ID G3P781_GASAC Unreviewed; 615 AA.
AC G3P781;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=procollagen galactosyltransferase {ECO:0000256|ARBA:ARBA00038926};
DE EC=2.4.1.50 {ECO:0000256|ARBA:ARBA00038926};
GN Name=COLGALT1 {ECO:0000313|Ensembl:ENSGACP00000013455.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000013455.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000013455.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000013455.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose =
CC (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) +
CC UDP; Xref=Rhea:RHEA:12637, Rhea:RHEA-COMP:12752, Rhea:RHEA-
CC COMP:12753, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:66914,
CC ChEBI:CHEBI:133442, ChEBI:CHEBI:133443; EC=2.4.1.50;
CC Evidence={ECO:0000256|ARBA:ARBA00036299};
CC -!- SIMILARITY: Belongs to the glycosyltransferase 25 family.
CC {ECO:0000256|ARBA:ARBA00006721}.
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DR AlphaFoldDB; G3P781; -.
DR STRING; 69293.ENSGACP00000013455; -.
DR Ensembl; ENSGACT00000013480.1; ENSGACP00000013455.1; ENSGACG00000010165.1.
DR eggNOG; KOG4179; Eukaryota.
DR GeneTree; ENSGT01030000234558; -.
DR InParanoid; G3P781; -.
DR OMA; VVWNNEQ; -.
DR TreeFam; TF313826; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000010165; Expressed in zone of skin and 12 other cell types or tissues.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd06532; Glyco_transf_25; 1.
DR InterPro; IPR002654; Glyco_trans_25.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR10730:SF28; PROCOLLAGEN GALACTOSYLTRANSFERASE 1; 1.
DR PANTHER; PTHR10730; PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER; 1.
DR Pfam; PF01755; Glyco_transf_25; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..615
FT /note="procollagen galactosyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003449288"
FT REGION 580..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 615 AA; 71361 MW; 4C44BD1ED59723EC CRC64;
LAAAMAGLAR LPAALLALLL SGCCAPARAY FAEERWSPES PLLAPRVFLA LVCRNAEHSL
PYFLGTVERL NYPKERMALW VATDHNQDNT TAILRDWLVK MQSLYHNVEW RPKEEPQHYR
NEEGPKQWTD LRYEHVMKLR QVAMDSAREM WADYFMLADC DNLLTNPDVL WKLMQENKTI
VAPMLESRAA YSNFWCGMTS QGYYKRTPAY IPIRKQIRKG CFAVPMVHST FLIDLRKEAS
RQLAFHPPHP EYSWAFDDII VFAFSARMAD VQMFVCNKET YGYFPVPLRS HNTLQDEADS
FLHSLLDVNV RNPPVMPSKY IRVPRKQPDK LGFDEVFMIN LQRRTDRRER MMRALYHQGI
ECKVIAAVDG KATNISEIHA MGIHMLPGYN DPYHGRPLTK GELGCFLSHY NVWKEVAERR
LHTSLVIEDD LRFEIFFKRR LMNLMREVED EGLDWDLIYI GRKRMQVDHP EKAVPNIHSL
VEADYSYWTL GYMISLQGAE KLLKAEPLKR VLPVDEFLPI MYNKHPVPAY MEQFETRDLK
AFSAEPLLVY PTHYTGDQGY ISDTETSTVW DNDKVRTDWD RARSGKTGEQ AEISTEAQNS
DVLQSALDST ARDEL
//
