ID   G3P348_GASAC            Unreviewed;       845 AA.
AC   G3P348;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Rubicon autophagy regulator {ECO:0000313|Ensembl:ENSGACP00000012021.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000012021.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000012021.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000012021.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; G3P348; -.
DR   Ensembl; ENSGACT00000012045.1; ENSGACP00000012021.1; ENSGACG00000009086.1.
DR   GeneTree; ENSGT00940000165727; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000009086; Expressed in spleen and 12 other cell types or tissues.
DR   GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   CDD; cd17686; RUN_RUBCN; 1.
DR   Gene3D; 1.20.58.900; -; 1.
DR   InterPro; IPR025258; RH_dom.
DR   InterPro; IPR048569; RUBC_PIKBD.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   PANTHER; PTHR45971; PHOX (PX) DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45971:SF3; RUN DOMAIN BECLIN-1-INTERACTING AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF13901; RH_dom; 1.
DR   Pfam; PF21054; RUBC_PIKBD; 1.
DR   Pfam; PF02759; RUN; 1.
DR   SMART; SM01175; DUF4206; 1.
DR   SMART; SM00593; RUN; 1.
DR   SUPFAM; SSF140741; RUN domain-like; 1.
DR   PROSITE; PS50826; RUN; 1.
PE   4: Predicted;
KW   Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT   DOMAIN          1..127
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   REGION          191..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          441..485
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        191..218
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        239..259
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..298
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        330..355
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        444..470
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   845 AA;  93791 MW;  69B829C4717CD476 CRC64;
     MNNILSHGLK NEQVYYKKRD YWPFVWCVRY ISPHLASHVE QFSQLQPVLS SGMQQSTGGE
     SYKAERWLLH SLQVHLLSAQ LRPLLRHLGH TRKYYNEDAF LLSEPHVTAM FQCLEAVEQN
     NPKLLAQVDA FGLSPLKGPP CLGLLKSQSL CVLPGPGAVW RNADSAPTRE SLNRRLTTSF
     CSLKETVAAS HNSGNTTGGG SQNNNGNCTN TSFPASSRGA PCVSKPGESG RGGTPPPGSV
     SVPSISLSKP PSSPSLQPEA GDSGDGDYDD GPEYLAIGNL GQRSRSDSPN STDSSEQGVA
     PALAPPPHRR SSFSAGQRGP GRAPRGHTRS FSDTGVSQKM KNDVSQVNSV PDGMFRKPSQ
     GQSLISYLSE QDFGSCADLE KENAHFSISE SLIAAIELMK YNLRRQEEEG EEEGDSDSEI
     QQLKQKIRLR RQLIRRSRVP PCANSHIVHS TDSGGSRRSS QDSYQGLSDS GSAEEVEECE
     LRDADIKRSV SSSSRSFLSS ESISPSYLQS NSAESVAMGL LRQFEGMQLP AASELDWLVA
     EHDAPQKLLP IPDSLPISPD DGEHADIYKL RIRVRGNLEW APPRPQIIFN IHSAPKRKIL
     VVKQNYRCAG CGTRIDPDYI KRMRYCEYLG RYFCQCCHEN AQAVVPGRVL RKWDFSKYYV
     SNFARDLLSK IAGDPLFNPS DINSGLYKKV KALEVVRVLR VQLFHMKNLF KTCRFAKEVL
     EQFDSLPGHL TEDLHLFSLS DLSAVRSGEM APRMKELLKL GTAHVAGCVL CQAKGFVCEF
     CSNDKDIIFP FQLNKCQRCE ECHACYHSGC FRPRKDCPRC RRLAERRERM ARKNMEEQED
     EGGGP
//