ID G3P151_GASAC Unreviewed; 446 AA.
AC G3P151;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Pachytene checkpoint protein 2 homolog {ECO:0000256|ARBA:ARBA00022364, ECO:0000256|RuleBase:RU369050};
DE Short=TR-interacting protein 13 {ECO:0000256|RuleBase:RU369050};
DE Short=TRIP-13 {ECO:0000256|RuleBase:RU369050};
DE AltName: Full=Thyroid hormone receptor interactor 13 {ECO:0000256|RuleBase:RU369050};
DE AltName: Full=Thyroid receptor-interacting protein 13 {ECO:0000256|RuleBase:RU369050};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000011324.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000011324.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000011324.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a key role in chromosome recombination and chromosome
CC structure development during meiosis. Required at early steps in
CC meiotic recombination that leads to non-crossovers pathways. Also
CC needed for efficient completion of homologous synapsis by influencing
CC crossover distribution along the chromosomes affecting both crossovers
CC and non-crossovers pathways. {ECO:0000256|RuleBase:RU369050}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369050}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family. PCH2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007271, ECO:0000256|RuleBase:RU369050}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3P151; -.
DR STRING; 69293.ENSGACP00000011324; -.
DR Ensembl; ENSGACT00000011347.1; ENSGACP00000011324.1; ENSGACG00000008559.1.
DR eggNOG; KOG0744; Eukaryota.
DR GeneTree; ENSGT00390000017432; -.
DR InParanoid; G3P151; -.
DR TreeFam; TF313507; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000008559; Expressed in testis and 3 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd19508; RecA-like_Pch2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR044539; Pch2-like.
DR PANTHER; PTHR45991; PACHYTENE CHECKPOINT PROTEIN 2; 1.
DR PANTHER; PTHR45991:SF1; PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG; 1.
DR Pfam; PF00004; AAA; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003651};
KW Differentiation {ECO:0000256|ARBA:ARBA00022943};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254, ECO:0000256|RuleBase:RU369050};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003651}; Nucleus {ECO:0000256|RuleBase:RU369050};
KW Oogenesis {ECO:0000256|ARBA:ARBA00022943};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT DOMAIN 176..328
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 446 AA; 50275 MW; 0F8E3AEFA38B45A4 CRC64;
QLAGTKAMRR TVGDRMELEN QKQNIDVEVH VKSHSTAKKS EVRIQVLGLL NRHGMLFGNY
KWTEFDKEFL QKNVESVAIV DLLFSSLTYF SQPLDLKSYS VSIHIFTLNE DGPSTLSLEE
DEELSAANHW LLPAAEFNGI WESLVYESGV KTQLLNYIST TIYFSDKNVD SNLISWNRVV
LLHGPPGTGK TSLCKALAQK LSIRLSSRYS YGQFVEINSH SLFSKWFSES GKLVTKMFQK
IQQLIDDKEA LVFVLIDEVE SLTAARSASQ AGTEPSDAIR VVNSVLTQLD QIKRHSNVVI
LTTSNVTQKI DLAFVDRADI KQYIGPPSEK GIYNIYLSCL EELMKVTELS GRVFSFFFGI
KNQNGNLQVV IRNTFAVTSW NTSTFKLMYL RKGRSKGLSG RALRKLPFLA HALFVKTPTV
TLERFLEAMT QAVDKQMEET ANLVNA
//
