ID G3P6Z0_GASAC Unreviewed; 1198 AA.
AC G3P6Z0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPN14 {ECO:0000313|Ensembl:ENSGACP00000013364.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000013364.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000013364.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000013364.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649}.
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DR AlphaFoldDB; G3P6Z0; -.
DR STRING; 69293.ENSGACP00000013364; -.
DR Ensembl; ENSGACT00000013389.1; ENSGACP00000013364.1; ENSGACG00000010112.1.
DR eggNOG; KOG0792; Eukaryota.
DR GeneTree; ENSGT00940000156874; -.
DR InParanoid; G3P6Z0; -.
DR OMA; FKKCRQY; -.
DR TreeFam; TF315900; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000010112; Expressed in heart and 7 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13188; FERM_C_PTPN14_PTPN21; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR014392; PTP_non-rcpt_14/21.
DR InterPro; IPR041782; PTPN14/21_FERM_C.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR45706:SF6; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 14; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PIRSF; PIRSF000934; Tyr-Ptase_nr14; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 21..309
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 920..1191
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1101..1182
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 498..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1132
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000934-1"
SQ SEQUENCE 1198 AA; 134820 MW; 8BE2567F8A8B41D2 CRC64;
MPFRLIMRRT RRYNVLSKNY FVTRIRLLDS NVIECTLSVE ATGQECLEAV AQRLELRETH
YFGLWFQGKT QAPPRRWVEL EKPLKKQLDK FGNEPLLFFG VMFYVPSVSR LEQEATRRYQ
YYLQVKKEVL DGRLHCTVEQ GIRLAGLAVQ ADFGDFTQFM SQDFLREYVL FPVNWPNGDE
VLEEWTQKVA EEHKSHCRMQ TAEAELLYIK EVEKLDGFGQ ESFPAKDNYT NDIFIGVSFI
GVFVKHRNGR SIMLHKWKDI GTIAHNKSAI TVEITSRDDT IIFHMEDMEM AKYIARLFTA
RHKFYKQNKI CAEPTHSPVP IRRRPTWTHR PSLPRPQSCN FQSMHSQYGE HYQDTQSSQD
SIFHDDPYYK SETSLDRCQV DFPFRNGTAP NGSMYSSPSL SSLNQSQTFV PASPMSSSLS
IPGSELMRPD YIPSHRHSAI IAPSYRPTPE YDAVMRQKRR MPPAHHDLHS QSLRSLNISN
ACAYRQPEAL VYSQPEMRER GPYHGLGPSP GPYGKQGGAA GSQGPCHSPC VNGGEGGGGG
VGSSISHTVS TPELANTKQQ GNNAGSSAAT ANMLRNHMSR PPPPYPSSSF RPATSTPDLA
SHRLRCMGGS SPELVTRMVQ LSVKTFQPDS SAVVHQSLQE VSEPLTAAAK HRSTLAKRHS
MEVISSMRGG GGGGLEGIVM KSINLALHRR NTLREHRSSK KSPASSASPA GAYQHQKTLS
NATMLIHSSE SEEEEEEEER PELDVQIPGL NEDISISAQL QAALAKLPNK PPPEYPGPPR
PVGNVQTRTH SHNHTQHHNH NPGPGGTLTR GDQGGVNGAV LGPSISEPDL TSVKERVRKE
PVKERPVSEL YSLQDSIVER EIAQRTLERQ KMSVDSMKRP LMIAALNGLY AARMPEDEGA
KASTDERCKT LELKLEEERV FTEYEQVPKK RADCVVTTAT LPENLERNRF RDVVPYEENR
VELVPNKENN TGYINASHIK VMIRGEEWHY IATQGPLAST CADFWQMVWE QGVNVIAMVT
AEEEGGRSKS HRYWPKLGSK HNSATHGKFK VTTKFRTDSG NYATTGLKVK HLLSGQERTV
WHLQYTDWPE QGCPEYVQGF LSYLEEIQSV RRHTNSMLDT SKSLNPPLVV HCSAGVGRTG
VVILTELMIS CLEHNEPVEV PTMLSELRQQ RVLMVQTISQ YTFVYQVLIQ FLKNSRLI
//
