ID G3P3J2_GASAC Unreviewed; 1283 AA.
AC G3P3J2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Tonsoku-like protein {ECO:0000256|ARBA:ARBA00017829};
DE AltName: Full=NF-kappa-B inhibitor-like protein 2 {ECO:0000256|ARBA:ARBA00033240};
DE AltName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 {ECO:0000256|ARBA:ARBA00030801};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000012165.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000012165.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000012165.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC -!- SIMILARITY: Belongs to the Tonsoku family.
CC {ECO:0000256|ARBA:ARBA00010999}.
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DR STRING; 69293.ENSGACP00000012165; -.
DR Ensembl; ENSGACT00000012189.1; ENSGACP00000012165.1; ENSGACG00000009209.1.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000160188; -.
DR InParanoid; G3P3J2; -.
DR OMA; FLESECC; -.
DR TreeFam; TF326440; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000009209; Expressed in head kidney and 1 other cell type or tissue.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46358; TONSOKU-LIKE PROTEIN; 1.
DR PANTHER; PTHR46358:SF1; TONSOKU-LIKE PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13424; TPR_12; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00368; LRR_RI; 3.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803}.
FT REPEAT 445..477
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 478..510
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 514..546
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 387..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..420
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 779..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1283 AA; 140248 MW; 78EB4079635A72CE CRC64;
MGNIEAALKN QQCHLDLARS VGDYAEEQRA LATIGRTYLF RYESDQSKNS LSQAEEVFKK
SLCIVDEHLE GTVPEREIRE MKARLFLNLG LVCDHLGEHK RCSEFIRRSV FIAEKSHLLE
DLYRANFNLG NIYFRHGQWS KAVRCLEQAK ECARKIKDKF SESECFHCIG KVQLSLADFV
AARRSLKKAV LLGSQQPLDR QTVKRAFKYA DLGCKLEEEL GEDPVKGLGS HRAVGLAERL
GDLYCKVGCY GKALDAYQAQ LAGAEALGKP ARELAVIHVS LAATYTDLRQ HSKAVEHYRQ
ELALRQGSPT EECGTWLNIA AAQEESGCSL EEIESSYGAA ADCVQKAGQT RLQKRALRLW
LAAQRRRGSS GAEDTEARLQ ELCAAEGWCP DGSDGEGDEE EEMDNSEPLD DSDVVLSDSD
DDLEGYDKMV SGRRKAGRWN KRNEKGETTL HRACIDGNLK QVQYLVEQGH PVNPRDNCGW
TPLHEACNHG HYDIVSVLLE YGANINDPGG PSCEGVTPLH DALSCGHFTV ARLLVERGAS
VTQRGETVMD TLHKWQRTYR RELDEDTKQE CVTTEAVLRK ALAGGVTAAP TPAKAFGALQ
DSQLFDAEMS EPLLSSGTGC PSSQDRPRTN RSTEVKAAPA SPTRWKSNGS ATRHRARNQS
SSSEDSDSDC PPAAPSQKEA PAHRENNAAP NSGRESLREA PGPSVFAREE YHSAIRGVGS
AKTLLQGLSQ PQYSSTAAVP SSNKSALVPE EEYLADDWLE DDLGEIQPKK KRRLGADQTR
SQNRLFNSDT ASRSNYQESL CEKEQLSEAS PGENDSDARD GQPPAQCVAA SMQRSLPPPI
RMRVRVQEDV FLIPVPQREA DSCTVSWLCE QAAQRYYQKC GLLPRLSLQK EGALLSPQDP
LLAVLHTNEE VLAEVSSWDL PPLPERYKKA CDSLAVGENK RVTRLCEVQD GSSSVSVCGL
SLAASCLNPL LRALKLQASL TELRISGNRL HDNLVPELVA ATITMPRLRL LDISANGITG
DGLEKAIDAL KGQSHPAFPC LEELDLSMNQ LGDGVSESLS CLLSCCPLLA KLSLQACGLT
ARFLQQHRLL LANALTGTGH LKSVCLSHNA LGSTGFELVL KTLPLHCLTH LDLSAVCRGP
ADYPALEHLA KILSQDECSL THLSLAANGL TDSSVATLAR LLPSCPSLVS LNLSGNPSVT
SAALHNILIS LREARRPLTL LNLQGCEVSG PWDGAGLAGL SELVKDLRLC SQGLNKLDRQ
ALKQSWETSR SRGRFVDRNS KCL
//
