ID G3P4B6_GASAC Unreviewed; 1032 AA.
AC G3P4B6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Sortilin related VPS10 domain containing receptor 1 {ECO:0000313|Ensembl:ENSGACP00000012439.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000012439.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000012439.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000012439.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR AlphaFoldDB; G3P4B6; -.
DR STRING; 69293.ENSGACP00000012439; -.
DR Ensembl; ENSGACT00000012463.1; ENSGACP00000012439.1; ENSGACG00000009419.1.
DR eggNOG; KOG3511; Eukaryota.
DR GeneTree; ENSGT01030000234563; -.
DR InParanoid; G3P4B6; -.
DR OMA; QQRCTSD; -.
DR TreeFam; TF324918; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000009419; Expressed in telencephalon and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR CDD; cd00146; PKD; 2.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 951..971
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 672..728
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
SQ SEQUENCE 1032 AA; 115827 MW; D2F6ED0CDA268FB3 CRC64;
ASFSDQEEFE LPSSTFALSG DTAHNQAMVH WSGQNSSVIL MLTKYYDFNS GRVTESSLWR
STDYGTTYEK LNEKVGPKTI LSYLYVSPNN KRKIMLLTDP EVDSSLLISL DEGATYEKHG
LAFDILSLLF HPEQEDWILA YSHDQKLYVS VEFGRRWQLV QDGVIPNRFY WSRLGLDKEQ
GMIHLEISVS DGRSQYITCK LQNCSDGNKG KPFPGFIIPN SLVVQDEYVF IQVPVGGQSV
HYVSYKRNAF YPMKLPKYTL PKDLQIISTD DNQVVAAIQD RHQNDSYNLY MSESRGLFFT
LMLENAVSSG GPEGNIMIDL YEVAGIKGVF LSNKVVENQV KTYITYNKGR DWRLLHAPTT
DLQGNKVYCE QPYCSLHLHL HVSENPYTSG NIVSKDSAPG IIIASGVVGP ELTSNNVSIF
ITSDAGNTWR EVFQEEYSVF FLNQGGSLVA IRHTPLPIRH IWLSFDEGRN WDKYSFTSSP
LYVDGVLGEP GEDTLIMTIF GHFSHRSEWQ LIKTDFRSIF QQRCTSEDYM TWQLHNEGEV
CIMGMKRIFQ KPKANVRCVN ARNQYISQMS NSCPCTEADF ECDYGFERQV DRSCAPSFWF
VPTATSRDCI RGDSFLNTTG YRRAFSNNCT DGALLKYSPT RQKCPSQAPR GLQLFTSEGT
LVATLDRNVT FLVFLEEGLG SMTSITVDFG DGTAISYVNI SSIDDGVKHI YSRVGIYQVS
ATATNTLGFD RVILYLHVSC QLEQVQLSAP SVVVKNKAVN LTTVLRPNNV GTVSYYWWFD
NKTEPVVTLD GTMSFTFSKE GRHTVTVQAS VGNTVHQDQM TVTVYDYFRS YVLGFSSNLD
EQNPGMSEWR EDISRVVKSN MVQVTGINDE QLLVTVIPGL PTTAEIFIVP EKKARGGGMD
EKWAHLDQVL LSALNQDLIQ FTLKPGVQVN VYATQLSPAP LVDSSDSGHS ATAVIMLVSV
VLMGLAVFVI YKFKRKIPGI NTYTAEQPDK EQEVIPTVTS IDIPNPEGEK LTSLDHVDVQ
LDSRARGSYA FS
//
