ID   G3P458_GASAC            Unreviewed;       232 AA.
AC   G3P458;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=1-alkyl-2-acetylglycerophosphocholine esterase {ECO:0000256|ARBA:ARBA00013201};
DE            EC=3.1.1.47 {ECO:0000256|ARBA:ARBA00013201};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000012381.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000012381.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000012381.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-O-
CC         hexadecyl-sn-glycero-3-phosphate + acetate + H(+);
CC         Xref=Rhea:RHEA:41704, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30089, ChEBI:CHEBI:77580, ChEBI:CHEBI:78385;
CC         Evidence={ECO:0000256|ARBA:ARBA00035804};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41705;
CC         Evidence={ECO:0000256|ARBA:ARBA00035804};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-
CC         O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+);
CC         Xref=Rhea:RHEA:40479, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30089, ChEBI:CHEBI:44811, ChEBI:CHEBI:64496;
CC         Evidence={ECO:0000256|ARBA:ARBA00023721};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40480;
CC         Evidence={ECO:0000256|ARBA:ARBA00023721};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-
CC         alkyl-sn-glycero-3-phosphocholine + acetate + H(+);
CC         Xref=Rhea:RHEA:17777, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30089, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707; EC=3.1.1.47;
CC         Evidence={ECO:0000256|ARBA:ARBA00023737};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17778;
CC         Evidence={ECO:0000256|ARBA:ARBA00023737};
CC   -!- SIMILARITY: Belongs to the 'GDSL' lipolytic enzyme family. Platelet-
CC       activating factor acetylhydrolase IB beta/gamma subunits subfamily.
CC       {ECO:0000256|ARBA:ARBA00038184}.
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DR   AlphaFoldDB; G3P458; -.
DR   STRING; 69293.ENSGACP00000012381; -.
DR   Ensembl; ENSGACT00000012405.1; ENSGACP00000012381.1; ENSGACG00000009368.1.
DR   eggNOG; KOG1388; Eukaryota.
DR   GeneTree; ENSGT00950000183199; -.
DR   InParanoid; G3P458; -.
DR   OMA; HHRFIAD; -.
DR   TreeFam; TF323955; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000009368; Expressed in telencephalon and 13 other cell types or tissues.
DR   CDD; cd01820; PAF_acetylesterase_like; 1.
DR   Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR   InterPro; IPR013830; SGNH_hydro.
DR   InterPro; IPR036514; SGNH_hydro_sf.
DR   PANTHER; PTHR11852; PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE; 1.
DR   PANTHER; PTHR11852:SF9; PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE, ISOFORM IB, GAMMA SUBUNIT; 1.
DR   Pfam; PF13472; Lipase_GDSL_2; 1.
DR   SUPFAM; SSF52266; SGNH hydrolase; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT   DOMAIN          44..204
FT                   /note="SGNH hydrolase-type esterase"
FT                   /evidence="ECO:0000259|Pfam:PF13472"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   232 AA;  25541 MW;  DDE8AB287D138898 CRC64;
     MSAEDPNPAA TPTPCEDTQG DGRWISLHNR FVSDSKDKEP DVLFVGDSLI QLMHQFGIWR
     QLFSPLHALN FGVGGDATQH VLWRLSNGEL DNISPKVVVL WVGTNNHGQT AEQICEGIMA
     IIQVIKNKLP NARTLVLGIL PRGKSPNALR ERNAKVNKLV QEAVLSLPHA SFLNVDPGFV
     HSNGSISHHD MYDYLHLTPQ GYQAVCEPLH AHLKSMLDKP AEKSLPFASS PP
//