ID G3P920_GASAC Unreviewed; 2652 AA.
AC G3P920;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Dynein cytoplasmic 1 heavy chain 1 {ECO:0000313|Ensembl:ENSGACP00000014094.2};
GN Name=DYNC1H1 {ECO:0000313|Ensembl:ENSGACP00000014094.2};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000014094.2, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000014094.2, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000014094.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 69293.ENSGACP00000014094; -.
DR Ensembl; ENSGACT00000014119.2; ENSGACP00000014094.2; ENSGACG00000010634.2.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000156103; -.
DR InParanoid; G3P920; -.
DR OMA; ISHFYQF; -.
DR TreeFam; TF101165; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000010634; Expressed in telencephalon and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.920.60; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 224..529
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 594..744
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 936..1102
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1212..1260
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1409..1506
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2652 AA; 303105 MW; 4E3949D3A7110D92 CRC64;
SGVPVTTELL NKQVKVSPDM AIFITMNPGY AGRSNLPDNL KKLFRSLAMT KPDRQLIAQV
MLYSQGFRTA EILAKKIVPF FKLCDEQLSS QSHYDFGLRA LKSVLISAGN VKRERIQKIK
REKLERGEVV DENEIAENLP EQEILIQSVC ETMVPKLVAE DIPLLFSLLS DVFPGVQYMR
GEMTALREEL KKVCAEMYLT YGDGDDVGSM WVEKVLQLFQ ITQINHGLMM VGPSGSGKSM
AWRVLLKALE RLEGVEGIAH IIDPKAISKD HLYGTLDPNT REWTDGLFTH ILRKIIDNVR
GELQKRQWII FDGDVDPEWV ENLNSVLDDN KLLTLPNGER LSLPPNVRVM FEVQNLKYAT
LATVSRCGMV WFSEDVLSTD MIFNHFLARI RSIPLDEGED EALRQRKGTE DEDETASPML
QIQRDSAAIL QPYFTSTGLV IKALEHASKM EHIMDFTRLR CLSSLFSMLH QACRNVALYN
NNHPDFPMPI EQLERYMQRY LIYAVLWSFS GDGRLKMRAE LGEYIRRITT VPLPSAPNVP
IIDYEVCISG EWQSWQGKVP QIEVETHKVA SPDVVVPTLD TVRHEALLYT WLAEHKPLVL
CGPPGSGKTM TLFSALRALP DMEVVGLNFS SATTPELLLK TFDHYCEYRR TPNGVVLSPV
QLGKWLVLFC DEINLPDMDK YGTQRVISFI RQMVEHGGFY RTSDQTWVKL ERIQFVGACN
PPTDPGRKPL THRFLRHVPV VYVDYPGPAS LTQIYGTFNR AMLRLIPSLR TYAEPLTAAM
VEFYTMSQER FTQDTQPHYI YSPREMTRWV RGIFEALRPL ETLPVEGLIR IWAHEALRLF
QDRLVDDEER RWTDDNIDVV ALKHFPNIEK EKALNRPILY SNWLSKDYIP VEQEELRDYV
KARLKVFYEE ELDVPLVLFN EVLDHVLRID RIFRQPQGHL LLIGVSGAGK TTLSRFVAWM
NGLSVYQIKV HRKYTGEDFD EDLRTVLRRS GCKNEKIAFI MDESNVLDSG FLERMNTLLA
NGEVPGLFEG DEYATLMTQC KEGAQKEGLM LDTHEELYKW FTSQVIRNLH VVFTMNPSSE
GLKDRAATSP ALFNRCVLNW FGDWSTEALY QVGKEFTSKM DLEKPNYKVP DYMPAVYDKL
PQTPSHREAI VNGCVFVHQT LHQANNRLAK RGGHTMAITP RHYLDFINQY ANLFNEKRSE
LEEQQMHLNV GLRKIKETVD QVEELRRDLR IKSQELEAKN AAANDKLKKM VKDQQEAEKK
KVMSQEIQEA VYKQQEVIKD KQLSVKEDLD QVEPAVIEAQ NAVKSIKKQH LVEVRSMANP
PAAVKLALES ICLLLGESTT DWKQIRSIIM RENFIPTIVN FEAEEISDSI REKMKKNYMS
NPSYNYDQVN RASLACGPMV KWAIAQLNYA DMLKRVEPLR NELQKLEDDA TDNKTKAESV
EQMIRDLEAS IARYKEEYAV LISEAQAIKA DLAAVEAKVN RSTALLKSLS AERDRWEKTS
ETFKNQMSTI AGDCLLSAAF ISYAGYFEQQ MRQNLFTTWS HHLQQANIQF RTDIARTEYL
SNADERLRWQ ANSLPADDLC TENAIMLKRF NRYPLIIDPS GQATEFIMNE YKERKITRTS
FLDDAFRKNL ESALRFGNPL LVQDVESYDP ILNPVLNREV RRTGGRVLIT LGDQDIDLSP
SFVIFLSTRD PTVEFPPDLC SRVTFVNFTV TRSSLQSQCL NEVLKAERPD VDEKRSDLLK
LQGEFQLRLR QLEKSLLQAL NEVKGRILDD DTIITTLENL KKEAAEVTRK VEETDIVMAE
VEAVSQQYLS LSSACSSIYF TMESLNQMHF LYQYSLHFFL DTYHTVLYEN PNLKGITDHT
QRLDVITKDL FQVVFNRTAR GMLHHDHITF AMLLAKISIK GITSEPSYDV EFQHFLRGKE
IVLTGMTLPK VNGLTTEQSE AMVRLSRLPA FSDLVDKVQA DEQFFMWIES NTPDLAVPYL
WSEEKQSTPI GQAVHQLLLI QAFRPDRLLA MSHIFVSKVL GETFMNIIEQ PLDLANIVDS
EVKPSTPVLM CSVPGYDASG LVRDLAAEEN KPITSISIGS AEGFNKADRD INTAVKSGRW
VMLENVHLAP GWLMQLEKKL HSMQPHASFR LFLTMEINPK VPVNLLRAGR IFVFEPPPGV
KANMLRTFSS IPVARMCKAP NERARLYFLL AWFHAVIQER LRYAPLGWSK KYEFGESDLR
SACDTIDTWL DDTAKGRQNI APDKIPWAAL KTLMAQSIYG GRIDNEFDQR LLNTFMDRIF
TKRSFDSEFK LALKVDGHKD IKMPDGIRRE EFMHWVEMLP DTQTPSWLGL PSNAEKVLLT
TQGTDMMGKM LKMQTLEDED DLAYETEIKE RTSSASDAQP AWMRTLHTTA CNWLQLMPQT
VNPLKRTVEN IKDPLFRFFE REVKMGGKML QEVRQDLADV VQVCEGKKKQ TNDLRTLISD
LVKGILPRGW CRYTVPAAMT VIQWVADFSE RIKQLQQISQ GAASGGAKEL KNIHVCLGSL
FVPEAYITAT RQYVAQANSW SLEELCLEVN VTTAQGAALD ACSFGIKGLT LQGAVCGNNK
LSLSTSISTE LPLTQLRWIK QSNAESRHMQ VTLPVYLNFT RSDLIFTVDF DIATKEDPHS
FYERGVAVLC TE
//
