRLCEELEY SELLDKAANT QDPFERMVYI ATFVVSGYAS SYYRTGGKPF NPVLGETYEC
     ERPDKGLRFV AEQVSHHPPI SACHAESKNF LFWQDVRCKN KFWGKSMEIV PVGTTHVTLP
     GFGDHYEWNK VTSCIHNILS GQRWIEHYGE ISIRNSSSDI CQCKITFVKA KYWNSSGNEV
     EGAVTDNKGK VVHRLFGKWQ EAVFCGDPPS ATCVWRANAM PVDLEQYYGF TKFAIELNEL
     DPSLQLLLPP SDTRLRVDQR LLETGNLEAA EEHKQRIEEL QRERRKVLEE NNETHQPKFF
     RKSKDDTWVS NNTYWELRKD PGFTQIDFPV LW
//