ID G3P0M6_GASAC Unreviewed; 883 AA.
AC G3P0M6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Eosinophil peroxidase {ECO:0000313|Ensembl:ENSGACP00000011149.1};
GN Name=EPX {ECO:0000313|Ensembl:ENSGACP00000011149.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000011149.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000011149.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000011149.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR AlphaFoldDB; G3P0M6; -.
DR Ensembl; ENSGACT00000011172.1; ENSGACP00000011149.1; ENSGACG00000008429.1.
DR GeneTree; ENSGT00940000156009; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000008429; Expressed in pharyngeal gill and 4 other cell types or tissues.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR Gene3D; 1.20.5.320; 6-Phosphogluconate Dehydrogenase, domain 3; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11475:SF63; EOSINOPHIL PEROXIDASE; 1.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR Pfam; PF00386; C1q; 1.
DR PRINTS; PR00457; ANPEROXIDASE.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
PE 4: Predicted;
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..883
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003449074"
FT DOMAIN 756..883
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 131..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..756
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 483
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ SEQUENCE 883 AA; 98713 MW; 4FF2B987CBC9BA33 CRC64;
RQQLLFLFKV NCVCFLLIRL SESHLSRSAI ERAVIAAKAT VDSAYEYSRR VSVDRVRRNA
VSPSDVLRLL KQPAGATRNA VRSADYMENA VKLIQASLHR RQKRSINATD LISAEDLKFI
AELTGCSARR QNPTCPTESK FRTPSNTCNN RKNPRWGASN TPFARWLPAE YQDGISLPKG
FDPERKVNSF VLPLVRAVSN NILKTAKADV EIDPLYTYLV TIFAQWTDHD LTLTPTSPVI
RSFNNGMDCA KSCENSEPCF PIKFPKNDPR NASEECIPFF RSAPACGSGN TGHIFGASTV
RQQINSLTAF LDVGQVYGSE DTKVRFLRNL TSNEGLLRVN TRFDDNGREL LPFSSMTTNM
CATRKRITND SFAEEVPCFV AGDDRVDENI GLNSLHTLFM REHNRLARAL AKLNPHWDGE
RLYQEARKIM GGYTQVLTFR DFLHHIVGPD FIASHLSTYP GYDENVDPSI ANVFATAAFR
FAHLMVQPKM FRLNEQYEEH PVYPSPLLHK SFFAPWRVVF EGGVDPLIRG LVGRQAKLNT
QDNMMTDELR DRLFQFTQKL ALDLASLNMQ RARDHAIPGY NQWRKFCGLS QPKNLNELSQ
VLNNRDLAKR LLDLYSTPDN IDVWLGGVAE PFVRGARVGP LFACLISTQF QRIRQGDRLW
WENDGVFTDA QKNSLRSTSL ARIICDNTGI TEVPEKPFQY RPRGTGYTKC ENIAPFDLGP
WKENSNERGP PGPPGPSGPS GPPGPPGPPG PPGPPGSAHK VAFSVRLGNN FPKPGVPLVF
RDVIYNGQNS YDTSTGVFTC AQPGVYEFQF HCTIHDGTGS VDLIRNSKLI LHSFTTTQSG
YLIASGSVYV KLDKGDRVYL VANYGGNGLT TDSYFSGHLL FTE
//