ID G3P167_GASAC Unreviewed; 519 AA.
AC G3P167;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Vitronectin a {ECO:0000313|Ensembl:ENSGACP00000011340.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000011340.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000011340.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000011340.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3P167; -.
DR STRING; 69293.ENSGACP00000011340; -.
DR Ensembl; ENSGACT00000011363.1; ENSGACP00000011340.1; ENSGACG00000008584.1.
DR eggNOG; KOG1565; Eukaryota.
DR GeneTree; ENSGT00530000063751; -.
DR InParanoid; G3P167; -.
DR TreeFam; TF332780; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000008584; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00094; HX; 1.
DR Gene3D; 4.10.410.20; -; 1.
DR Gene3D; 2.110.10.10; Hemopexin-like domain; 2.
DR InterPro; IPR000585; Hemopexin-like_dom.
DR InterPro; IPR036375; Hemopexin-like_dom_sf.
DR InterPro; IPR018487; Hemopexin-like_repeat.
DR InterPro; IPR020436; SMB_chordata.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR22917; HEMOPEXIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22917:SF7; VITRONECTIN A; 1.
DR Pfam; PF00045; Hemopexin; 3.
DR Pfam; PF01033; Somatomedin_B; 1.
DR PRINTS; PR00022; SOMATOMEDINB.
DR SMART; SM00120; HX; 4.
DR SMART; SM00201; SO; 1.
DR SUPFAM; SSF50923; Hemopexin-like domain; 2.
DR SUPFAM; SSF90188; Somatomedin B domain; 1.
DR PROSITE; PS51642; HEMOPEXIN_2; 4.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..519
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003449258"
FT DOMAIN 18..60
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT REPEAT 157..201
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 202..249
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 250..310
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 455..511
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REGION 69..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 59549 MW; 2E05A78B7DA73709 CRC64;
MRLWAVLPLA LLARTFAADE SCMGRCENGF DSRMKCQCDS MCKYYRSCCY DFEVTCGMTT
RGDTFVFAED DDSEPFEDTT PSAGRPAHDP SSSVIDHQPR PLPEQITPIS QTFTPTETVL
SNTRPSAGDA AAETTTGAAT TAAPTKAPDP DAVVCSRRPF DSFMQQKNGS IFAFRGEYFF
ALDRQSVLPG YPKLIKDVWG ISGAIDAAFT RLNCQGKTYI FKGDKYWRFD NGVLDDDYPR
DISVGFDRIP DHVDAAFALP APGYNGKEKV YFFKGGQYHV YEFLHQPSHE ECITMTERSP
STLFRHYTDL YYNNYERVIS ELFSGTPQHH DRHHFIDKDW KGLKSPVDAV MAGRMYVPPG
RLAQPHNDDW PDQRGAEGRG QQWNQQYQQY GQQWDQQYGQ RWGRRRQRRS PFWGSVAERG
MNIGQGFAED RLWDQDWDQD RRNDGYRHNN RGNYDSRDDG SYWGPIRGLL PVQSVYFFRG
ETYYRVDLRT KKVDHANPPY PRSIAKYWLG CSDTTGAEK
//
