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Database: UniProt
Entry: G3P757_GASAC
LinkDB: G3P757_GASAC
Original site: G3P757_GASAC 
ID   G3P757_GASAC            Unreviewed;      4964 AA.
AC   G3P757;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   28-MAR-2018, entry version 44.
DE   SubName: Full=Ryanodine receptor 2b (cardiac) {ECO:0000313|Ensembl:ENSGACP00000013431};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000013431, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000013431}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000013431}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   STRING; 69293.ENSGACP00000013431; -.
DR   Ensembl; ENSGACT00000013456; ENSGACP00000013431; ENSGACG00000010126.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G3P757; -.
DR   OMA; THEKWSL; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007635};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4294   4312       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4502   4521       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4570   4589       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4716   4741       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4764   4786       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4807   4825       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4845   4868       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      110    165       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      172    225       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      233    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    357       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      359    416       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      615    814       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1040   1229       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1352   1558       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4032   4067       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      479    499       {ECO:0000256|SAM:Coils}.
FT   COILED     3647   3667       {ECO:0000256|SAM:Coils}.
FT   COILED     3706   3733       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4964 AA;  557780 MW;  C08FB729261C2AEB CRC64;
     MADTGEGDDE FHFLRTGDEV VLQSTFTSLE EHVKICLGAE GFGSRLCRLE PTSNCKNVPP
     DLSVCGFVMA QCLSVRALQE MLAQSEHLAA EQVNFLKTQL ESQGEAGGSH RTLLYGQAVL
     FLHSHSGMYL SCLSSSHAST DKLAFDVGLQ EDKAGEACWW TVHPASRQRS EGEKVRVGDD
     LILVNVSSER YLHLSFGTAL DMKSLSESLI VNAAFQQTLW SVAPICSGSG VAQGYLRGDD
     TLRLLHSHSD ACLTIPSTQQ GEELQRIMHY ETGSVSSHAR SLWRLEILRV VWSGRHASWG
     QPFRLCHVTT GRYLGLTEEK GLYLVDRDKA DVDTTSFCFR SSKEKLDSCT KTHVDGMGVP
     EIKYGDSICY VQHVESGLWL TYQAVDAQST LMGWAQRKAI LHSEGHMDDG LSLSRCQREE
     SHTARLIRSA TLLFTCFIRK LDCLIQEGNL PSVSPPMEIV ACSLKDLIHY FLPLEGLSHE
     AKQNNMTALK NRQNMFQEEG VIDLVLDCID RLHQYSSGSH FAAHNDAQQE WVRILNNFYE
     LLAALIRGNR RSCAHFSASL DWLISRLDRL EASCGVLEVL HCVLVESPEA LNVIKEGHIL
     SIISFLDKHG CNHKVLEVLC SLCVCHGVAV RSNQNLICDN LLPDRDLLLQ TRLANQVTSM
     RPNIFLALGE ESAQHRRWYY ELVVDHVDSF LTSEPTHLRI GWARSEGYLP RPTGGEGWGG
     NGVGDDLCSY GFDGLHLWSG FVGRRVNSPF PHLLKDDDVV SCCLDLSALC ISFRVNGLPV
     QGMLENFSAD GLLHPVVSFS AGVKVRFLFG GKHGEFRFLP PPGFAPCSDA LLPGVELKVG
     PCQKYILACG EGKQELIGPL VPATPLTFTP TPVDISEVVL PPQLEDISEK MAENIHELWA
     MDRIDLGWTH GLVKDEVKKH NTCLVEFSKL SEQEKNQNLQ MSQDTLKRTL LALGFHIGLT
     DDHAEERIKY MRLSNKYEQP NGYTPAPLDL SQVFLSTAHK EVVNLLAEND HNVWARERIR
     QGWTYGAQQD VKVKRSPYLV PYSLLDERRR RAGRERVREA VCPLLAYGYS LEPLNQDRNT
     LSDTCLFAAE KYRVFRPDKS YSVTQGKWYF ELEIVTPGNI RVGWARPGCS PDKELGSDDQ
     AYVFDGFEAQ WHHRGVEPLG RPWHRGDVVG CLVDMAERTM IVALNGEVLF NGRGSELAAK
     DFHIADGLLP VVSVGVNQVG RLNLGHRVGS LRYFTVCGQQ EGYRPFAVNM ARDPALWMSW
     KQPQFTSIVP DDPNLQVTRI SGSKDSLSSL RVSQRLFAHH GGGSELGFYR LSMFVECAAV
     LSSPAAAVLP VASSSLSQGR KEPEEVDSDF EVLMKSAHSF AGSRDELNHK DHSHDKTSRL
     KQRFMLKRTK PELISSNSSA RLLEDVVVDK DQCDHLLQSS RYNFSVRVLP GQEPFALWAG
     WVTSDFHQHD MTFDTDSVLT VTVTLGDDSG KVQESVKRCN CYMVCAGDAT GLSQSRRSTG
     LEIGCLIDTA TGMLTFTSSG MEMATFYQVE AGTKLFPAVF VKPTTSNMFQ FELGHKKNVM
     PLSAGLLRRQ RRNATPQCPP RLQVQHLTPV SWIRVPDRAL EVMVDRPDER RGWRVQCHEP
     LQVMTLHVPD ENRCVNISEL SEHGDLLNFH HHTLLLYCSL CALGNSRVCH ALCSHVDQSQ
     FVYAIKNPHL PSLLRSAFFQ LLIQVHLSSH TTACHMMNHE YIVPMTDQTR KITLYPGPAD
     GVNGVKGQPP EAVSCAGLST SLKPQMHFSS PCFVRSDGME GDGAGDVACT DSPDIPLDML
     KDLTVEMLTA GVWAVGQGVR DPIGGSIELL LVPLIKLFYV LLVLGVFGDE DLGKVLRLIE
     PGVFSIDGGT TEKEEEEGAS DDEKEYDGCN KKEGYPLKRG LLQMKLPEAV KLELCHLLSY
     LCDRQVRHRV EALVAFSDDF VGRLQENQRF RYNQVMRALN MSAALTARKT KEFRSPTQEQ
     INMLLSFTGG KQQENCPCPV EIQQLLKDFH RLLSTHCGVE LDGDSEDEED AEMSLKDRLF
     SRVARVVGLM KTPMEVERSR PHSAKSLKAL ISETMVRWAQ EAEMEDPELV RAVFSLLHRQ
     YQGLGGQMAE HLSRAYTISQ AAVEDTMALL SSLSQIRSLL SVRMGKEEEW LMIRRLGDIM
     NNKIFYQHPN LMRALGIHET VMEVMVNVLG EGESKEITFP KMVASCCRFL CYFCRISRHN
     QGALFDHLSY LLENSSVGLA SPAMRGATPL DVAAASVMDN NELALALREP DLEKVVLYLA
     GCGLESCPML VAKGYPDLGW NPVEGERYLD FLRFAVFCNG ESVEENAYVV LRLLIRRPEC
     FGPALRGDEG NGLLAAMEEA IRIAEDPSMD GPRSTSQPNR TLSVQDNDDD LIHMGHAIMT
     FYSALIDMLG RCAPEMHLIQ GGKGEAIRIR AILRSLVPIQ DLQGVISISF QIPSVSEDGL
     VVEPDLSTVF CPDHKAAVVL FLDRVYGIEH QNFLLHLLEV GFLPDLRAAV SLDTAELGST
     DMALALNRYL CTSVLPLLTK CSALFCPLED HALLVDSLIQ AIYNLSRALS LTKAQRDTIE
     ECLLAVCSKL QPAMMQPLLR RLVFDVPHLT ANSKMPLKLL SAHYEQRWKY YSLAGGPADH
     GSASEEELHL SRKLFWGVFN ALPKKHYEPQ LFTLSVQCLA AVATALPPDH MDSSCVSRTE
     RKASMDTEGH FDPQPVDTAN VSVPEGLEFV VNKCAEHTHE KWSLDKFANG WVHGEQLCEK
     TKVHPLLKPY RALAEKEKDA YRWAIKETLK TMLAFGWTIE RAKEGDAFGT FTCTQRVSQA
     GQLSFEGAST FSPKPMDMSS ITLSWDQCAM AELLAENYHN AWAKRKKLDV LTAGGGGHSM
     LAPYDTLSAK EKTKLRERAK DILKFLRLNG YTVWRDRRTA EMDFPAIANC FGYALLQRLL
     SHTEDTQGNM LELEVIQDRG QMSKREKASH QQAMFFFKQV VLPLLEQFVK SHCQYFLSTS
     LCSRSYASKK EKEMIASLIC KLAALVRHRI SLFGNEVSSV ASCLHVLSHA LDARTLMNSA
     PESIHVSLHS FFEAAATDLE MTVENLTLVS SPQSRNQSPR GAAKVLSFTT SVLLPTLTSL
     FQHLGKQNYG VDILVGKIQL SCYRILNSLL SLGTSSSFYV EGQRPAAGAC LAALAGTFPV
     CFLEPSLNQS NPYSIYNTMT APQREDLGLP DAVEDMCPLL PSLEQALGEV EKFAGAGAAA
     HQAHYMQVTE VTLPMLCSYV SRWWHGGPGG QPASAICSAV TPQHASDLLG HILRIIHNHV
     GASQGDWMKR LAVFSQPITC KAGSELLKSH FLPLMEKLRK RAKCVLLEEE QMKSGGCDTS
     EAELQIQEKF TVLVQDLYAF YPLLIPFVDS NRASWLKDVN PDAEQLFGMV AEVFTFWAKS
     HNFKWEEQNF VVQNEINNLA FLVNSDRMSK LIDAQFDHEQ RRMKRKGDRY STHTSLVVAS
     MKRLLPVGLG LCFPSEHGLI TFAKSGFAQK NSRDEIREHV FDRLINLHNQ ASDGSRQESI
     HAEHLSQLRA VSDAQKTVNS ILEIAQVLHY LDQVRKTFPR LLRVQVEHPQ RSQKPAWHKV
     LSKQRKRAVV ACLRMAPLYN LPRHRAVNLF LQGYNKSWIS AEDHNFEEKL VEDLAGDREE
     KKNVEERAKP IDPLLQLITH FSRSAQVESK PENDGLYKSY ATIMAKSCHR DDNDDEEQEV
     ESFEEKEMEK QKLLYQQARL HHRGASEMVL QTISASKGAI DSMIAPTLKL GIAVLNGGNA
     AVQQRMLDYL REKQDVGFFQ SMAGLMRSCS VLDLNAFERQ NKAEGLGMAT DDSSAGKVMP
     DKDLTCDLFR YLQLLCEGHN SDFQNYLRTQ TGNTTTVNII ITTVDYLLRV QESISDFYWY
     YSGKDVIDVH GQRNFSKAIE VAKQVFNTLT EYTQGPCSGN QQSLAHSRLW DAVVGFLHVF
     AHMQMKLSQD SKQIELLKEL MDLQKDMVVF LLSMLEGTVV NGTIGKQMVD MLVESSGNVK
     KILRFFDIFL KLKDLTSSDA FKEYDPDHKG CISRKDFQKA MENCKRFSQA EIPFLLSCMK
     TSDSEIVDYE VFVDRFHEPA KDIGFSIAVL LTNLSEHMPN DSRLEAFLEL AQCVLTYFQP
     FLGRIEILGS GKRIERVYFE ISESSRTQWE KPQVKESKRQ FIFDVITQGG EKEKMEMFVN
     FCEDTIFEMQ LAAQISGSDA GERHADEGEE QSEDEAEGNK GTFLLHSWLL LLSSLFSFKN
     LKALMKMTLK DILVSAALFL RFILTAQLRC VRVVTGSISN ALYVAFVSGG LIEGAKRMRM
     SDLLDGILEP TLDEVTKVPT GVDRLRRYSA SFTSQRELWE AGHVAAVTSP REMDVLSDIF
     GFKVKKEGGQ YRLITPDLTA SLTDLFNPTS KTITATDFSE KHRGTTHSAA DEKEDHETIP
     EVKDGKGNET VTKTEKDSRC KVERCNKSKE PESQHSAFWE IIISHNKSLL NYFARKFYHM
     RLLALFVAFA VNFILLFYKV ASLPTSQEEE EVLPSVTSDG LNSSANDNNE GSDYFVLEES
     SGYMEPSLRF LAVAHTIISF CCIIGYYCLK VPLVIFKREK EVARKLEFDG LYVIEQPPEE
     DIKGQWDRLV INTPSFPSNY WDKFVKKKVM DKYRDFYGCE KISELLGLDQ AGLDFSSERK
     ERRRLQRQAA WSTLFNSIDV KYQVWKLGVV FTDNSFLYLA WYMAMSVLGH YNNFFFAAHL
     LDIAMGFKTL RTILSSVTHN GKQLALTVGL LAVVVYLYTV VAFNFFRKFY NKSDDEDARD
     MKCNDMLTCY MFHMYVGVRA GGGIGDEIED PAGDAFEVER IVFDITFFFF VIVILLAIIQ
     GLIIDAFGEL RDQQEQVKED METKCFVCGI GSEYFDSVPH GFETHTLQEH NLANYLFFLM
     YLINKDETEH TGQESYVWKM YQERCWEFFP VGDCFRKQYE DQLG
//
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